REVIEW article
Front. Reprod. Health
Sec. Gynecology
Volume 7 - 2025 | doi: 10.3389/frph.2025.1550814
This article is part of the Research TopicInnovations and Early-Career Research in Gynecology 2024-2025View all articles
Risk factors and Countermeasures for abnormal uterine bleeding during dienogest therapy for adenomyosis: a review
Provisionally accepted
- Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
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Adenomyosis, an estrogen-dependent disorder, requires long-term therapy as current treatments (GnRH agonists, danazol, etc.) show symptom recurrence post-discontinuation. Dienogest (DNG), a selective progesterone receptor agonist, effectively reduces adenomyosis-related pain but causes abnormal uterine bleeding (AUB) in some patients, likely due to pseudodecidual breakthrough bleeding, significantly impacting treatment compliance. This review examines risk factors for DNG-associated AUB and advances in management strategies to improve patient adherence during prolonged therapy
Keywords: Adenomyosis, Dienogest, Abnormal uterine bleeding, Risk factors, countermeasures
Received: 24 Dec 2024; Accepted: 05 Jun 2025.
Copyright: © 2025 Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shiyu Zhang, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
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