Digital Spatial Profiling | List of Frontiers open access articles

Original Research

Published on 08 Apr 2022

Digital Spatial Profiling Reveals Functional Shift of Enterochromaffin Cell in Patients With Ulcerative Colitis

in Molecular and Cellular Pathology

Dongping Lyu
Guanjun Kou
Shiyang Li
Lixiang Li
Bing Li
Ruchen Zhou
Xiaoxiao Yang
Wenyu Tian
Yanqing Li
Xiuli Zuo

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.841090

8,829 views
6 citations

Original Research

Published on 02 Mar 2022

Digital Spatial Profiling of Individual Glomeruli From Patients With Anti-Neutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis

in Autoimmune and Autoinflammatory Disorders

Lin Ye
Yu Liu
Xuejing Zhu
Tongyue Duan
Chang Wang
Xiao Fu
Panai Song
Shuguang Yuan
Hong Liu
Lin Sun

Frontiers in Immunology

doi 10.3389/fimmu.2022.831253

9,908 views
19 citations

Original Research

Published on 19 Jan 2021

Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Patients

in Cancer Immunity and Immunotherapy

Arutha Kulasinghe
Touraj Taheri
Ken O’Byrne
Brett G. M. Hughes
Liz Kenny
Chamindie Punyadeera

Frontiers in Oncology

doi 10.3389/fonc.2020.607349

15,832 views
34 citations

Original Research

Published on 05 Jun 2025

Digital spatial profiling identifies phospho-JNK as a biomarker for early risk stratification of aggressive prostate cancer

in Molecular and Cellular Oncology

Samaneh Eickelschulte
Adam Kaczorowski
Florian Janke
Anja Lisa Riediger
Olga Lazareva
Sarah Böning
Glen Kristiansen
Constantin Schwab
Albrecht Stenzinger
Holger Sültmann

Frontiers in Oncology

doi 10.3389/fonc.2025.1572299

2,474 views
1 citation

Original Research

Published on 04 Mar 2024

Digital spatial profiling identifies molecular changes involved in development of colitis-associated colorectal cancer

in Gastrointestinal Cancers: Colorectal Cancer

Tamara Glyn
Sarah Williams
Martin Whitehead
Tim Eglinton
Nicholas West
Rachel V. Purcell

Frontiers in Oncology

doi 10.3389/fonc.2024.1247106

7,018 views
9 citations

Original Research

Published on 02 Feb 2026

Capturing the inflammatory landscape within kidney compartments of human diabetic kidney disease: a digital spatial profiling study

in Clinical Diabetes

Khaled M. Elhusseiny
Farha G. Deceus
Lynn D. Cornell
Xiaohui Bian
Yaohua Ma
Jennifer M. Kachergus
E. Aubrey Thompson
LaTonya J. Hickson

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1744430

502 views

Original Research

Published on 12 Sep 2024

Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status

in Head and Neck Cancer

Jill M. Brooks
Yuanning Zheng
Kelly Hunter
Benjamin E. Willcox
Janet Dunn
Paul Nankivell
Olivier Gevaert
Hisham Mehanna

Frontiers in Oncology

doi 10.3389/fonc.2024.1428741

3,721 views
4 citations

Original Research

Published on 25 Jul 2025

Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer

in Pharmacology of Anti-Cancer Drugs

Wenhao Wang
Wenhao Zhou
Jingli Fan
Tao Jiang
Guang Yang
Congcong Song
Siwei Xu
Haitao Luo
Huining Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567527

2,453 views
1 citation

Mini Review

Published on 11 Jul 2025

Multiplex imaging analysis of the tumor immune microenvironment for guiding precision immunotherapy

in Cancer Immunity and Immunotherapy

Feng Liu
Guiqing Li
Yi Zheng
Yanxia Liu
Kang Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617906

4,810 views
1 citation

Mini Review

Published on 25 Feb 2021

Single-Cell Profiling to Explore Immunological Heterogeneity of Tumor Microenvironment in Breast Cancer

in Cancer Immunity and Immunotherapy

Xiao Yuan
Jinxi Wang
Yixuan Huang
Dangang Shangguan
Peng Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2021.643692

27,168 views
51 citations

Original Research

Published on 20 Nov 2024

Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease

in Microbial Immunology

Timothy G. Wanninger
Omar A. Saldarriaga
Esteban Arroyave
Daniel E. Millian
Jason E. Comer
Slobodan Paessler
Heather L. Stevenson

Frontiers in Immunology

doi 10.3389/fimmu.2024.1439971

3,874 views
1 citation

Original Research

Published on 28 Jul 2022

An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling

in Cancer Immunity and Immunotherapy

Hao Yang
Julia Messina-Pacheco
Andrea Liliam Gomez Corredor
Alex Gregorieff
Jun-li Liu
Ali Nehme
Hamed S. Najafabadi
Yasser Riazalhosseini
Bo Gao
Zu-hua Gao

Frontiers in Immunology

doi 10.3389/fimmu.2022.961457

9,986 views
25 citations

Review

Published on 03 Jul 2024

Insights into brain tumor diagnosis: exploring in situ hybridization techniques

in Neurogenetics

E. D. Namiot
G. M. Zembatov
P. P. Tregub

Frontiers in Neurology

doi 10.3389/fneur.2024.1393572

5,613 views
1 citation

Original Research

Published on 15 Aug 2022

Spatial biology analysis reveals B cell follicles in secondary lymphoid structures may regulate anti-tumor responses at initial melanoma diagnosis

in B Cell Biology

Aaron D. Therien
Georgia M. Beasley
Kristen E. Rhodin
Norma E. Farrow
Douglas S. Tyler
David Boczkowski
Rami N. Al-Rohil
Eda K. Holl
Smita K. Nair

Frontiers in Immunology

doi 10.3389/fimmu.2022.952220

4,648 views
6 citations

Original Research

Published on 18 Aug 2025

Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer

in Breast Cancer

Hye Sung Won
Yong-Seok Kim
Kyung Jin Seo
Sun-Young Jun
Der Sheng Sun
Mihong Choi
Jung-Sook Yoon
Jae Ho Byun

Frontiers in Oncology

doi 10.3389/fonc.2025.1638758

3,386 views
1 citation

Original Research

Published on 20 Jun 2025

Overexpression of CTLA-4 and fibronectin, and lower expression of CD137 (4-1BB) is associated with brain metastasis of primary skin melanomas. An analysis of local immune response by digital spatial profiling

in Cancer Immunity and Immunotherapy

Shiva Najjary
Nur al Amery
Mengqi Huang
Disha Vadgama
Alexander C. J. van Akkooi
H. Jacobus Gilhuis
Zineb Belcaid
Dana Mustafa
Johan M. Kros

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578986

2,275 views

Articles

Digital Spatial Profiling Reveals Functional Shift of Enterochromaffin Cell in Patients With Ulcerative Colitis

Digital Spatial Profiling of Individual Glomeruli From Patients With Anti-Neutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis

Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Patients

Digital spatial profiling identifies phospho-JNK as a biomarker for early risk stratification of aggressive prostate cancer

Digital spatial profiling identifies molecular changes involved in development of colitis-associated colorectal cancer

Capturing the inflammatory landscape within kidney compartments of human diabetic kidney disease: a digital spatial profiling study

Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status

Spatial deciphering of the transcriptomic heterogeneity of tumor spread through air spaces in lung cancer

Multiplex imaging analysis of the tumor immune microenvironment for guiding precision immunotherapy

Single-Cell Profiling to Explore Immunological Heterogeneity of Tumor Microenvironment in Breast Cancer

Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease

An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling

Insights into brain tumor diagnosis: exploring in situ hybridization techniques

Spatial biology analysis reveals B cell follicles in secondary lymphoid structures may regulate anti-tumor responses at initial melanoma diagnosis

Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer

Overexpression of CTLA-4 and fibronectin, and lower expression of CD137 (4-1BB) is associated with brain metastasis of primary skin melanomas. An analysis of local immune response by digital spatial profiling