CASE REPORT article
Front. Radiol.
Sec. Neuroradiology
This article is part of the Research TopicAdvances in Medical Imaging and Artificial Intelligence: Diagnosis and TreatmentView all 6 articles
Fibrolipomatous Hamartoma of the Sciatic Nerve: An Atypical Case Report
Provisionally accepted
- 1Radiology and Medical Imaging Department,, King Saud Medical City, Riyadh, Saudi Arabia
- 2Radiology and Medical Imaging, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia
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Fibrolipomatous hamartoma is a rare benign overgrowth of tissue consisting of intermixed adipose and fibrous connective tissue within the epineurium. However, involvement of the sciatic nerve is exceptionally rare. We present the case of a 46-year-old female who exhibited a progressively enlarging mass in her right posterior thigh, accompanied by sciatica and gluteal pain. Clinical assessment and MRI revealed a large lesion along the sciatic nerve with characteristic features of fibrolipomatous hamartoma. MRI findings demonstrated characteristic features, including isointense (to fat) on T1-weighted images and hyperintense with fat suppression on short tau inversion recovery sequences, indicating a sciatic nerve fibrolipomatous hamartoma. The diagnosis was histopathologically confirmed following surgical excision. This case highlights the critical role of identifying specific MRI features of this rare entity to avoid unnecessary invasive interventional procedures. An accurate MRI-based diagnosis can significantly impact clinical decisions and improve patient care.
Keywords: Fibrolipomatous1, Hamartoma2, nerve3, rare4, sciatic5, MRI6, surgery7
Received: 10 Jul 2025; Accepted: 30 Oct 2025.
Copyright: © 2025 EL Ghamdi, Elawad, Karem and Alsaadi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mohammed J. Alsaadi, m.alsaadi@psau.edu.sa
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