Creatine Supplementation | List of Frontiers open access articles

Original Research

Published on 07 Dec 2022

Creatine modulates cellular energy metabolism and protects against cancer cachexia-associated muscle wasting

in Experimental Pharmacology and Drug Discovery

Lulu Wei
Ranran Wang
Kai Lin
Xiaolu Jin
Li Li
Junaid Wazir
Wenyuan Pu
Panpan Lian
Renwei Lu
Shiyu Song

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1086662

13,810 views
13 citations

Original Research

Published on 30 Mar 2023

Creatine in the fetal brain: A regional investigation of acute global hypoxia and creatine supplementation in a translational fetal sheep model

in Cellular Neuropathology

Nhi T. Tran
Anna M. Muccini
Nadia Hale
Mary Tolcos
Rod J. Snow
David W. Walker
Stacey J. Ellery

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2023.1154772

6,034 views
9 citations

Review

Published on 12 Jan 2026

Creatine supplementation and exercise in aging: a narrative review of the muscle–brain axis and its impact on cognitive and physical health

in Nutrition and Metabolism

Nana Li

Frontiers in Nutrition

doi 10.3389/fnut.2025.1687719

7,474 views

Review

Published on 24 Apr 2018

Creatine Supplementation During Resistance Training Does Not Lead to Greater Bone Mineral Density in Older Humans: A Brief Meta-Analysis

in Sport and Exercise Nutrition

Scott C. Forbes
Philip D. Chilibeck
Darren G. Candow

Frontiers in Nutrition

doi 10.3389/fnut.2018.00027

27,235 views
24 citations

Review

Published on 28 Nov 2018

Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review

in Sport and Exercise Nutrition

Andrew R. Jagim
Richard A. Stecker
Patrick S. Harty
Jacob L. Erickson
Chad M. Kerksick

Frontiers in Nutrition

doi 10.3389/fnut.2018.00115

327,533 views
27 citations

Mini Review

Published on 23 Jul 2025

Creatine supplementation and muscle-brain axis: a new possible mechanism?

in Sport and Exercise Nutrition

Felipe Ribeiro
Scott C. Forbes
Darren G. Candow
Pedro Perim
Fabio Santos Lira
Antonio Herbert Lancha
José C. Rosa Neto

Frontiers in Nutrition

doi 10.3389/fnut.2025.1579204

29,759 views
4 citations

Review

Published on 09 Aug 2019

Variables Influencing the Effectiveness of Creatine Supplementation as a Therapeutic Intervention for Sarcopenia

in Sport and Exercise Nutrition

Darren G. Candow
Scott C. Forbes
Philip D. Chilibeck
Stephen M. Cornish
Jose Antonio
Richard B. Kreider

Frontiers in Nutrition

doi 10.3389/fnut.2019.00124

31,630 views
66 citations

Brief Research Report

Published on 18 Aug 2023

Creatine supplementation enhances anti-tumor immunity by promoting adenosine triphosphate production in macrophages

in Nutritional Immunology

Zhenzi Peng
Suguru Saito

Frontiers in Immunology

doi 10.3389/fimmu.2023.1176956

34,140 views
21 citations

Systematic Review

Published on 08 May 2026

Does creatine affect lipid profile? a systematic review and meta-analysis of randomized placebo-controlled trials

in Sport and Exercise Nutrition

Fabiana V. M. Gimenez
Natalia Pasternak
Lívia Santesso
Lívia M. A. da Silva
Lara A. Girotto
Bruno M. Candeloro
Sandra Maria Barbalho
Andrey A. Porto
Rodrigo D. Raimundo
Luiz Carlos de Abreu

Frontiers in Nutrition

doi 10.3389/fnut.2026.1787009

1,218 views

Original Research

Published on 10 Apr 2019

Creatine Supplementation Improves Phosphagen Energy Pathway During Supramaximal Effort, but Does Not Improve Anaerobic Capacity or Performance

in Exercise Physiology

Rodrigo de Araujo Bonetti de Poli
Luan Henrique Roncada
Elvis de Souza Malta
Guilherme Giannini Artioli
Rômulo Bertuzzi
Alessandro Moura Zagatto

Frontiers in Physiology

doi 10.3389/fphys.2019.00352

15,628 views
19 citations

Review

Published on 07 Nov 2025

The role of brain creatine in behavioral health conditions

in Mood Disorders

Ellie S. Han
James R. Yancey
Deborah A. Yurgelun-Todd
Douglas G. Kondo
Danielle J. Boxer
Perry F. Renshaw

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1667639

10,280 views

Review

Published on 20 May 2022

Creatine O'Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance?

in Sport and Exercise Nutrition

Darren G. Candow
Scott C. Forbes
Michael D. Roberts
Brian D. Roy
Jose Antonio
Abbie E. Smith-Ryan
Eric S. Rawson
Bruno Gualano
Hamilton Roschel

Frontiers in Sports and Active Living

doi 10.3389/fspor.2022.893714

112,840 views
17 citations

Systematic Review

Published on 08 Apr 2026

Creatine supplementation in young men under resistance versus non-resistance training: a systematic review and meta-analysis of strength, performance, and lean mass

in Sport and Exercise Nutrition

Jinfa Gu
Yan Li
Jialing Xiao
Yu Zhang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1800546

3,073 views

Opinion

Published on 04 Apr 2025

Creatine supplementation is safe, beneficial throughout the lifespan, and should not be restricted

in Nutritional Epidemiology

Richard B. Kreider
Andrew R. Jagim
Jose Antonio
Douglas S. Kalman
Chad M. Kerksick
Jeffrey R. Stout
Robert Wildman
Rick Collins
Diego A. Bonilla

Frontiers in Nutrition

doi 10.3389/fnut.2025.1578564

81,298 views
8 citations

Original Research

Published on 28 Mar 2019

Dietary Creatine Supplementation in Gilthead Seabream (Sparus aurata) Increases Dorsal Muscle Area and the Expression of myod1 and capn1 Genes

in Experimental Endocrinology

Lourenço Ramos-Pinto
Graciliana Lopes
Vera Sousa
L. Filipe C. Castro
Denise Schrama
Pedro Rodrigues
Luísa M. P. Valente

Frontiers in Endocrinology

doi 10.3389/fendo.2019.00161

6,692 views
27 citations

Systematic Review

Published on 12 Jul 2024

The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis

in Nutrition, Psychology and Brain Health

Chen Xu
Siyuan Bi
Wenxin Zhang
Lin Luo

Frontiers in Nutrition

doi 10.3389/fnut.2024.1424972

215,118 views
35 citations

Articles

Creatine modulates cellular energy metabolism and protects against cancer cachexia-associated muscle wasting

Creatine in the fetal brain: A regional investigation of acute global hypoxia and creatine supplementation in a translational fetal sheep model

Creatine supplementation and exercise in aging: a narrative review of the muscle–brain axis and its impact on cognitive and physical health

Creatine Supplementation During Resistance Training Does Not Lead to Greater Bone Mineral Density in Older Humans: A Brief Meta-Analysis

Safety of Creatine Supplementation in Active Adolescents and Youth: A Brief Review

Creatine supplementation and muscle-brain axis: a new possible mechanism?

Variables Influencing the Effectiveness of Creatine Supplementation as a Therapeutic Intervention for Sarcopenia

Creatine supplementation enhances anti-tumor immunity by promoting adenosine triphosphate production in macrophages

Does creatine affect lipid profile? a systematic review and meta-analysis of randomized placebo-controlled trials

Creatine Supplementation Improves Phosphagen Energy Pathway During Supramaximal Effort, but Does Not Improve Anaerobic Capacity or Performance

The role of brain creatine in behavioral health conditions

Creatine O'Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance?

Creatine supplementation in young men under resistance versus non-resistance training: a systematic review and meta-analysis of strength, performance, and lean mass

Creatine supplementation is safe, beneficial throughout the lifespan, and should not be restricted

Dietary Creatine Supplementation in Gilthead Seabream (Sparus aurata) Increases Dorsal Muscle Area and the Expression of myod1 and capn1 Genes

The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis