CASE REPORT article
Front. Reprod. Health
Sec. Assisted Reproduction
Volume 7 - 2025 | doi: 10.3389/frph.2025.1627160
Successful live birth of a healthy infant by preimplantation genetic testing for aneuploidy in a couple with recurrent spontaneous abortion: A case report
Provisionally accepted
- 1Sun Yat-sen Memorial Hospital, Guangzhou, China
- 2Xinjiang Medical University, Urumqi, China
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Recurrent spontaneous abortion (RSA), characterized by the occurrence of three or more pregnancy losses prior to the 28th week of gestation, stands as a formidable challenge in the realm of assisted reproductive medicine, presenting significant difficulties in both clinical diagnosis and treatment. In recent years, there has been a discernible upward trend in the incidence of RSA, and its etiology is multifaceted and intricate. Pinpointing the root causes of RSA remains an arduous task that urgently demands resolution within the field of reproductive medicine. Through a comprehensive and in-depth analysis of the RSArelated case report, embryonic chromosomal abnormalities were identified as the highestrisk factor. Utilizing preimplantation genetic testing for aneuploidy (PGT-A) technology, an euploid blastocyst was selected for transfer, which led to successful pregnancy and healthy birth. This case holds significant reference value for the clinical treatment of RSA.
Keywords: Recurrent spontaneous abortion, embryonic chromosomal factor, Maternal factor, sperm DNA integrity, External factor
Received: 12 May 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Zhu, Mai, Li, Liao, Ouyang, Chen and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haijing Zhao, Sun Yat-sen Memorial Hospital, Guangzhou, China
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