Fast Inactivation | List of Frontiers open access articles

Original Research

Published on 06 Dec 2021

A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors

in Pharmacology of Ion Channels and Channelopathies

Shuijiao Peng
Minzhi Chen
Zhen Xiao
Xin Xiao
Sen Luo
Songping Liang
Xi Zhou
Zhonghua Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.778534

5,069 views
4 citations

Original Research

Published on 28 Feb 2022

The Pharmacological and Structural Basis of the AahII–NaV1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody

in Pharmacology of Ion Channels and Channelopathies

Riadh Hmaidi
Ayoub Ksouri
Rahma Benabderrazek
Viviane Antonietti
Pascal Sonnet
Mathieu Gautier
Balkiss Bouhaouala-Zahar
Halima Ouadid-Ahidouch

Frontiers in Pharmacology

doi 10.3389/fphar.2022.821181

3,724 views
2 citations

Original Research

Published on 23 Nov 2010

Phyla- and Subtype-Selectivity of CgNa, a Na+ Channel Toxin from the Venom of the Giant Caribbean Sea Anemone Condylactis Gigantea

in Pharmacology of Ion Channels and Channelopathies

Bert Billen
Sarah Debaveye
Lászlo Béress
Anoland Garateix
Jan Tytgat

Frontiers in Pharmacology

doi 10.3389/fphar.2010.00133

7,197 views
15 citations

Original Research

Published on 25 Jul 2025

Clinical, electromyographic, and biophysical characterization of the rare Nav1.4 channel mutation SCN4A L1436P

in Membrane Physiology and Membrane Biophysics

François Charles Wang
Olivier Bouquiaux
Isabelle Lievens
Bernard Lakaye
Laura Vandries
Margaux Poleur
Samira Abdou Ide
Nurcan Inci
Vincent Seutin

Frontiers in Physiology

doi 10.3389/fphys.2025.1617672

3,604 views

Original Research

Published on 28 Sep 2022

ARumenamides: A novel class of potential antiarrhythmic compounds

in Pharmacology of Ion Channels and Channelopathies

Mena Abdelsayed
Dana Page
Peter C. Ruben

Frontiers in Pharmacology

doi 10.3389/fphar.2022.976903

3,028 views
4 citations

Original Research

Published on 14 Oct 2021

Possible Interactions of Extracellular Loop IVP2-S6 With Voltage-Sensing Domain III in Cardiac Sodium Channel

in Pharmacology of Ion Channels and Channelopathies

Anastasia K. Zaytseva
Aleksandr S. Boitsov
Anna A. Kostareva
Boris S. Zhorov

Frontiers in Pharmacology

doi 10.3389/fphar.2021.742508

2,978 views
7 citations

Original Research

Published on 14 Jan 2022

The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation

in Neuropharmacology

Jennifer R. Deuis
Lotten Ragnarsson
Samuel D. Robinson
Zoltan Dekan
Lerena Chan
Ai-Hua Jin
Poanna Tran
Kirsten L. McMahon
Shengnan Li
John N. Wood

Frontiers in Pharmacology

doi 10.3389/fphar.2021.789570

5,174 views
10 citations

Original Research

Published on 02 Dec 2021

The L1624Q Variant in SCN1A Causes Familial Epilepsy Through a Mixed Gain and Loss of Channel Function

in Pharmacology of Ion Channels and Channelopathies

Laura B. Jones
Colin H. Peters
Richard E. Rosch
Maxine Owers
Elaine Hughes
Deb K. Pal
Peter C. Ruben

Frontiers in Pharmacology

doi 10.3389/fphar.2021.788192

4,677 views
6 citations

Review

Published on 28 Mar 2022

Sodium Channels and Local Anesthetics—Old Friends With New Perspectives

in Pharmacology of Ion Channels and Channelopathies

Jannis Körner
Simone Albani
Vishal Sudha Bhagavath Eswaran
Anna B. Roehl
Giulia Rossetti
Angelika Lampert

Frontiers in Pharmacology

doi 10.3389/fphar.2022.837088

20,295 views
53 citations

Original Research

Published on 29 Apr 2020

Sodium Channel Myotonia Due to Novel Mutations in Domain I of Nav1.4

in Neuromuscular Disorders and Peripheral Neuropathies

Serena Pagliarani
Sabrina Lucchiari
Marina Scarlato
Elisa Redaelli
Anna Modoni
Francesca Magri
Barbara Fossati
Stefano C. Previtali
Valeria A. Sansone
Marzia Lecchi

Frontiers in Neurology

doi 10.3389/fneur.2020.00255

6,154 views
6 citations

Original Research

Published on 22 Nov 2017

Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System

in Neuropharmacology

Xi Zhou
Zhen Xiao
Yan Xu
Yunxiao Zhang
Dongfang Tang
Xinzhou Wu
Cheng Tang
Minzhi Chen
Xiaoliu Shi
Ping Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2017.00852

9,326 views
43 citations

Original Research

Published on 16 Oct 2018

Discovery of a Novel Nav1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy

in Pharmacology of Ion Channels and Channelopathies

Yunxiao Zhang
Dezheng Peng
Biao Huang
Qiuchu Yang
Qingfeng Zhang
Minzhi Chen
Mingqiang Rong
Zhonghua Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01158

5,941 views
19 citations

Original Research

Published on 19 Jun 2015

MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels

in Pharmacology of Ion Channels and Channelopathies

Michael E. O’Leary
Mohamed Chahine

Frontiers in Pharmacology

doi 10.3389/fphar.2015.00118

4,360 views
4 citations

Original Research

Published on 19 Feb 2026

Characterization of the R893C NaV1.5 mutation in Brugada syndrome

in Cardiovascular Genetics and Systems Medicine

Szabolcs Gaal
Beata Meszaros
Julianna Volko
Noemi Bilakovics
Muhammad Umair Naseem
Zoltán Pethő
Gabor Sandorfi
Gabor Menko
Orsolya Voros
Istvan Balogh

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1726536

343 views

Original Research

Published on 16 Jun 2023

The volatile anesthetic isoflurane differentially inhibits voltage-gated sodium channel currents between pyramidal and parvalbumin neurons in the prefrontal cortex

Jingxuan Qiu
Yaoxin Yang
Jin Liu
Wenling Zhao
Qian Li
Tao Zhu
Peng Liang
Cheng Zhou

Frontiers in Neural Circuits

doi 10.3389/fncir.2023.1185095

5,959 views
13 citations

Original Research

Published on 22 Dec 2020

Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death

in Cardiac Electrophysiology

Mohammad-Reza Ghovanloo
Joseph Atallah
Carolina A. Escudero
Peter C. Ruben

Frontiers in Physiology

doi 10.3389/fphys.2020.610436

4,468 views
14 citations

Articles

A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors

The Pharmacological and Structural Basis of the AahII–NaV1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody

Phyla- and Subtype-Selectivity of CgNa, a Na+ Channel Toxin from the Venom of the Giant Caribbean Sea Anemone Condylactis Gigantea

Clinical, electromyographic, and biophysical characterization of the rare Nav1.4 channel mutation SCN4A L1436P

ARumenamides: A novel class of potential antiarrhythmic compounds

Possible Interactions of Extracellular Loop IVP2-S6 With Voltage-Sensing Domain III in Cardiac Sodium Channel

The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation

The L1624Q Variant in SCN1A Causes Familial Epilepsy Through a Mixed Gain and Loss of Channel Function

Sodium Channels and Local Anesthetics—Old Friends With New Perspectives

Sodium Channel Myotonia Due to Novel Mutations in Domain I of Nav1.4

Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System

Discovery of a Novel Nav1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy

MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels

Characterization of the R893C NaV1.5 mutation in Brugada syndrome

The volatile anesthetic isoflurane differentially inhibits voltage-gated sodium channel currents between pyramidal and parvalbumin neurons in the prefrontal cortex

Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death