Macrophages are crucial components of the immune system, involved in a myriad of physiological and pathological processes within the central nervous system and beyond. Interdisciplinary collaboration is vital in advancing our understanding of these cells, their diverse functions, and their implications in various diseases.
Explore the following trending articles in Frontiers in Immunology and Frontiers in Molecular Medicine.
This article explores the multifaceted functions of the C-type lectin receptor Dectin-1, emphasizing the importance of understanding its biology for potential therapeutic applications in various pathological conditions.
This article reviews past and new evidence on the innate immunological disruption behind giant cell arteritis, providing a comprehensive description of disease development from the innate perspective.
This review summarizes challenges and limitations of chimeric antigen receptor (CAR)-T cell therapy targeting cancer stem cells, with particular emphasis on the role of tumor microenvironment and T cell metabolic demands.
This review addresses relevant molecular pathways in mammalian cells discovered to be sensitive to acid-base equilibria, their cellular effects, and how they can cascade into an organism-level manifestation of metabolic syndromes.
This study suggests that T cells equipped with chimeric antigen receptors (CARs) incorporating SIRPα-based spacers effectively target CD19-positive leukemia cells.
This study demonstrates that incorporating an optimized variant of the non-immunogenic cell surface marker EGFRt, called EGFRopt, into engineered cellular therapies enhances its expression and susceptibility to antibody-dependent cellular cytotoxicity.
Read other impactful articles published in Frontiers in Immunology and Frontiers in Molecular Medicine