ORIGINAL RESEARCH article
Front. Reprod. Health
Sec. Assisted Reproduction
Volume 7 - 2025 | doi: 10.3389/frph.2025.1504082
This article is part of the Research TopicArtificial Intelligence in Assisted Reproductive TreatmentsView all 5 articles
Retrospective analysis of clinical pregnancy outcomes in patients with chromosome 9 inversion
Provisionally accepted
- 1Northwest Women’s and Children’s Hospital, Xian, China
- 2reproductive, Northwest Women’s and Children’s Hospital, Xian, China
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Purpose To investigate whether Preimplantation genetic testing for aneuploidy (PGT-A) improves clinical outcomes among couples with pericentric inversion of chromosome 9. Methods This retrospective analysis included data from 340 couples with inversion 9 from 2018 to 2022. Clinical outcomes were compared between the PGT-A group (n=31) and the conventional in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) group (n=309).Compared with other autosomes, chromosome 9 did not have a greater frequency of aberrations in embryos (0.062% vs. 0.074%, p>0.05). The cumulative live birth rate (CLBR) per ovarian stimulation cycle and cancellation rate were comparable between the PGT-A group and the IVF/ICSI group (OR 1.630, 95% CI 0.588-4.516; OR 0.271, 0.057-1.281, respectively). However, the PGT group presented significantly fewer embryo transfers (ETs) than the control group did (1.06 vs. 1.31, OR 0.628, 95% CI 0.468-0.843). The LBRs per embryo transfer were similar between the PGT group and the IVF/ICSI group at the first single blastocyst transfer cycle (OR 2.298, 95% CI 0.550-9.595), as were the clinical pregnancy rates (OR 1.036, 95% CI 0.223-4.820) and the pregnancy loss rates (OR 0.161, 95% CI 0.017-1.571). Conclusion(s): Clinical outcomes among inversion 9 carriers were similar between the PGT and IVF/ICSI groups. However, PGT can decrease the number of ETs required to reach a live birth for inversion 9 carriers. Based on the oocyte utilization rates, PGT is not recommended for inversion 9 carriers.
Keywords: Preimplantation genetic testing (PGT), Pericentric inversion of chromosome 9, Recurrent pregnancy loss, chromosome 9 carriers, Chromosomal rearrangements
Received: 30 Sep 2024; Accepted: 03 Sep 2025.
Copyright: © 2025 Jia, Xue and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xia Xue, Northwest Women’s and Children’s Hospital, Xian, China
Wenhao Shi, reproductive, Northwest Women’s and Children’s Hospital, Xian, China
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