REVIEW article
Front. Drug Deliv.
Sec. Technological and Methodological Advances in Drug Delivery
Volume 5 - 2025 | doi: 10.3389/fddev.2025.1633141
Research Progress on Exosomes as Drug Delivery Vehicles
Provisionally accepted
- Guilin Medical University, Guilin, China
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Our goal is to contribute theoretical basis for exosomes as nano-drug delivery systems. The mechanism, advantages and disadvantages of exosomes-based nano-drug delivery technology are reviewed. Quantitative comparison was made with other nano-drug delivery systems. Nano-drug delivery system based on exosomes has become a general choice for targeted therapy of many diseases.【Abstract】Exosome is a nano-scale (30 ~150 nm) extracellular vesicle secreted by cells, which contains a bilayer lipid structure similar to the cell membrane. Because of its unique structure and origin, it has the functions of anti-inflammation, anti-apoptosis, promoting cell formation and immune regulation. Therefore, exosome has significant innate advantages as a drug delivery system. By describing the structure, function, drug-loading mechanism and application of exosome in diseases, and combining the advantages and limitations of exosome as a drug delivery system, this paper comprehensively and systematically summarizes the latest progress of exosome as a drug carrier, with a view to providing theoretical basis for subsequent clinical studies. This paper introduces new concepts and methods for the treatment of various pathologies.
Keywords: drug delivery system, targeted delivery, nanocarriers, Exosomes, clinical application
Received: 22 May 2025; Accepted: 08 Jul 2025.
Copyright: © 2025 Lin, Dong, He, Pan, Wang, Tang, Huang and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: XueKun Xing, Guilin Medical University, Guilin, China
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