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5 articles related to "Dose Proportionality"

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Articles

Clinical Trial

Published on 21 Nov 2025

Clinical trial on the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Chinese males: an open-label, single and multiple dosage, parallel group study

in Translational Pharmacology

Hongzhong Liu
Tao Liu
Ming Liu
Xin Zheng
Wen Zhong
Qian Zhao
Ji Jiang
Pei Hu
Yishi Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713702

1,217 views

Original Research

Published on 12 Jun 2024

A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects

in Drug Metabolism and Transport

Mai Han
Bishan Huo
Gaoyun Hu
Xin Zhang
Gang Cui
Wei Wu
Na Mi
Shixi Zhang
Jiangli Jin
Xing Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1414066

2,517 views
2 citations

Clinical Trial

Published on 17 Aug 2023

Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants

in Ethnopharmacology

Phanit Songvut
Nuchanart Rangkadilok
Nanthanit Pholphana
Tawit Suriyo
Duangchit Panomvana
Porranee Puranajoti
Jaratluck Akanimanee
Jutamaad Satayavivad

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1230401

6,202 views
18 citations

Original Research

Published on 05 Aug 2022

Safety, tolerability, and pharmacokinetics/pharmacodynamics of JMT103 in patients with bone metastases from solid tumors

in Cancer Molecular Targets and Therapeutics

Xu Liang
Junli Xue
Xiaoxiao Ge
Jin Li
Huiping Li
Liqiong Xue
Lijun Di
Wenbo Tang
Guohong Song
Qun Li

Frontiers in Oncology

doi 10.3389/fonc.2022.971594

4,552 views
10 citations

Original Research

Published on 21 Jul 2020

Orally Administered Koumine Persists Longer in the Plasma of Aged Rats Than That of Adult Rats as Assessed by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

in Drug Metabolism and Transport

Li-Xiang Ye
Ying Xu
Shui-Hua Zhang
Da-Xuan Cao
Ling-Fan Chen
Yan-Ping Su
Hui-Hui Huang
Chang-Xi Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2020.01113

3,287 views
7 citations