Bedaquiline | List of Frontiers open access articles

Original Research

Published on 25 Sep 2025

Country-level heterogeneity in MDR-TB drug susceptibility supports country-specific policy development

in Epidemiology of Tuberculosis

Naomi M. Fuller
Nicholas G. Davies
Timothy D. McHugh
Gwenan M. Knight

Frontiers in Tuberculosis

doi 10.3389/ftubr.2025.1667354

1,233 views

Original Research

Published on 26 Feb 2021

Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3-Kinase

in Microbial Immunology

Gregory R. Tintinger
Annette J. Theron
Helen C. Steel
Moloko C. Cholo
Jan G. Nel
Charles Feldman
Ronald Anderson

Frontiers in Immunology

doi 10.3389/fimmu.2020.621148

4,905 views
4 citations

Original Research

Published on 25 Feb 2021

In vitro Antibacterial Activity of an FDA-Approved H+-ATPase Inhibitor, Bedaquiline, Against Streptococcus mutans in Acidic Milieus

in Antimicrobials, Resistance and Chemotherapy

Meng Zhang
Wenqian Yu
Shujing Zhou
Bing Zhang
Edward Chin Man Lo
Xin Xu
Dongjiao Zhang

Frontiers in Microbiology

doi 10.3389/fmicb.2021.647611

5,118 views
7 citations

Original Research

Published on 04 Oct 2023

Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline

in Experimental Pharmacology and Drug Discovery

Yangming Ding
Haiting Liu
Furun Wang
Lei Fu
Hui Zhu
Shuang Fu
Ning Wang
Xiaomei Zhuang
Yu Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1154780

3,570 views
3 citations

Original Research

Published on 27 Mar 2023

Population pharmacokinetics and model-based dosing evaluation of bedaquiline in multidrug-resistant tuberculosis patients

in Pharmacology of Infectious Diseases

Ge Shao
Ziwei Bao
Lina Davies Forsman
Jakob Paues
Jim Werngren
Katarina Niward
Thomas Schön
Judith Bruchfeld
Jan-Willem Alffenaar
Yi Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1022090

5,910 views
11 citations

Original Research

Published on 27 May 2022

Whole Genome Sequencing Identifies Novel Mutations Associated With Bedaquiline Resistance in Mycobacterium tuberculosis

in Clinical and Diagnostic Microbiology and Immunology

Qinglong Guo
Jing Bi
Qiao Lin
Taosheng Ye
Zhongyuan Wang
Zhaoqin Wang
Lei Liu
Guoliang Zhang

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2022.807095

8,895 views
33 citations

Review

Published on 10 Jan 2024

Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis

in Infectious Diseases: Pathogenesis and Therapy

Md Mahmudul Islam
Md Shah Alam
Zhiyong Liu
Mst Sumaia Khatun
Buhari Yusuf
H. M. Adnan Hameed
Xirong Tian
Chiranjibi Chhotaray
Rajesh Basnet
Haftay Abraha

Frontiers in Medicine

doi 10.3389/fmed.2023.1304857

11,442 views
20 citations

Perspective

Published on 11 Dec 2017

Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis

in Antimicrobials, Resistance and Chemotherapy

Divakar Sharma
Yogesh K. Dhuriya
Nirmala Deo
Deepa Bisht

Frontiers in Microbiology

doi 10.3389/fmicb.2017.02452

9,052 views
43 citations

Original Research

Published on 22 Oct 2021

Primary Bedaquiline Resistance Among Cases of Drug-Resistant Tuberculosis in Taiwan

in Antimicrobials, Resistance and Chemotherapy

Sheng-Han Wu
Hsin-Hua Chan
Hseuh-Chien Hsiao
Ruwen Jou

Frontiers in Microbiology

doi 10.3389/fmicb.2021.754249

7,368 views
39 citations

Review

Published on 13 Jun 2023

Advances of new drugs bedaquiline and delamanid in the treatment of multi-drug resistant tuberculosis in children

in Clinical and Diagnostic Microbiology and Immunology

Hanzhao Zhu
Xintong Zhou
Zengfang Zhuang
Lianju Li
Jing Bi
Kaixia Mi

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2023.1183597

11,217 views
17 citations

Original Research

Published on 30 May 2024

Identification of urine biomarkers predictive of prolonged QTc interval in multidrug-resistant tuberculosis patients treated with bedaquiline

in Pharmacology of Infectious Diseases

Jiajia Yu
Weicong Ren
Jinfeng Yuan
Rongmei Liu
Liping Ma
Shenjie Tang
Yu Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1362544

2,103 views
1 citation

Original Research

Published on 10 Nov 2022

2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli

in Experimental Pharmacology and Drug Discovery

M. Korycka-Machała
M. Kawka
J. Lach
R. Płocińska
A. Bekier
B. Dziadek
A. Brzostek
P. Płociński
D. Strapagiel
M. Szczesio

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1004632

6,628 views
7 citations

Review

Published on 09 Feb 2026

Drug resistance mechanisms in Mycobacterium tuberculosis infection and challenges in vaccine development

in Pharmacology of Infectious Diseases

Shuying Zhang
Juan Cheng
Yuanyuan Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1762214

613 views

Original Research

Published on 10 Jun 2024

Development of bedaquiline nanoemulsions intended for paediatric multidrug-resistant tuberculosis: excipient selection and preformulation studies

in Nano-Based Drug Delivery

Taiwo Oreoluwa Ajayi
Madan Sai Poka
Bwalya Angel Witika

Frontiers in Medical Technology

doi 10.3389/fmedt.2024.1388113

3,968 views
5 citations

Original Research

Published on 12 Aug 2024

Rel-dependent decrease in the expression of ribosomal protein genes by inhibition of the respiratory electron transport chain in Mycobacterium smegmatis

in Microbial Physiology and Metabolism

Na-Kyeong Kim
Jong-Eun Baek
Ye-Jin Lee
Yuna Oh
Jeong-Il Oh

Frontiers in Microbiology

doi 10.3389/fmicb.2024.1448277

2,774 views
3 citations

Original Research

Published on 17 Sep 2020

In vitro Study of Bedaquiline Resistance in Mycobacterium tuberculosis Multi-Drug Resistant Clinical Isolates

in Antimicrobials, Resistance and Chemotherapy

Giulia Degiacomi
José Camilla Sammartino
Virginia Sinigiani
Paola Marra
Alice Urbani
Maria Rosalia Pasca

Frontiers in Microbiology

doi 10.3389/fmicb.2020.559469

15,708 views
62 citations

Articles

Country-level heterogeneity in MDR-TB drug susceptibility supports country-specific policy development

Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3-Kinase

In vitro Antibacterial Activity of an FDA-Approved H+-ATPase Inhibitor, Bedaquiline, Against Streptococcus mutans in Acidic Milieus

Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline

Population pharmacokinetics and model-based dosing evaluation of bedaquiline in multidrug-resistant tuberculosis patients

Whole Genome Sequencing Identifies Novel Mutations Associated With Bedaquiline Resistance in Mycobacterium tuberculosis

Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis

Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis

Primary Bedaquiline Resistance Among Cases of Drug-Resistant Tuberculosis in Taiwan

Advances of new drugs bedaquiline and delamanid in the treatment of multi-drug resistant tuberculosis in children

Identification of urine biomarkers predictive of prolonged QTc interval in multidrug-resistant tuberculosis patients treated with bedaquiline

2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli

Drug resistance mechanisms in Mycobacterium tuberculosis infection and challenges in vaccine development

Development of bedaquiline nanoemulsions intended for paediatric multidrug-resistant tuberculosis: excipient selection and preformulation studies

Rel-dependent decrease in the expression of ribosomal protein genes by inhibition of the respiratory electron transport chain in Mycobacterium smegmatis

In vitro Study of Bedaquiline Resistance in Mycobacterium tuberculosis Multi-Drug Resistant Clinical Isolates