ORIGINAL RESEARCH article

Front. Virol.

Sec. Viral Disease Investigation

Volume 5 - 2025 | doi: 10.3389/fviro.2025.1625855

This article is part of the Research TopicViral Meningitis: recent advances and prospectsView all articles

Overcoming Diagnostic and Data Privacy Challenges in Viral Disease Detection: An Integrated Approach Using Generative AI, Vision Transformers, Explainable AI, and Federated Learning

Provisionally accepted
  • 1Villa college, Malé, Maldives
  • 2Villa College, Malé, Maldives
  • 3Indian Institute of Information Technology, Allahabad, Uttar Pradesh, India – 211012, Allahabad, India
  • 4Indian Institute of Information Technology, Allahabad, India

The final, formatted version of the article will be published soon.

The growing dependence on artificial intelligence (AI) in healthcare has significantly advanced the detection and diagnosis of viral diseases. However, existing AI models encounter key obstacles such as data privacy concerns, limited interpretability, poor generalization, and overfitting, which restrict their practical application and broader adoption. This research tackles these issues by introducing an integrated framework that combines Generative AI, Vision Transformers, Explainable AI (XAI), and Federated Learning (FL) to improve diagnostic accuracy and safeguard data privacy. By utilizing Generative AI, the framework produces synthetic datasets that supplement limited medical data and bolster model resilience. Vision Transformers enhance the precision and efficiency of image-based disease detection. Explainable AI fosters transparency, ensuring that deep learning models' decisions are clear and reliable for healthcare practitioners. Federated Learning facilitates decentralized model training, maintaining patient privacy while enabling collaborative learning across institutions. Experimental findings show that this framework enhances diagnostic accuracy in viral diseases, including COVID-19, while addressing privacy concerns and improving the interpretability of AI systems. This integrated approach offers a secure, transparent, and scalable solution to the critical challenges in AI-driven healthcare, providing real-time, effective disease detection and analysis.

Keywords: Artificial intelligence (AI), Viral Disease Detection, Generative AI, vision transformers, Explainable AI (XAI), Federated learning (FL), Data privacy, deep learning

Received: 09 May 2025; Accepted: 23 Jun 2025.

Copyright: © 2025 Vedaiyan, Srinivasulu and Agrawal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ramchand Vedaiyan, Villa college, Malé, Maldives

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