CASE REPORT article

Front. Reprod. Health

Sec. Assisted Reproduction

Volume 7 - 2025 | doi: 10.3389/frph.2025.1585308

First live birth after in vitro fertilization in a woman with Alström Syndrome: a case report

Provisionally accepted
Andrea Roberto CarossoAndrea Roberto Carosso1Marco CarossoMarco Carosso1,2*Alberto RevelliAlberto Revelli3Stefano CanosaStefano Canosa4Luca MarozioLuca Marozio1Gianluca GennarelliGianluca Gennarelli1Pietro MaffeiPietro Maffei5Serena DitarantoSerena Ditaranto6Chiara BenedettoChiara Benedetto1
  • 1Division of Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin (Università degli Studi di Torino), Turin, Piedmont, Italy
  • 2University of Turin, Turin, Italy
  • 3Division of Gynecology and Obstetrics 2, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Piedmont, Italy
  • 4IVIRMA, Global Research Alliance, LIVET, 10126, Turin, Piedmont, Italy
  • 5Department of Medicine, University of Padua, Padua, Veneto, Italy
  • 6Department of Anesthesiology and Intensive Care A.O.U. Città Della Salute E Della Scienza Di Torino, Turin, Piedmont, Italy

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Alström syndrome (AS) is an extremely rare, autosomal recessive genetic disorder. Fertility implications are particularly relevant for women affected by AS and no cases of patients achieving pregnancy and live birth with In Vitro Fertilization (IVF) have been previously described. This report describes the first worldwide live birth after IVF in a woman affected by AS.This case report describes the IVF procedure and pregnancy management of an infertile woman suffering from AS.After two ICSI, combined with Preimplantation Genetic Testing for aneuploidies (PGT-A), an euploid blastocyst was transferred, obtaining a clinical pregnancy. Gestation was complicated by gestational diabetes mellitus and chronic hypertension, which were well controlled by specific treatments. At 38 weeks of gestation, a healthy child of 3110 gr was born.The successful outcome of this rare case suggests that IVF is feasible in case of women with AS, but a multidisciplinary, continuous follow-up aimed at controlling comorbidity-linked complications is needed.

Keywords: Alstrom Syndrome, In vitro fertiization, Pregnancy, ICSI, Preimplanation genetic diagnosis

Received: 28 Feb 2025; Accepted: 24 Jun 2025.

Copyright: © 2025 Carosso, Carosso, Revelli, Canosa, Marozio, Gennarelli, Maffei, Ditaranto and Benedetto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Marco Carosso, University of Turin, Turin, Italy

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