EDITORIAL article
Front. Med.
Sec. Gene and Cell Therapy
Gene Editing in Cancer Gene Therapy
Yuyue Hou 1
Yan Zhou 1
Keshan Wang 2
Xiaotian Xia 1
1. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2. Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Abstract
Gene editing technologies have rapidly evolved from experimental tools into promising therapeutic strategies in oncology. Advances in programmable nucleases, epigenome-targeting approaches, and delivery systems are reshaping how cancer is studied and treated. This Research Topic, Gene Editing in Cancer Gene Therapy, brings together five complementary contributions- Collectively, these five contributions portray gene editing in cancer therapy as an integrated continuum, from epigenetic regulation and immune modulation to delivery technologies, clinical genomics, and policy frameworks. Rather than focusing on a single technology, this Research Topic highlights the inherently interdisciplinary nature of gene editing and its expanding role in precision oncology.We hope that this Research Topic will serve as a valuable resource for researchers and clinicians seeking to understand the evolving landscape of gene editing in oncology, and that it will stimulate further interdisciplinary efforts bridging molecular engineering, cancer biology, and translational medicine.1.Zhang R, Yao T, Fan M, Jiang X, Wang K, Cui M, Bing K, Xia X. Precision scalpels for the epigenome: next-gen editing tools in targeted therapies. Front Med 2025; 12:1613722.
Summary
Keywords
cancer gene therapy, CAR-T cell therapy, CRISPR-Cas9-based tool, Delivery Systems, gene editing
Received
28 January 2026
Accepted
16 February 2026
Copyright
© 2026 Hou, Zhou, Wang and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xiaotian Xia
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.