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ORIGINAL RESEARCH article

Front. Ophthalmol.
Sec. Glaucoma
Volume 4 - 2024 | doi: 10.3389/fopht.2024.1418566
This article is part of the Research Topic Effect Modifiers and Risk Factors of Glaucoma Diagnosis and Progression View all articles

Relationship between Anterior Segment Biometry and Primary Angle-Closure Glaucoma in Hubei Region: A Retrospective Case-Control Study

Provisionally accepted
Shan Wang Shan Wang 1Han Zhang Han Zhang 1,2Wanju Yang Wanju Yang 1*Ying Zhang Ying Zhang 1Hui Qin Hui Qin 1Man Wang Man Wang 1Xinlan Lei Xinlan Lei 1Kuiliang Yang Kuiliang Yang 1,2Hong Zhang Hong Zhang 1Yiqiao Xing Yiqiao Xing 1*
  • 1 Aier Eye Hospital of Wuhan University, Wuhan, Hebei Province, China
  • 2 Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the pathogenesis of Primary Angle-Closure Glaucoma (PACG) and its relationship with the anatomical structure of the anterior segment by obtaining biometric parameters using the IOL-Master 700.A retrospective case-control study was conducted. Clinical data from 39 PACG patients and 40 normal controls treated at the Aier Eye Hospital affiliated with Wuhan University from January to December 2022 were collected. Anterior chamber depth (AC), white-to-white (WTW), lens thickness (LT), central corneal thickness (CCT), axial length (AL), corneal curvature (K1), corneal curvature (K2), and lens position (LP) were measured using the IOL-Master 700 to analyze the characteristics and differences in the anterior segment structure of both groups. Statistical methods included independent sample t-tests and logistic regression analysis.Results: Significant differences were found in the anterior segment biometric parameters between PACG patients and normal controls (p<.05). Anterior Chamber depth, White-to-White, Lens Thickness, Central Corneal Thickness, Axial Length, and K2 were all related to the occurrence of PACG (p<.05). The occurrence of PACG was negatively correlated with ACD, CCT, and AL (OR=.12~.64, p<.05), and positively correlated with LT.Compared to the normal control group, PACG patients in the Hubei region have a smaller anterior segment space, narrower angles, thicker lens, thinner cornea, shorter axial length, flatter cornea, and more anteriorly positioned lens.

    Keywords: Primary angle-closure glaucoma, IOL-Master 700, Anterior chamber depth, White-to-white, Lens thickness, central corneal thickness, Axial length

    Received: 16 Apr 2024; Accepted: 21 May 2024.

    Copyright: © 2024 Wang, Zhang, Yang, Zhang, Qin, Wang, Lei, Yang, Zhang and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wanju Yang, Aier Eye Hospital of Wuhan University, Wuhan, Hebei Province, China
    Yiqiao Xing, Aier Eye Hospital of Wuhan University, Wuhan, Hebei Province, China

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