Chronic Lower Back Pain | List of Frontiers open access articles

Original Research

Published on 10 Dec 2025

From randomized controlled trial to real world clinical evidence: effectiveness and engagement of in-home virtual reality pain treatment for chronic pain in older adults

in Geriatric Pain

Todd Maddox
Josh Sackman
Emily Judge
Roselani Maddox
Robert Bonakdar
Beth D. Darnall

Frontiers in Pain Research

doi 10.3389/fpain.2025.1694007

1,370 views

Original Research

Published on 06 Mar 2024

Research on the multidimensional brain remodeling mechanisms at the level of brain regions, circuits, and networks in patients with chronic lower back pain caused by lumbar disk herniation

in Brain Imaging Methods

Yuan-Dong Mei
Hang Gao
Wei-Fei Chen
Wei Zhu
Chen Gu
Jun-Peng Zhang
Ji-Ming Tao
Xu-Yun Hua

Frontiers in Neuroscience

doi 10.3389/fnins.2024.1357269

4,549 views
9 citations

Case Report

Published on 18 May 2022

Does Virtual Reality Feedback at Infra-Low Frequency Improve Centralized Pain With Comorbid Insomnia While Mitigating Risks for Sedative Use Disorder?: A Case Report

in Brain Health and Clinical Neuroscience

Nnamdi Orakpo
Chujun Yuan
Olanrewaju Olukitibi
Jeff Burdette
Kim Arrington

Frontiers in Human Neuroscience

doi 10.3389/fnhum.2022.915376

5,206 views
5 citations

Systematic Review

Published on 02 Feb 2026

In water or on land? A network meta-analysis of aquatic and land-based exercise interventions for pain and disability in chronic lower back pain

in Rheumatology

Hao Wu
Penglin Diao
Juan Del Coso
Xiaoyu Liu
Yiwei Min
Ruimeng Ran
Bopeng Qiu
Yinkai Zhang
Ziyu Wang
Carl Petersen

Frontiers in Medicine

doi 10.3389/fmed.2026.1739263

664 views

Editorial

Published on 14 Mar 2025

Editorial: Adaptive coping strategies for rehabilitation of people with non-specific chronic lower back pain or non-specific chronic neck pain

in Rehabilitation for Musculoskeletal Conditions

Chinonso Nwamaka Igwesi-Chidobe
Loveness Anila Nkhata

Frontiers in Rehabilitation Sciences

doi 10.3389/fresc.2025.1551777

1,767 views
1 citation

Case Report

Published on 01 Nov 2023

Case Report: Guanfacine and methylphenidate improved chronic lower back pain in autosomal dominant polycystic kidney disease with comorbid attention deficit hyperactivity disorder and autism spectrum disorder

in Pediatric Nephrology

Satoshi Kasahara
Shoichiro Kanda
Miwako Takahashi
Mao Fujioka
Taito Morita
Ko Matsudaira
Naoko Sato
Motoshi Hattori
Toshimitsu Momose
Shin-Ichi Niwa

Frontiers in Pediatrics

doi 10.3389/fped.2023.1283823

7,596 views
8 citations

Original Research

Published on 13 Oct 2023

Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients

in Translational Neuroscience

George Kenefati
Mika M. Rockholt
Deborah Ok
Michael McCartin
Qiaosheng Zhang
Guanghao Sun
Julia Maslinski
Aaron Wang
Baldwin Chen
Erich P. Voigt

Frontiers in Neuroscience

doi 10.3389/fnins.2023.1278183

7,389 views
17 citations

Original Research

Published on 30 Nov 2020

Increased Left Putamen Volume Correlates With Pain in Ankylosing Spondylitis Patients

in Applied Neuroimaging

Kelei Hua
Peijun Wang
Zhihong Lan
Meng Li
Wenkai Zhao
Tianyue Wang
Shumei Li
Xiaofen Ma
Chao Li
Shishun Fu

Frontiers in Neurology

doi 10.3389/fneur.2020.607646

3,381 views
6 citations

Review

Published on 24 Jun 2025

Virtual reality-delivered skills-based therapy for chronic lower back pain: from proof-of-concept to FDA authorization to clinical implementation in-home and beyond

in Virtual Reality in Medicine

Todd Maddox
Josh Sackman
Matthew Stoudt
Michael Chibbaro
Emily Judge
Regan Rothery
Jesse Donini
Roselani Maddox
Beth D. Darnall

Frontiers in Virtual Reality

doi 10.3389/frvir.2025.1613188

4,858 views
3 citations

Review

Published on 14 Mar 2022

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration

in Molecular and Cellular Pathology

Frances C. Bach
Deepani W. Poramba-Liyanage
Frank M. Riemers
Jerome Guicheux
Anne Camus
James C. Iatridis
Danny Chan
Keita Ito
Christine L. Le Maitre
Marianna A. Tryfonidou

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.780749

15,521 views
49 citations

Systematic Review

Published on 06 Jan 2026

Brain functional changes following spinal manipulation therapy in patients with lumbar disc herniation and chronic low back pain: a scoping review

in Neurorehabilitation

Lizhen Cao
Jing Shu
Bibao Li

Frontiers in Neurology

doi 10.3389/fneur.2025.1712320

1,168 views

Mini Review

Published on 05 May 2023

Transcranial magnetic stimulation for the treatment of chronic low back pain: a narrative review

in Non-Pharmacological Treatment of Pain

Camille Olechowski
Maricar Gener
Rohit Aiyer
Nicholas Mischel

Frontiers in Pain Research

doi 10.3389/fpain.2023.1092158

7,475 views
7 citations

Original Research

Published on 17 Nov 2016

Cortical Sensorimotor Processing of Painful Pressure in Patients with Chronic Lower Back Pain—An Optical Neuroimaging Study using fNIRS

in Brain Imaging and Stimulation

Andrea Vrana
Michael L. Meier
Sabina Hotz-Boendermaker
Barry K. Humphreys
Felix Scholkmann

Frontiers in Human Neuroscience

doi 10.3389/fnhum.2016.00578

8,107 views
23 citations

Articles

From randomized controlled trial to real world clinical evidence: effectiveness and engagement of in-home virtual reality pain treatment for chronic pain in older adults

Research on the multidimensional brain remodeling mechanisms at the level of brain regions, circuits, and networks in patients with chronic lower back pain caused by lumbar disk herniation

Does Virtual Reality Feedback at Infra-Low Frequency Improve Centralized Pain With Comorbid Insomnia While Mitigating Risks for Sedative Use Disorder?: A Case Report

In water or on land? A network meta-analysis of aquatic and land-based exercise interventions for pain and disability in chronic lower back pain

Editorial: Adaptive coping strategies for rehabilitation of people with non-specific chronic lower back pain or non-specific chronic neck pain

Case Report: Guanfacine and methylphenidate improved chronic lower back pain in autosomal dominant polycystic kidney disease with comorbid attention deficit hyperactivity disorder and autism spectrum disorder

Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients

Increased Left Putamen Volume Correlates With Pain in Ankylosing Spondylitis Patients

Virtual reality-delivered skills-based therapy for chronic lower back pain: from proof-of-concept to FDA authorization to clinical implementation in-home and beyond

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration

Brain functional changes following spinal manipulation therapy in patients with lumbar disc herniation and chronic low back pain: a scoping review

Transcranial magnetic stimulation for the treatment of chronic low back pain: a narrative review

Cortical Sensorimotor Processing of Painful Pressure in Patients with Chronic Lower Back Pain—An Optical Neuroimaging Study using fNIRS