Combinatorial Optimization Problem | List of Frontiers open access articles

Original Research

Published on 12 May 2026

Phase I clinical trials for cardiovascular diseases in Europe: analysis of trends, distribution, and regulatory context

in Drugs Outcomes Research and Policies

Stefano Grosdani
Arianna Bertolani
Giorgio Reggiardo
Nicola Cosentino
Giancarlo Marenzi
Piergiuseppe Agostoni
Giulio Pompilio
Arianna Pani
Marco Scatigna

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1774988

265 views

Systematic Review

Published on 12 May 2026

Associations between prevalent unhealthy lifestyles and the gut microbiota: a comprehensive multi-database bibliometric analysis of pathogenic mechanisms and clinical trajectories

in Gastroenterology

Xiao-Jie Zhou
Jun-Lei Chen
Chen-Feng Hu
Zhang-Kai Li
Hong-Bo Zheng
Tu-Nan Ding
Yan Chen
Yan Zhu
Jia-Ni Li
Qiang Fu

Frontiers in Medicine

doi 10.3389/fmed.2026.1834916

205 views

Original Research

Published on 12 May 2026

Treg-derived IFN-γ supports the differentiation of Th1-Treg in tumor immunity and autoimmunity

in T Cell Biology

Ayumi Kuratani
Masaaki Okamoto
Sekar Arumsari
Takashi Kobayashi
Miwa Sasai
Masahiro Yamamoto

Frontiers in Immunology

doi 10.3389/fimmu.2026.1756194

257 views

Original Research

Published on 12 May 2026

Organic acids target key virulence factors of Aeromonas hydrophila to reduce infection in vitro

in Aquatic Microbiology

Florica Morariu
Igori Balta
Lavinia Stef
Ioan Pet
Sorin Morariu
Nicolae Corcionivoschi
Ducu Stef

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1809130

166 views

Original Research

Published on 12 May 2026

Diagnosis, treatment, and biosafety protection of imported highly pathogenic cutaneous fungal infection: a case-based study of cutaneous coccidioidomycosis

in Infectious Diseases: Epidemiology and Prevention

Yuhua Weng
Zehu Liu
Xiujiao Xia

Frontiers in Public Health

doi 10.3389/fpubh.2026.1833316

284 views

Original Research

Published on 12 May 2026

Effects of an active exoskeleton on the muscle activity of the erector spinae and biceps femoris muscles during lifting with symmetric stoop and squat technique

in Biomechanics

Jens Hasenmaier
Tobias Siebert
Dominik Mayer
Norman Stutzig

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1631785

282 views

Original Research

Published on 12 May 2026

Assessing perceived needs for telepathology implementation in Colombia: a baseline study from Red GLORIA

in Health Technology Implementation

Marcela Gomez-Suarez
Gabriel E. Acelas-Gonzalez
Andrés Mosquera-Zamudio
Julian C. Riaño-Moreno
Gabriela Guerron-Gomez
Maria Camila Restrepo-Guarnizo
Rafael Parra-Medina

Frontiers in Digital Health

doi 10.3389/fdgth.2026.1765310

277 views

Original Research

Published on 12 May 2026

Enhancement of genetic potential for soil carbon and nitrogen cycling by organic fertilizer substitution improves the ecological environment for licorice cultivation

in Microbiological Chemistry and Geomicrobiology

Guochen Liao
Jiancai Xiao
Boyu Zhang
Sheng Wang
Xiufu Wan
Chengcai Zhang
Chaogeng Lyu
Binbin Yan
Yuping Zhao
Chuanzhi Kang

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1758116

193 views

Original Research

Published on 12 May 2026

Genotoxicity and gene expression modulation associated with the use of DDVP antiparasitic drugs in aquaculture on Danio rerio

in Parasitology

Ad Viralkumar
Lukram Sushil Singh
Gowhar Iqbal
Vivek Shrivastava
Ridhdhisa R. Barad
Krinal Mori
Sujit Kumar

Frontiers in Veterinary Science

doi 10.3389/fvets.2026.1832183

267 views

Original Research

Published on 12 May 2026

Development and validation of a MODS risk prediction model for organophosphorus poisoning patients

in Intensive Care Medicine and Anesthesiology

Helong Yu
Ke Wang
Huisong Wu
Fangfang Li

Frontiers in Medicine

doi 10.3389/fmed.2026.1791307

549 views

Original Research

Published on 12 May 2026

Application of modular surgical supply kits to preoperative preparation for thyroid surgery: a randomized controlled study

in Otorhinolaryngology - Head and Neck Surgery

Ping-ping Chen
Hong Gu
Zhuping Wang
Ting-ting Li

Frontiers in Surgery

doi 10.3389/fsurg.2026.1790245

680 views

Case Report

Published on 12 May 2026

Case Report: Oral glutamatergic augmentation for trauma-related disorders with fluoxetine-/bupropion-potentiated dextromethorphan ± piracetam: a four-patient case series

in Anxiety and Stress Disorders

Ngo Cheung

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1752101

239 views

Editorial

Published on 12 May 2026

Editorial: Genetic and molecular markers in human viral infections

in Virus and Host

Maria Alice Freitas Queiroz
Jordana Grazziela Coelho-dos-Reis
Antonio Carlos Rosário Vallinoto

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1854930

126 views

Original Research

Published on 12 May 2026

LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis

in Molecular and Cellular Oncology

Mengfan Yang
Pei Liu
Hongjun Zhang
Xun Tang
Xiang Hong
Yujiao Liu
Meichao Deng
Xiaolin Tu
Gaohai Shao

Frontiers in Oncology

doi 10.3389/fonc.2026.1832247

205 views

Original Research

Published on 12 May 2026

Cause-specific hazards of antiretroviral therapy programmatic adherence, defaulting and mortality among HIV/AIDS patients who had attained CD4 count recovery after antiretroviral therapy initiation in South Africa

in HIV and STIs

Chiedza Elvina Mashiri
Knowledge Chinhamu
Jesca Mercy Batidzirai
Retius Chifurira

Frontiers in Reproductive Health

doi 10.3389/frph.2026.1797297

216 views

Original Research

Published on 12 May 2026

Multi-omics investigation of perineural invasion in head and neck squamous cell carcinoma: neuroimmune mechanisms and clinical implications

in Cancer Immunity and Immunotherapy

Muling Deng
Yuhao Lin
Chenyu Fang
Jiaqi Cai
Chuanben Chen
Jianming Ding

Frontiers in Immunology

doi 10.3389/fimmu.2026.1792836

147 views

Articles

Phase I clinical trials for cardiovascular diseases in Europe: analysis of trends, distribution, and regulatory context

Associations between prevalent unhealthy lifestyles and the gut microbiota: a comprehensive multi-database bibliometric analysis of pathogenic mechanisms and clinical trajectories

Treg-derived IFN-γ supports the differentiation of Th1-Treg in tumor immunity and autoimmunity

Organic acids target key virulence factors of Aeromonas hydrophila to reduce infection in vitro

Diagnosis, treatment, and biosafety protection of imported highly pathogenic cutaneous fungal infection: a case-based study of cutaneous coccidioidomycosis

Effects of an active exoskeleton on the muscle activity of the erector spinae and biceps femoris muscles during lifting with symmetric stoop and squat technique

Assessing perceived needs for telepathology implementation in Colombia: a baseline study from Red GLORIA

Enhancement of genetic potential for soil carbon and nitrogen cycling by organic fertilizer substitution improves the ecological environment for licorice cultivation

Genotoxicity and gene expression modulation associated with the use of DDVP antiparasitic drugs in aquaculture on Danio rerio

Development and validation of a MODS risk prediction model for organophosphorus poisoning patients

Application of modular surgical supply kits to preoperative preparation for thyroid surgery: a randomized controlled study

Case Report: Oral glutamatergic augmentation for trauma-related disorders with fluoxetine-/bupropion-potentiated dextromethorphan ± piracetam: a four-patient case series

Editorial: Genetic and molecular markers in human viral infections

LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis

Cause-specific hazards of antiretroviral therapy programmatic adherence, defaulting and mortality among HIV/AIDS patients who had attained CD4 count recovery after antiretroviral therapy initiation in South Africa

Multi-omics investigation of perineural invasion in head and neck squamous cell carcinoma: neuroimmune mechanisms and clinical implications