Hard Problems | List of Frontiers open access articles

Original Research

Published on 04 Mar 2026

Predictive value of OGTT parameters and clinical markers in gestational diabetes mellitus: a prospective randomized controlled trial from a tertiary center in Türkiye

in Developmental Endocrinology

Batuhan Turgay
Uğurcan Zorlu
Harun Kılıçkıran
Kayra Turgay
Gülşah Aynaoğlu Yıldız
Elif Gül Yapar Eyi
A. Seval Ozgu-Erdinc

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1793806

Original Research

Published on 04 Mar 2026

Network-enhanced machine learning framework for multi crop yield prediction: a comprehensive analysis of indian agricultural data

in Agroecological Cropping Systems

Shinyclimensa C
Parthiban A

Frontiers in Agronomy

doi 10.3389/fagro.2026.1767878

404 views

Original Research

Published on 04 Mar 2026

Comprehensive evaluation of environment adaptability in wild and captive lenok (Brachymystax lenok): from the perspective of antioxidant capacity, immune response and gut microbiome

in Microbial Symbioses

Luye Bai
Ziyang Wang
Hongxing Wang
Bo Ma

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1764670

101 views

Curriculum, Instruction, and Pedagogy

Published on 04 Mar 2026

Measuring teacher formative assessment literacy in primary education: a multidimensional study using the T-FALS scale

in Teacher Education

Blerina Çibukçiu
Donika Koliqi

Frontiers in Education

doi 10.3389/feduc.2026.1787953

Review

Published on 04 Mar 2026

Drivers and potential effects of endocrine disruption in wild mammals: known facts and open questions

in Toxicology, Pollution and the Environment

Mina Cansu Karaer
Tomaž Snoj

Frontiers in Environmental Science

doi 10.3389/fenvs.2026.1761496

116 views

Original Research

Published on 04 Mar 2026

How gentle power enables community-based conservation: hydrosocial practices and institutional support in Tokyo’s satoyama

in Water and Human Systems

Mikiko Sugiura

Frontiers in Water

doi 10.3389/frwa.2026.1759412

Original Research

Published on 04 Mar 2026

Teaching effectiveness in agricultural higher education: insights from PCA-based indexing and AHP constraint prioritization

in Assessment, Testing and Applied Measurement

Sreenanda S. Anand
Girijesh Singh Mahra
Rabindra Nath Padaria
Sitaram Bishnoi
Mrinmoy Ray
Satyapriya
Subhashree Sahu
Pratibha Joshi
Misha M. Madhavan
B. M. Yogesh

Frontiers in Education

doi 10.3389/feduc.2026.1761188

Brief Research Report

Published on 04 Mar 2026

Ictal fear of death with preserved context dependent speech and postictal amnesia in focal epilepsy

in Epilepsy

Christopher Saouda
Yasmeen Kassem-Scott
Elham El Hallak
Prarthana Hareesh
Victoria Vinarsky
Alexandra Eid
Yamane Makke
Mohamad Zakaria Koubeissi

Frontiers in Neurology

doi 10.3389/fneur.2026.1784636

Original Research

Published on 04 Mar 2026

Diagnostic odyssey of patients with the rare immunodeficiency activated PI3 kinase delta syndrome (APDS): case study from expert and patient surveys

in Primary Immunodeficiencies

Hermann Maximilian Wolf
Fabio Candotti
Roman Spelsberg
Georgios Sogkas
Hans-Holger Bleß
Kirsten H. Herrmann
Fabian Hauck

Frontiers in Immunology

doi 10.3389/fimmu.2026.1763482

141 views

Systematic Review

Published on 04 Mar 2026

Efficacy and safety of immune checkpoint inhibitors combined with chemoradiotherapy in locally advanced cervical cancer: a systematic review and meta-analysis

in Pharmacology of Anti-Cancer Drugs

Chao Xiao
Siyuan Zeng
Luying Li
Ruiqi Wang
Xue Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1766157

178 views

Review

Published on 04 Mar 2026

Rhythms of life: melatonin, nutrition, sleep, and antioxidant strategies for healthy aging

in Sleep and Circadian Rhythms

Cristina Manuela Drăgoi
Ion-Bogdan Dumitrescu
Alina Crenguţa Nicolae

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1736978

289 views

Policy and Practice Reviews

Published on 04 Mar 2026

Bioremediation of CVOC contamination in the subsurface of Utrecht, the Netherlands, and its interaction with Aquifer Thermal Energy Storage to protect drinking water sources

in Water and Built Environment

Niels van Ras
Maurice Henssen
Tim Grotenhuis

Frontiers in Water

doi 10.3389/frwa.2026.1771734

163 views

Original Research

Published on 04 Mar 2026

Ameliorative effects of desert truffle Terfezia claveryi extract on Hysterothylacium thalassini- induced oxidative damage in C57BL/6 mice

in Parasite and Host

Mashael Alotaibi
Saleh Al Quraishy
Nada Almohawis
Simeon Santourlidis
Esam Al-Shaebi
Rewaida Abdel-Gaber

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2026.1774323

125 views

Original Research

Published on 04 Mar 2026

Integrated disease management components for Fusarium wilt of banana in India: Effects of organic amendments, flooding, and paddy rotation on disease severity

in Disease Management

Raman Thangavelu
Murugan Loganathan
Perumal Ganga Devi
Boopathy Nithya
Altus Viljoen
Guy Blomme
Thangaraj Sekar
Ramasamy Selvarajan

Frontiers in Agronomy

doi 10.3389/fagro.2026.1749035

314 views

Correction

Published on 04 Mar 2026

Correction: RPL28 mediates sorafenib resistance in hepatocellular carcinoma by downregulating CDC6 expression

in Cancer Molecular Targets and Therapeutics

Yi Shi
Fangfang Chen
Yuanyuan Weng
Hang Zeng
Gang Chen

Frontiers in Oncology

doi 10.3389/fonc.2026.1814738

Original Research

Published on 04 Mar 2026

Anticoagulant-free preparation of autologous platelet-rich plasma (PRP) / fluid platelet-rich fibrin (f-PRF): a pre-clinical comparative performance study

in Integrative and Regenerative Pharmacology

Alice Assinger
Anita Pirabe
Jonas Santol
Abbas Muhammad
David Kuroki-Hasenöhrl

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1785884

Articles

Predictive value of OGTT parameters and clinical markers in gestational diabetes mellitus: a prospective randomized controlled trial from a tertiary center in Türkiye

Network-enhanced machine learning framework for multi crop yield prediction: a comprehensive analysis of indian agricultural data

Comprehensive evaluation of environment adaptability in wild and captive lenok (Brachymystax lenok): from the perspective of antioxidant capacity, immune response and gut microbiome

Measuring teacher formative assessment literacy in primary education: a multidimensional study using the T-FALS scale

Drivers and potential effects of endocrine disruption in wild mammals: known facts and open questions

How gentle power enables community-based conservation: hydrosocial practices and institutional support in Tokyo’s satoyama

Teaching effectiveness in agricultural higher education: insights from PCA-based indexing and AHP constraint prioritization

Ictal fear of death with preserved context dependent speech and postictal amnesia in focal epilepsy

Diagnostic odyssey of patients with the rare immunodeficiency activated PI3 kinase delta syndrome (APDS): case study from expert and patient surveys

Efficacy and safety of immune checkpoint inhibitors combined with chemoradiotherapy in locally advanced cervical cancer: a systematic review and meta-analysis

Rhythms of life: melatonin, nutrition, sleep, and antioxidant strategies for healthy aging

Bioremediation of CVOC contamination in the subsurface of Utrecht, the Netherlands, and its interaction with Aquifer Thermal Energy Storage to protect drinking water sources

Ameliorative effects of desert truffle Terfezia claveryi extract on Hysterothylacium thalassini- induced oxidative damage in C57BL/6 mice

Integrated disease management components for Fusarium wilt of banana in India: Effects of organic amendments, flooding, and paddy rotation on disease severity

Correction: RPL28 mediates sorafenib resistance in hepatocellular carcinoma by downregulating CDC6 expression

Anticoagulant-free preparation of autologous platelet-rich plasma (PRP) / fluid platelet-rich fibrin (f-PRF): a pre-clinical comparative performance study