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ORIGINAL RESEARCH article

Front. Reprod. Health

Sec. Assisted Reproduction

Volume 7 - 2025 | doi: 10.3389/frph.2025.1698380

Gender differences in dealing with recurrent implantation failure after fertility treatments: A foundation for adequate support models

Provisionally accepted
Pascale  Annina StuckiPascale Annina Stucki1Michèle  MeierMichèle Meier2Sarah  Charlotte Maria Di GiacopoSarah Charlotte Maria Di Giacopo2Kurt  BirchlerKurt Birchler2Brigitte  LeenersBrigitte Leeners2*
  • 1UniversitatsSpital Zurich Klinik fur Reproduktions-Endokrinologie, Zürich, Switzerland
  • 2Clinic for Reproductive Endocrinology, University Hospital Zürich, Zürich, Switzerland

The final, formatted version of the article will be published soon.

Abstract Background: Understanding patients' needs is mandatory to optimize medical support. Previous research has identified differences in male and female coping strategies. As embryo implantation failure is a burden for both partners and an intact partnership is beneficial to overcome infertility, support models should adjust the needs of both partners. Psycho-social reactions to recurrent failure of fertility treatments were identi-fied as one of the important but under-researched topics in reproductive medicine and especially knowledge on gender-specific reactions to recurrent implantation failure (RIF) is sparse. We therefore explored male and female emotional/ psychosocial re-actions and coping strategies in RIF. Methods: Women and men from heterosexual couples, where embryo transfers failed to result in pregnancy at least three consecutive times, participated in qualitative semi-structured interviews. Qualitative content analysis was conducted according to the content structuring model of Kuckartz and Rädiker. Results: Dyadic influence in conversation was apparent, with women being more verbally inclined with a vivid narrative style. Men showed a lower intensity and variety of emotional and psychosocial reactions with disappointment being dominant. Greater optimism, little negative impact on quality of life and sexuality were key male findings. Feelings of guilt were significantly more common among women. Unexpectantly, gender differences in coping strategies were less pronounced and shared strategies emerged. Discussion/Conclusions: Experiences with RIF of affected women cannot be directly applied to male partners as men's emotional and psychosocial consequences differ in extent and quality. This gender gap should be considered to improve clinical practice.

Keywords: IVF/ICSI, recurrent implantation failure, Psychosocial Experience, gender differences, qualitative study

Received: 03 Sep 2025; Accepted: 13 Oct 2025.

Copyright: © 2025 Stucki, Meier, Di Giacopo, Birchler and Leeners. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Brigitte Leeners, brigitte.leeners@usz.ch

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