ORIGINAL RESEARCH article
Front. Syst. Neurosci.
Volume 19 - 2025 | doi: 10.3389/fnsys.2025.1466809
Head Posture Control under Perturbed Conditions in Progressive Supranuclear Palsy Patients
Provisionally accepted
- 1University of Freiburg Medical Center, Freiburg, Germany
- 2LMU Munich University Hospital, Munich, Bavaria, Germany
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In neurodegenerative brain diseases like Progressive Supranuclear Palsy (PSP), clinical studies underscore the crucial role of head motion deficits. Similarly, advanced stage Idiopathic Parkinson's disease (IPD) is known to display significantly altered posture control and balance patterns involving the head segment. This study investigates the relative differences in head control during a perturbed upright stance paradigm between patients affected by PSP and IPD, compared to healthy control subjects using dynamic system modeling. The resulting neural model underlines how PSP primarily affects head control, whereas IPD primarily affects the control of the whole body's center of mass. A neck control model, based on the hypothesis of modular posture control, is proposed to emulate the PSP data in particular. The proposed neural model's characteristics will aid in future patient data analysis, disease progression monitoring, and possible modulation of disease-specific features through therapeutic intervention. For engineering and robotics implementations, uses for strengthened resilience of head stabilization are discussed.
Keywords: Progressive Supranuclear Palsy, Head motion, modelling, feedback control systems, Parameters identification, posture control, human motor control
Received: 18 Jul 2024; Accepted: 02 May 2025.
Copyright: © 2025 Lippi, Maurer, Haverkamp and Kammermeier. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Vittorio Lippi, University of Freiburg Medical Center, Freiburg, Germany
Christoph Maurer, University of Freiburg Medical Center, Freiburg, Germany
Stefan Kammermeier, LMU Munich University Hospital, Munich, 81377, Bavaria, Germany
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