REVIEW article
Front. Epigenet. Epigenom.
Sec. Chromatin Epigenomics
This article is part of the Research TopicTranslational Epigenetics in Medicine: From Biomarker Discovery to Clinical ApplicationView all 3 articles
Histones deacetylases in the epidermis: structure, functions and therapeutic implications
Provisionally accepted
- 1Biologie Tissulaire et Ingenierie Therapeutique, Lyon, France
- 2Universite Claude Bernard Lyon 1, Villeurbanne, France
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ABSTRACT Histone deacetylases (HDACs) are key epigenetic regulators that catalyze the removal of acetyl groups from histones and non-histone proteins, thereby modulating chromatin accessibility and gene expression. The HDAC family is composed of 11 HDACs and 7 sirtuins that are all located within the epidermis. These enzymes are involved in essential cellular processes such as proliferation, differentiation, the regulation of immune function and wound healing, thus playing a central role in maintaining tissue homeostasis. This review aims to explore the mechanistic contributions of HDACs to epidermis physiology and investigate their involvement in the development of diseases such as psoriasis, atopic dermatitis and cancers. It also highlights the therapeutic potential of HDAC inhibitors, which are already used in oncology but whose application in dermatology is still emerging.
Keywords: HDACs, Epidermis, Skin, epigenetics, Melanoma, Psoriasis
Received: 26 Sep 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Nguyen Van and Lamartine. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jérôme Lamartine, jerome.lamartine@univ-lyon1.fr
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