ORIGINAL RESEARCH article
Front. Virol.
Sec. Translational Virology
Volume 5 - 2025 | doi: 10.3389/fviro.2025.1583648
This article is part of the Research TopicExpert Opinions: Save the Microbes to Save the PlanetView all 13 articles
EBV-EBER Associates with CD30 but not HCV-NS3 in T cell Non-Hodgkin Lymphoma
Provisionally accepted
- 1Ulin Hospital, Banjarmasin, South Kalimantan, Indonesia
- 2Duta Wacana Christian University, Yogyakarta, Special Region of Yogyakarta, Indonesia
- 3Dr. Moewardi Hospital, Surakarta, Central Java, Indonesia
- 4Gadjah Mada University, Yogyakarta, Indonesia
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Introduction T-cell lymphoma is one of the contributors to malignancy worldwide, and the prognosis of this cancer was related to CD30 expression. Some T-cell lymphoma, including extranodal NK/T-cell lymphoma (ENKTCL), an aggressive lymphoma, was also commonly associated with Epstein-Barr virus (EBV) infection. EBV can be detected using Epstein-Barr encoded RNA (EBER) in situ hybridization (ISH). In addition, hepatitis C virus (HCV) infection also has a role in the occurrence of Non Hodgkin Lymphoma (NHL). A nonstructural protein of the HCV, NS3, may be involved in lymphoma development.Furthermore, the Epstein-Barr virus has also long been associated with CD30. However, the relationship of CD30 and NS3 was unknown. This research aims to study the relationship between CD30, NS3, and EBER in T-cell lymphoma.Methods Data and paraffin blocks were collected from NHL T cell patients, and 30 samples were chosen for the study after meeting the criteria. The paraffin block was stained with CD30, NS3, and EBER immunohistochemistry and read by two pathologists.From 30 cases, the dominant subtype expressing CD30 was Extranodal Natural Killer T cell Lymphoma (ENKTCL) (84.62%). Twenty (66.7%) samples expressed CD30, six (20%) expressed NS3, and eighteen (60%) samples expressed EBER. There is no significant relationship between NS3 and EBER. Meanwhile, CD30 expression correlated statistically with EBER (P = 0.001).Discussion: CD30 expression in T-cell Non-Hodgkin's Lymphoma was not significantly associated with clinicopathology data in this study. CD30, NS3, and EBER were expressed in T-cell Non-Hodgkin's Lymphoma (NHL). There is relationship between CD30 and EBER, but this study revealed no relationship between NS3 and EBER expression.
Keywords: T-cell, NHL, CD30, NS3, EBER
Received: 26 Feb 2025; Accepted: 13 May 2025.
Copyright: © 2025 Juwita, Saputra, Fiilasari, Hardianti and Anggorowati. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nungki Anggorowati, Gadjah Mada University, Yogyakarta, Indonesia
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