Apolipoprotein E4 | List of Frontiers open access articles

Opinion

Published on 12 Apr 2019

Human Leukocyte Antigen as a Key Factor in Preventing Dementia and Associated Apolipoprotein E4 Risk

in Alzheimer's Disease and Related Dementias

Lisa M. James
Apostolos P. Georgopoulos

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00082

4,737 views
15 citations

Original Research

Published on 16 Sep 2025

Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers

in Alzheimer's Disease and Related Dementias

Edward Ofori
B. Blair Braden
Kewei Chen
Yi Su
Richard J. Caselli
Eric M. Reiman

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597127

2,984 views

Review

Published on 20 Feb 2025

The role of Apolipoprotein E4 on cognitive impairment in Parkinson’s disease and Parkinsonisms

in Neurodegeneration

Angenelle Eve Rosal
Sarah L. Martin
Antonio P. Strafella

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1515374

4,315 views
7 citations

Original Research

Published on 27 Feb 2024

Modeling sporadic Alzheimer’s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors

in Alzheimer's Disease and Related Dementias

Kiruthika Ganesan
Peggy Rentsch
Alexander Langdon
Luke T. Milham
Bryce Vissel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1357405

7,366 views
5 citations

Original Research

Published on 14 Jun 2023

A computational framework for identifying chemical compounds to bind Apolipoprotein E4 for Alzheimer’s disease intervention

in Translational Systems Biology and In Silico Trials

Tianhua Zhai
Emily Krass
Fangyuan Zhang
Zuyi Huang

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1188430

4,190 views
3 citations

Original Research

Published on 29 Apr 2022

Apolipoprotein E4 Effects a Distinct Transcriptomic Profile and Dendritic Arbor Characteristics in Hippocampal Neurons Cultured in vitro

in Cellular and Molecular Mechanisms of Brain-aging

Jenny R. Diaz
Mitchell Martá-Ariza
Alireza Khodadadi-Jamayran
Adriana Heguy
Aristotelis Tsirigos
Joanna E. Pankiewicz
Patrick M. Sullivan
Martin J. Sadowski

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.845291

6,036 views
9 citations

Mini Review

Published on 14 Jun 2018

APOE and Alzheimer’s Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction

in Alzheimer's Disease and Related Dementias

Jason A. Brandon
Brandon C. Farmer
Holden C. Williams
Lance A. Johnson

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2018.00180

13,245 views
68 citations

Review

Published on 28 Jan 2020

The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”

in Human and Medical Genomics

Vladan P. Bajic
Magbubah Essack
Lada Zivkovic
Alan Stewart
Sonja Zafirovic
Vladimir B. Bajic
Takashi Gojobori
Esma Isenovic
Biljana Spremo-Potparevic

Frontiers in Genetics

doi 10.3389/fgene.2019.01368

11,394 views
33 citations

Systematic Review

Published on 24 Dec 2021

Targeting TREM2 for Parkinson’s Disease: Where to Go?

in Multiple Sclerosis and Neuroimmunology

Xiao-xian Li
Feng Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2021.795036

11,262 views
33 citations

Perspective

Published on 12 Aug 2014

Air pollution and detrimental effects on children’s brain. The need for a multidisciplinary approach to the issue complexity and challenges

in Brain Health and Clinical Neuroscience

Lilian Calderón-Garcidueñas
Ricardo Torres-Jardón
Randy J. Kulesza
Su-Bin Park
Amedeo D’Angiulli

Frontiers in Human Neuroscience

doi 10.3389/fnhum.2014.00613

29,494 views
94 citations

Original Research

Published on 27 Apr 2022

Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions

in Alzheimer's Disease and Related Dementias

Stella A. Belonwu
Yaqiao Li
Daniel G. Bunis
Arjun Arkal Rao
Caroline Warly Solsberg
Tomiko Oskotsky
Alice L. Taubes
Brian Grone
Kelly A. Zalocusky
Gabriela K. Fragiadakis

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.749991

8,222 views
10 citations

Original Research

Published on 28 Sep 2016

A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers

in Neurocognitive Aging and Behavior

Xia Wu
Qing Li
Xinyu Yu
Kewei Chen
Adam S. Fleisher
Xiaojuan Guo
Jiacai Zhang
Eric M. Reiman
Li Yao
Rui Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2016.00231

8,798 views
46 citations

Opinion

Published on 11 Mar 2022

Risk Factors for Severe COVID-19 and Hepatitis C Infections: The Dual Role of Apolipoprotein E4

in Viral Immunology

Felipe B. Lima
Karine C. Bezerra
José Carlos R. Nascimento
Gdayllon C. Meneses
Reinaldo B. Oriá

Frontiers in Immunology

doi 10.3389/fimmu.2022.721793

4,622 views
8 citations

Review

Published on 19 May 2023

APOEε4 and risk of Alzheimer’s disease – time to move forward

in Neurodegeneration

Iliya Lefterov
Nicholas F. Fitz
Yi Lu
Radosveta Koldamova

Frontiers in Neuroscience

doi 10.3389/fnins.2023.1195724

11,664 views
17 citations

Original Research

Published on 21 Sep 2021

Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

in Neurodegeneration

Sabine C. Konings
Laura Torres-Garcia
Isak Martinsson
Gunnar K. Gouras

Frontiers in Neuroscience

doi 10.3389/fnins.2021.734001

12,793 views
40 citations

Original Research

Published on 16 Sep 2022

Osteoporosis is associated with elevated baseline cerebrospinal fluid biomarkers and accelerated brain structural atrophy among older people

in Neurocognitive Aging and Behavior

Hao Pan
Jiali Cao
Congcong Wu
Furong Huang
Peng Wu
Junzhe Lang
Yangbo Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.958050

3,627 views
2 citations

Articles

Human Leukocyte Antigen as a Key Factor in Preventing Dementia and Associated Apolipoprotein E4 Risk

Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers

The role of Apolipoprotein E4 on cognitive impairment in Parkinson’s disease and Parkinsonisms

Modeling sporadic Alzheimer’s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors

A computational framework for identifying chemical compounds to bind Apolipoprotein E4 for Alzheimer’s disease intervention

Apolipoprotein E4 Effects a Distinct Transcriptomic Profile and Dendritic Arbor Characteristics in Hippocampal Neurons Cultured in vitro

APOE and Alzheimer’s Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction

The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”

Targeting TREM2 for Parkinson’s Disease: Where to Go?

Air pollution and detrimental effects on children’s brain. The need for a multidisciplinary approach to the issue complexity and challenges

Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions

A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers

Risk Factors for Severe COVID-19 and Hepatitis C Infections: The Dual Role of Apolipoprotein E4

APOEε4 and risk of Alzheimer’s disease – time to move forward

Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

Osteoporosis is associated with elevated baseline cerebrospinal fluid biomarkers and accelerated brain structural atrophy among older people