SYSTEMATIC REVIEW article
Front. Reprod. Health
Sec. Assisted Reproduction
Volume 7 - 2025 | doi: 10.3389/frph.2025.1673144
Acupuncture as an Adjunctive Therapy on Embryo Transfer Day: A Systematic Review and Meta-Analysis of Clinical Pregnancy and Live Birth Outcomes
Provisionally accepted- 1Nanjing University of Chinese Medicine, Nanjing, China
- 2Department of Reproductive Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
- 3Department of Gynecology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
- 4Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
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Background: Acupuncture is frequently employed during the process of embryo transfer. Nevertheless, its precise function in enhancing the likelihood of successful clinical pregnancy or live birth remains ambiguous. Objective: To evaluate the efficacy of acupuncture as a complementary intervention to embryo transfer in managing female subfertility, compare the effects of acupuncture versus sham acupuncture on clinical pregnancy rate in assisted reproductive technology, and clarify the optimal timing of acupuncture administration within in vitro fertilization protocols. Methods: All literatures which described randomized controlled trials of acupuncture during the process of embryo transfer were obtained through searches of Cochrane Central, PubMed and Embase database (all to May 2025). Eleven randomized controlled trials were incorporated into the review. Selection of studies, quality assessment and data extraction were carried out independently by two review authors. Meta analysis was conducted, incorporating both risk ratios and 95% confidence intervals. The primary outcome measure was the clinical pregnancy rate,and the secondary outcome measure was the live birth rate. Results: Eleven studies were selected for review, and nine of these were deemed acceptable based on their discussion of clinical pregnancy rate. By combining the studies and analyzing the results, it was concluded that acupuncture has demonstrated a positive impact on clinical pregnancy rate in contrast with the blank control group (1.25 (1.05-1.50), P = 0.013). A statistical analysis revealed no significant differences between the sham acupuncture group and the acupuncture group (1.01(0.87-1.17), P = 0.907). No statistically significant discrepancy between the Pulus Protocol (1.083(0.946-1.240)) and Delphi Consensus (1.164(0.938-1.445)). Acupuncture has no positive impact on live birth rate during embryo transfer (1.01(0.88-1.15), P = 0.930)). Conclusions: The results of this meta-analysis suggest that a positive correlation has been demonstrated between acupuncture and clinical pregnancy rate during embryo transfer when compared to the blank control group; however, this advantage does not hold when compared to the use of sham acupuncture. The Delphi Consensus revealed no discrepancy in clinical pregnancy rate when compared with the Pulus Protocol. It should be noted that the impact of acupuncture on live birth rate remains to be elucidated.
Keywords: Assisted Reproductive Technology, Embryo Transfer, Infertility, Acupuncture, Clinical pregnancy rate, Live Birth, Systematic review, Meta-analysis
Received: 25 Jul 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Yixin, Jing, Na and Yanyun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Duan Na, Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
Yin Yanyun, Department of Reproductive Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China
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