REVIEW article
Oncol. Rev.
Sec. Oncology Reviews: Reviews
This article is part of the Research TopicRNA Methylation and Demethylation in Tumorigenesis and as Therapeutic TargetsView all 8 articles
Epigenetic regulation of RNA methylations in gastric cancer
Provisionally accepted
- The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
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Gastric cancer (GC) remains a major global health challenge due to its high incidence and mortality. Emerging evidence underscores the critical role of RNA methylation, a key layer of epigenetic regulation, in GC pathogenesis. This review synthesizes current knowledge on various RNA modifications, including m6A, m5C, m1A, and m7G, in GC. We critically evaluate the functions of their regulatory proteins (writers, erasers, readers) in modulating oncogenic signaling, metastasis, and tumor immunity. Among these, m6A and m5C modifications currently present the most compelling evidence, demonstrating significant correlations with patient prognosis and therapy resistance. Furthermore, we explore the translational potential of targeting the RNA methylation machinery, discussing both promising avenues and existing challenges in drug development. This comprehensive analysis aims to provide deeper mechanistic insights and highlight novel therapeutic opportunities for GC.
Keywords: gastric cancer, epigenetics, RNA methylation, M6A, m5C, m1A, m7G
Received: 28 Mar 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Liu, Liu, Zhang, Li, Qu, Li and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Penghui Li, lph0819@163.com
Xinjun Hu, hxj5129@163.com
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