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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Syst. Neurosci. | doi: 10.3389/fnsys.2019.00061

The cortico-basal ganglia-cerebellar network: past, present and future perspectives

 Demetrio Milardi1, 2,  Angelo Quartarone1*, Alessia Bramanti2, Giuseppe Anastasi1, Salvatore Bertino1, Gianpaolo A. Basile1, Piero Buonasera2, Giorgia Pilone2, Giuseppe Celeste3, Giuseppina Rizzo1, Daniele Bruschetta1 and  Alberto Cacciola1*
  • 1University of Messina, Italy
  • 2Centro Neurolesi Bonino Pulejo (IRCCS), Italy
  • 3I.S.A.S.I. E. Caianello, National Research Council, Italy

Much of our present understanding of the function and operation of the basal ganglia rests on models of anatomical connectivity derived from tract tracing approaches in rodents and primates. However, the last years have been characterized by promising step forwards in the in vivo investigation and comprehension of brain connectivity in humans. The aim of this review is to revise the current knowledge on basal ganglia circuits, highlighting similarities and differences across species, in order to widen the current perspective on the intricate model of the basal ganglia system. This will allow us to explore the implications of additional direct pathways running from cortex to basal ganglia and between basal ganglia and cerebellum recently described in animals and humans.

Keywords: Cerebellum, connectomics, Globus pallidum, Substantia Nigra, tractography

Received: 23 Apr 2019; Accepted: 08 Oct 2019.

Copyright: © 2019 Milardi, Quartarone, Bramanti, Anastasi, Bertino, Basile, Buonasera, Pilone, Celeste, Rizzo, Bruschetta and Cacciola. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Angelo Quartarone, University of Messina, Messina, 98122, Sicilia, Italy,
Dr. Alberto Cacciola, University of Messina, Messina, 98122, Sicilia, Italy,