ORIGINAL RESEARCH article
Front. Reprod. Health
Sec. Andrology
This article is part of the Research TopicAdvances in Neuromodulation for Chronic Pain: Mechanisms and Clinical ImplicationsView all 3 articles
Evaluation of a low-intensity pulsed ultrasound for chronic prostatitis type IIIb/chronic pelvic pain syndrome: A randomized controlled trial
Provisionally accepted
- 1Taizhou Central Hospital, Taizhou, China
- 2The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
- 3The First People's Hospital of Pinghu, Pinghu, China
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To investigate and compare the clinical efficacy and safety of low-intensity pulsed ultrasound (LIPUS) in the treatment of chronic prostatitis type IIIb/chronic pelvic pain syndrome (CP/CPPS). In this study, patients diagnosed with CP/CPPS were allocated into two distinct study groups. Group A (n=35) received LIPUS treatment twice a week; Group B (n=30) received tamsulosin sustained-release capsules (0.2mg, once nightly); All groups underwent four weeks of treatment. The endpoints included validated scales: National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), Self-Rating Anxiety Scale (SAS), and International Index of Erectile Function-5 (IIEF-5), assessed at baseline and 4-week post-intervention.Overall, Group A showed a greater improvement in pain symptoms compared to Group B (P<0.05), while Group B demonstrated a greater improvement in urinary symptoms compared to Group A (P<0.05). Assessment of the remaining symptoms revealed no statistically significant differences between the groups (P>0.05). LIPUS and tamsulosin hydrochloride significantly alleviated prostatitis-related symptoms in patients, demonstrating a favorable safety profile during treatment. The combination therapy exhibits promising potential for managing CP/CPPS.
Keywords: Low-intensity pulsed ultrasound, tamsulosin sustained-release, Chronic prostatitis type IIIb/Chronic pelvic pain syndrome, efficacy, Safety
Received: 28 Sep 2025; Accepted: 20 Nov 2025.
Copyright: © 2025 Huang, Liao, Zhao, Liang and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ke Liang, liangke771116@163.com
Bodong Lv, lbd168@zju.edu.cn
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