REVIEW article
Oncol. Rev.
Sec. Oncology Reviews: Reviews
Volume 19 - 2025 | doi: 10.3389/or.2025.1637372
This article is part of the Research TopicRNA Methylation and Demethylation in Tumorigenesis and as Therapeutic TargetsView all 6 articles
METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value
Provisionally accepted
- 1Shandong Second Medical University, Weifang, China
- 2Liaocheng People's Hospital, Liaocheng, China
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Methyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in various cancers, focusing on the mechanisms underlying tumorigenesis, progression, and metastasis. Furthermore, the therapeutic value and targeting strategies for METTL1 are also discussed to provide the foundation for further development of METTL1-targeted therapies. The article integrates recent research findings to highlight significant discoveries regarding METTL1, emphasizing its potential as a therapeutic target in cancer treatment.
Keywords: METTL1, Cancer, RNA methylation, Therapeutic target, tumor mechanism
Received: 29 May 2025; Accepted: 15 Jul 2025.
Copyright: © 2025 Zhang, Chen, Li, Zhou and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qingcui Song, Liaocheng People's Hospital, Liaocheng, China
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