Defunctionalization | List of Frontiers open access articles

Original Research

Published on 04 Mar 2026

Integrative biology shows DPP4 affects inflammatory response to eclampsia and cell model growth via p65/NLRP3/ASC/Caspase-1 pathway

in Immunogenetics

Zhimin Bian
Li Hao
Rongjuan Yang
Jianghui Sun

Frontiers in Genetics

doi 10.3389/fgene.2026.1775026

137 views

Original Research

Published on 04 Mar 2026

Protective effects of Lagerstroemia speciosa against paracetamol-induced renal and testicular toxicity in rats via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms

in Regulatory Toxicology

Nagham E. Elsheshtawy
Engy F. Risha
Fatma M. Abdelhamid
Bodour S. Rajab
Rehab Bagadood
Bayan Bokhari
Ghadir Sindi
Ahmed I. Ateya
Shaymaa Rezk
Mohamed E. El-Boshy

Frontiers in Toxicology

doi 10.3389/ftox.2026.1751678

270 views

Case Report

Published on 04 Mar 2026

Co-occurring DMD, GJA1, and novel FYCO1 variants in a proband from a consanguineous oculodentodigital dysplasia family: a rare multi-locus case report

in Genetics of Common and Rare Diseases

Kondyarpu Abhishek
Nitish Kumar Mohanta
Joseph John
Swarupa Panda
Amit Kumar Satapathy
Roma Rattan
Puppala Venkat Ramchander

Frontiers in Genetics

doi 10.3389/fgene.2026.1753212

270 views

Systematic Review

Published on 04 Mar 2026

Efficacy and safety of neuromodulation and multimodal therapies for traumatic brain injury-induced disorders of consciousness: an updated umbrella review

in Neurorehabilitation

Xia Yang
Yongbiao Li
Nana Zhang
Dongwei Luo
Chunying Zhao
Qingshan Liu

Frontiers in Neurology

doi 10.3389/fneur.2026.1742096

107 views

Original Research

Published on 04 Mar 2026

A machine learning approach to identify optimal candidates for transarterial chemoembolization in unresectable HBV-related hepatocellular carcinoma complicated by first-branch portal vein tumor thrombus: a multicenter study

in Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers

Suo Zhao
Qi Zhang
Yumeng Tang
Yichong Wang
Jiawei Song
Tenghui Han
Huadong Zhao
Yuheng Zhang
Chunzhi Yuan
Xiuqin Li

Frontiers in Oncology

doi 10.3389/fonc.2026.1766607

Review

Published on 04 Mar 2026

Targeting magnesium homeostasis: a novel therapeutic strategy for liver diseases

in Nutritional Epidemiology

Lili Ji
Hanhan Yu
Ruwen Wang
Hongmei Yan
Xiaofeng Yin
Shanshan Guo
Ru Wang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1709477

Mini Review

Published on 04 Mar 2026

Potential impact of urolithin A on pathways relevant to sleep health: a mini review

in Nutritional Epidemiology

Ana Clara da C. Pinaffi-Langley
Faris M. Zuraikat
Marie-Pierre St-Onge
Andriy Yabluchanskiy

Frontiers in Nutrition

doi 10.3389/fnut.2026.1779855

Original Research

Published on 04 Mar 2026

Employment and financial experiences in millennial family caregivers

in Aging and Public Health

Megan C. Thomas Hebdon
Galilea Dupree
Janice Hernandez
Virginia Gallagher
Carolyn Phillips
Amy Patten
Neil Peterson
Michael Thomas

Frontiers in Public Health

doi 10.3389/fpubh.2026.1670668

140 views

Hypothesis and Theory

Published on 04 Mar 2026

Infection, vaccination and risk of dementia: a proposed immunological model

in Multiple Sclerosis and Neuroimmunology

Justin Devine
Bart Jacobs
Isabel Leroux-Roels
Geert Leroux-Roels
Robbert van der Most

Frontiers in Immunology

doi 10.3389/fimmu.2026.1748535

Original Research

Published on 04 Mar 2026

Correlation analysis of serum amyloid A, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammation index with neoadjuvant therapy efficacy and prognosis in breast cancer

in Breast Cancer

Yuanyuan Nong
Zhenzhen Zhou
Siyu Deng
Mengyu Liu
Xuefang Liang
Yonghua Jiang
Xinqing Ye
Aihua Tan

Frontiers in Oncology

doi 10.3389/fonc.2026.1695123

Case Report

Published on 04 Mar 2026

Case Report: Molecular diagnostics and clinical courses of two adult spinal pilocytic astrocytoma long-term survivors with GTF2I::BRAF fusion

in Neuro-Oncology and Neurosurgical Oncology

Lorenzo Argao
Pinar E. Zerk
Hsiang-Chih Lu
Zied Abdullaev
Martha Quezado
Michelle L. Cassidy
Bennett Mclver
Anna Choi
Marissa Panzer
Renee Tweneboah-Koduah

Frontiers in Oncology

doi 10.3389/fonc.2026.1670639

176 views

Editorial

Published on 04 Mar 2026

Editorial: Gene editing in cancer gene therapy

in Gene and Cell Therapy

Yuyue Hou
Yan Zhou
Keshan Wang
Xiaotian Xia

Frontiers in Medicine

doi 10.3389/fmed.2026.1797737

Case Report

Published on 04 Mar 2026

Case Report: Allogeneic hematopoietic stem cell transplantation in a patient with triple-allele expression at both HLA-B and HLA-C loci

in Alloimmunity and Transplantation

Yoshiyuki Fujita
Kyoko Yoshihara
Daisuke Takahashi
Hidenori Tanaka
Yusuke Kino
Fuyuki Yamagata
Mami Samori
Saki Takahashi
Satoshi Yoshihara

Frontiers in Immunology

doi 10.3389/fimmu.2026.1785227

102 views

Original Research

Published on 04 Mar 2026

Machine learning-based prediction of hernia risk in peritoneal dialysis patients: a comparative study of models and SHAP-driven interpretability analysis

in Nephrology

Yugang Cao
Xun Hu
Tao Fang
Jun Guo

Frontiers in Medicine

doi 10.3389/fmed.2026.1687055

Original Research

Published on 04 Mar 2026

Analysis of the current status and associated factors of career calling among novice nurses: a latent profile analysis

in Organizational Psychology

Dinuo Xin
Dina Xin
Ying Wang
Wenjuan Zhu
Wanling Li
Yuanwei Heng

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1651190

Original Research

Published on 04 Mar 2026

Investigations of the voltage-gated Ca++ channels and phosphodiesterase enzyme inhibitory-like potential explain the medicinal use of Otostegia fruticosa in diarrhea and hypermotile gut

in Gastrointestinal and Hepatic Pharmacology

Najeeb Ur Rehman
Mohd Nazam Ansari
Nasser Abdulaziz Alalaiwah
Eyad Omar Alotibi
Aman Karim
Tiegist Bahta
Khalil Y. Abujheisha
Muhammad Noman

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1790239

108 views

Articles

Integrative biology shows DPP4 affects inflammatory response to eclampsia and cell model growth via p65/NLRP3/ASC/Caspase-1 pathway

Protective effects of Lagerstroemia speciosa against paracetamol-induced renal and testicular toxicity in rats via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms

Co-occurring DMD, GJA1, and novel FYCO1 variants in a proband from a consanguineous oculodentodigital dysplasia family: a rare multi-locus case report

Efficacy and safety of neuromodulation and multimodal therapies for traumatic brain injury-induced disorders of consciousness: an updated umbrella review

A machine learning approach to identify optimal candidates for transarterial chemoembolization in unresectable HBV-related hepatocellular carcinoma complicated by first-branch portal vein tumor thrombus: a multicenter study

Targeting magnesium homeostasis: a novel therapeutic strategy for liver diseases

Potential impact of urolithin A on pathways relevant to sleep health: a mini review

Employment and financial experiences in millennial family caregivers

Infection, vaccination and risk of dementia: a proposed immunological model

Correlation analysis of serum amyloid A, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammation index with neoadjuvant therapy efficacy and prognosis in breast cancer

Case Report: Molecular diagnostics and clinical courses of two adult spinal pilocytic astrocytoma long-term survivors with GTF2I::BRAF fusion

Editorial: Gene editing in cancer gene therapy

Case Report: Allogeneic hematopoietic stem cell transplantation in a patient with triple-allele expression at both HLA-B and HLA-C loci

Machine learning-based prediction of hernia risk in peritoneal dialysis patients: a comparative study of models and SHAP-driven interpretability analysis

Analysis of the current status and associated factors of career calling among novice nurses: a latent profile analysis

Investigations of the voltage-gated Ca++ channels and phosphodiesterase enzyme inhibitory-like potential explain the medicinal use of Otostegia fruticosa in diarrhea and hypermotile gut