Hard Problems | List of Frontiers open access articles

Original Research

Published on 14 May 2026

Risk factors for pneumonia, hepatic encephalopathy, and acute kidney injury in patients with hepatitis B virus–related acute-on-chronic liver failure

in Hepatobiliary Diseases

Li Wei
Wenjuan Shi
Xuefang Yang
Haiwen Ma
Hong Wan
Xiaoli Zhou

Frontiers in Medicine

doi 10.3389/fmed.2026.1804550

148 views

Opinion

Published on 14 May 2026

Circular economy to circular societies: universities as mindset infrastructures for transformative change

in Circular Economy

Sarfraz Aslam
Sharareh Shahidi Hamedani
Shervin Shahidi Hamedani

Frontiers in Sustainability

doi 10.3389/frsus.2026.1780982

247 views

Original Research

Published on 14 May 2026

Morphological characteristics of lumbar vertebral bodies and regional distribution patterns of bone mineral density: a CT study

in Skeletal Physiology

Xiaoteng Li
Fengzi Lv
Xin Tang
Peng Jia
Yang Gao

Frontiers in Physiology

doi 10.3389/fphys.2026.1820186

174 views

Original Research

Published on 14 May 2026

Dynamic changes and clinical significance of the gut microbiota and serum metabolites in breast cancer onset, progression and chemotherapy intervention

in Breast Cancer

Shuyun Jiang
Zhanwei Du
Yufei Wang
Hongwei Ma
Zhijun Ma
Xiaowang Wang

Frontiers in Oncology

doi 10.3389/fonc.2026.1795317

173 views

Original Research

Published on 14 May 2026

Design principles for PTG-oriented VR mindfulness in cancer survivorship: a qualitative-to-prototype translation framework

in Virtual Reality in Medicine

Jos Gijbels

Frontiers in Virtual Reality

doi 10.3389/frvir.2026.1822439

278 views

Original Research

Published on 14 May 2026

Semantic convergence in culturally loaded text translation by Large Language Models: a cross-model empirical analysis of English translations of The Four Books

in Cognitive Science

Qizheng Wan
Qiangfu Yu

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1829488

232 views

Original Research

Published on 14 May 2026

Middle-aged predominance and diagnostic delays in anti-LGI1 encephalitis: the role of antibody testing

in Multiple Sclerosis and Neuroimmunology

Shu Kan
Gege Zhang
Hua Yu
Hongmei Ding

Frontiers in Neurology

doi 10.3389/fneur.2026.1777478

743 views

Original Research

Published on 14 May 2026

Heterogeneous trajectories of nutritional support needs in patient–caregiver dyads following radical esophagectomy: a latent class growth analysis

in Clinical Nutrition

Wei Guo
Jing Cui
Yiqian Ni
Yanhua Li
Bowen Shi
Xue Liu
Wenqian Qi
Yi Zhang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1789423

254 views

Original Research

Published on 14 May 2026

Dynamics of combustibility and chemical composition of litter in Platycladus orientalis stands

in Fire and Forests

Jiacheng Zhang
Xingjian Dun
Wei Cheng
Wentai Zhao
Yusong Hou
Jiangbao Xia
Shimei Li

Frontiers in Forests and Global Change

doi 10.3389/ffgc.2026.1811525

213 views

Original Research

Published on 14 May 2026

Construction of an Interpretive Structural Model-Analytic Network Process model for preschool children’s drowning risk factors based on the Haddon matrix

in Injury Prevention and Control

Feifei Ma
Dongmei Luo
Hongqiang Liu
Guohui Zhao

Frontiers in Public Health

doi 10.3389/fpubh.2026.1819414

223 views

Original Research

Published on 14 May 2026

Association of quality of speech perception with quality of life in cochlear implant users with single sided deafness

in Otology and Neurotology

Nandita V. Vegesna
Isaac L. Alter
Scott Kelly
Meghan A. Despotidis
Megan E. Kuhlmey
Rhea N. Shah
Ramzi K. Elased
Jordan A. Rubenstein
Tiffany P. Hwa
Anil K. Lalwani

Frontiers in Audiology and Otology

doi 10.3389/fauot.2026.1740450

282 views

Original Research

Published on 14 May 2026

Gender, technology, and labor in small-scale aquaculture in Chile

in Marine Affairs and Policy

Constantino Villarroel
Katina Roumbedakis
Julia T. Verba
Angelo Araya-Piñones
Gillian B. Ainsworth
Valeria Burgos-Fuster
Nancy Chandía
Niris Cortes
Andrés Hurtado
Veronica Relano

Frontiers in Marine Science

doi 10.3389/fmars.2026.1771071

397 views

Review

Published on 14 May 2026

Advancing rehabilitation in Parkinson’s disease through virtual reality: a narrative review

in Neurorehabilitation

Pierluigi Diotaiuti
Francesco Di Siena
Marco Palombo
Giulio Marotta
Elisa Cavicchiolo
Pio Alfredo Di Tore
Stefania Mancone

Frontiers in Neurology

doi 10.3389/fneur.2026.1761459

316 views

Original Research

Published on 14 May 2026

The effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial

in Clinical Nutrition

Gustavo Henrique Ferreira Gonçalinho
Verônica Coelho
Sandra Maria Monteiro
Célia Maria Cassaro Strunz
Jorge Kalil
Antonio de Padua Mansur

Frontiers in Nutrition

doi 10.3389/fnut.2026.1814668

344 views

Original Research

Published on 14 May 2026

Pulvinar pathways as skip connections in deep neural networks for vision

in Perception and Attention Neuroimaging

Narmin Zarinabadi
Christian Casanova
Nelson Cortes

Frontiers in Neuroimaging

doi 10.3389/fnimg.2026.1800369

131 views

Original Research

Published on 14 May 2026

MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma

in Molecular Innate Immunity

Xiuqin An
Yanfang Gao
Shangyumeng Zhao
Wei He
Xinda Yang
Yujie Wu
Jihao Li
Runxi Yi
Yue Han
Mingxuan Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1849407

196 views

Articles

Risk factors for pneumonia, hepatic encephalopathy, and acute kidney injury in patients with hepatitis B virus–related acute-on-chronic liver failure

Circular economy to circular societies: universities as mindset infrastructures for transformative change

Morphological characteristics of lumbar vertebral bodies and regional distribution patterns of bone mineral density: a CT study

Dynamic changes and clinical significance of the gut microbiota and serum metabolites in breast cancer onset, progression and chemotherapy intervention

Design principles for PTG-oriented VR mindfulness in cancer survivorship: a qualitative-to-prototype translation framework

Semantic convergence in culturally loaded text translation by Large Language Models: a cross-model empirical analysis of English translations of The Four Books

Middle-aged predominance and diagnostic delays in anti-LGI1 encephalitis: the role of antibody testing

Heterogeneous trajectories of nutritional support needs in patient–caregiver dyads following radical esophagectomy: a latent class growth analysis

Dynamics of combustibility and chemical composition of litter in Platycladus orientalis stands

Construction of an Interpretive Structural Model-Analytic Network Process model for preschool children’s drowning risk factors based on the Haddon matrix

Association of quality of speech perception with quality of life in cochlear implant users with single sided deafness

Gender, technology, and labor in small-scale aquaculture in Chile

Advancing rehabilitation in Parkinson’s disease through virtual reality: a narrative review

The effects of resveratrol on endothelial progenitor cells and apoptosis biomarkers in postmenopausal women with chronic coronary heart disease: a randomized controlled trial

Pulvinar pathways as skip connections in deep neural networks for vision

MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma