Cyp3a4 Expression | List of Frontiers open access articles

Original Research

Published on 21 Feb 2017

Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor

in Ethnopharmacology

Naoto Okada
Aki Murakami
Shiori Urushizaki
Misa Matsuda
Kazuyoshi Kawazoe
Keisuke Ishizawa

Frontiers in Pharmacology

doi 10.3389/fphar.2017.00084

7,386 views
19 citations

Original Research

Published on 26 Nov 2025

Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity

in Drug Metabolism and Transport

Muluneh M. Fashe
Jonghwa Lee
Joseph T. Grieco
John K. Fallon
Ian R. Mulrenin
Megan N. Gower
Klarissa D. Jackson
Kim A. Boggess
Craig R. Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702419

1,215 views

Review

Published on 25 Feb 2013

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the “Missing Heritability” Problem

in Pharmacogenetics and Pharmacogenomics

Kathrin Klein
Ulrich M Zanger

Frontiers in Genetics

doi 10.3389/fgene.2013.00012

38,314 views
209 citations

Original Research

Published on 28 Jun 2021

Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity

in Cancer Metabolism

Alican Özkan
Danielle L. Stolley
Erik N. K. Cressman
Matthew McMillin
Sharon DeMorrow
Thomas E. Yankeelov
Marissa Nichole Rylander

Frontiers in Oncology

doi 10.3389/fonc.2021.662135

8,359 views
44 citations

Original Research

Published on 19 Sep 2018

The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity

in Predictive Toxicology

Zhuo-Qing Li
Li-Long Jiang
Dong-Sheng Zhao
Jing Zhou
Ling-Li Wang
Zi-Tian Wu
Xian Zheng
Zi-Qi Shi
Ping Li
Hui-Jun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01033

6,638 views
29 citations

Original Research

Published on 05 Jul 2023

Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam

in Drug Metabolism and Transport

Muluneh M. Fashe
Taryn A. Miner
John K. Fallon
Amanda P. Schauer
Craig Sykes
Philip C. Smith
Craig R. Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1218703

4,116 views
10 citations

Original Research

Published on 05 Apr 2022

Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes

in Ethnopharmacology

Alinafe Magret Kapelemera
Yow-Shieng Uang
Li-Hsuan Wang
Tien-Yuan Wu
Fang-Yu Lee
Li Tai
Ching-Chiung Wang
Chia-Jung Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2022.858007

6,331 views
10 citations

Articles

Extracts of Immature Orange (Aurantii fructus immaturus) and Citrus Unshiu Peel (Citri unshiu pericarpium) Induce P-Glycoprotein and Cytochrome P450 3A4 Expression via Upregulation of Pregnane X Receptor

Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the “Missing Heritability” Problem

Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity

The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity

Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam

Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes