Hard Problems | List of Frontiers open access articles

Original Research

Published on 06 Mar 2026

Qualitative content analysis of reactivity effects and feasibility of ecological momentary assessments of suicide-related thoughts and behaviors in the long-term and in suicidal crises

in Digital Mental Health

Lena Spangenberg
Cora Spahn
Jana Serebriakova
Thomas Forkmann
Heide Glaesmer

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1744947

Mini Review

Published on 06 Mar 2026

A dialectical lens for AI and medical humanities: advancing responsible augmented humanism in Digital Public Health

in Digital Public Health

Sifan Chen
Zining Peng
Nian Liu

Frontiers in Public Health

doi 10.3389/fpubh.2026.1771351

Original Research

Published on 06 Mar 2026

Towards natural stand-up movement support: guiding higher-dimensional muscle activation using a Lower-DOF assistive chair

in Biomechanics

Takahide Ito
Jun Morimoto
Qi An
Yuichi Nakamura
Jun-ichiro Furukawa

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1771282

Perspective

Published on 06 Mar 2026

Productive chaos and precision engineering: decoupling discovery from manufacturing to revolutionize plant-inspired therapeutics

in Plant Metabolism and Chemodiversity

Dexter Achu Mosoh

Frontiers in Plant Science

doi 10.3389/fpls.2026.1771802

277 views

Original Research

Published on 06 Mar 2026

Exploring the influence of AI self-study rooms on K–12 learners’ motivation, self-regulation, enjoyment, and engagement

in Educational Psychology

Wei Li
Ya Xu
Le Yao
Yantong Liu

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1768389

479 views

Original Research

Published on 06 Mar 2026

Decision-making for pediatric vaccination scheduling under multiple constraints: a case study from China✰

in Public Health Policy

Xiaochen Ma
Qiang Huang
Shanshan Chai
Mingxia Zhang

Frontiers in Public Health

doi 10.3389/fpubh.2026.1768367

115 views

Original Research

Published on 06 Mar 2026

ChatGPT-4o with faculty guidance outperforms AI-only and traditional learning in ultrasonography training: a randomized trial

in Connected Health

Dao-Rong Hong
Chun-Yan Huang
Jiu Gao

Frontiers in Digital Health

doi 10.3389/fdgth.2026.1772965

204 views

Case Report

Published on 06 Mar 2026

Undifferentiated embryonal sarcoma of the liver in an 11-year-old boy: a case report and clinical insights

in Surgical Oncology

Zhiru Liang
Weihong Chen
Weihong Duan
Chaoyue Song
Jianjia Xiao
Delei Yu
Yu Xie

Frontiers in Surgery

doi 10.3389/fsurg.2026.1772085

Original Research

Published on 06 Mar 2026

Acute effect of citrulline malate on flow-mediated dilation and serum pharmacodynamics in healthy young males

in Vascular Physiology

Johan Grannes
Nigel A. Callender
Adam M. Gonzalez
Jonny Hisdal
Fredrik T. Vårvik
Thomas Bjørnsen

Frontiers in Physiology

doi 10.3389/fphys.2026.1773582

349 views

Systematic Review

Published on 06 Mar 2026

Osteocytes orchestrate browning: emerging signals in bone-fat crosstalk: a systematic review

in Bone Research

Houmam Anees
Vahid Jahed
Zahra Sabouri
Reem Jamous
Cristian Pablo Pennisi
Christian Heiss
Thaqif El Khassawna

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1766959

220 views

Original Research

Published on 06 Mar 2026

A network pharmacology–guided multi-omics and spatial single-cell framework nominates WT1 as a spironolactone-linked immune biomarker in prostate cancer

in Pharmacology of Anti-Cancer Drugs

Zhen Zhu
Xingjun He

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1770261

206 views

Original Research

Published on 06 Mar 2026

Development and efficacy evaluation of a competency-based training program for pediatric operating room nurses

in Healthcare Professions Education

Qingqing Du
Zhen Wang
Mengfan Xia
Jing Cao
Yingmin Liu
Ziwei Jin
Xia Yang

Frontiers in Medicine

doi 10.3389/fmed.2026.1769565

201 views

Original Research

Published on 06 Mar 2026

Effects of different supplemental calcium propionate levels on corn stover silage fermentation quality and bacterial community diversity, and their impacts on growth performance, metabolism, and blood biochemical indices of Hu lambs

in Animal Nutrition

Weiyang Zhang
Quanchao Gao
Hui Chen
Junyu Zhang
Yang Yue
Renping Liu
Guodong Zhao
Kailun Yang

Frontiers in Animal Science

doi 10.3389/fanim.2026.1775038

Original Research

Published on 06 Mar 2026

Integrated metabolomic, proteomic, and transcriptomic analyses reveal the production of bioactive metabolites and antidiabetic effects in mature Solanum lasiocarpum fruit

in Plant Bioinformatics

Fangbo Li
Zixiao Jiang
Arunrat Chaveerach
Frédéric Anderson Konkobo
Mohd Kafeel Ahmad Ansari
Gwendolyn Felocity Ban
Mamadou Abdoulaye Konare
Lamin Manjang
Zachary Rochelin
Yang Yang

Frontiers in Plant Science

doi 10.3389/fpls.2026.1774981

252 views

Case Report

Published on 06 Mar 2026

Next generation sequencing guided treatment of ALK tyrosine kinase inhibitor induced long survival in lung squamous cell carcinoma harboring ROS1 gene fusions: a case report and literature review

in Precision Medicine

Mei Liu
Fenge Li
Ning Mu
Ning Kang
Shengnan Wu
Yue Xu
Xinyi Wang
Huan Lü
Chunhua Ma

Frontiers in Medicine

doi 10.3389/fmed.2026.1771353

118 views

Original Research

Published on 06 Mar 2026

Sperm whale hotspots off western Ireland and the importance of dynamic variables as shown by a multiscale Bayesian additive regression trees workflow

in Marine Megafauna

Cynthia Barile
Simon Berrow
Jonathan Gordon
Rossa Meade
Morgane Pommier
Joanne O’Brien

Frontiers in Marine Science

doi 10.3389/fmars.2026.1767540

309 views

Articles

Qualitative content analysis of reactivity effects and feasibility of ecological momentary assessments of suicide-related thoughts and behaviors in the long-term and in suicidal crises

A dialectical lens for AI and medical humanities: advancing responsible augmented humanism in Digital Public Health

Towards natural stand-up movement support: guiding higher-dimensional muscle activation using a Lower-DOF assistive chair

Productive chaos and precision engineering: decoupling discovery from manufacturing to revolutionize plant-inspired therapeutics

Exploring the influence of AI self-study rooms on K–12 learners’ motivation, self-regulation, enjoyment, and engagement

Decision-making for pediatric vaccination scheduling under multiple constraints: a case study from China✰

ChatGPT-4o with faculty guidance outperforms AI-only and traditional learning in ultrasonography training: a randomized trial

Undifferentiated embryonal sarcoma of the liver in an 11-year-old boy: a case report and clinical insights

Acute effect of citrulline malate on flow-mediated dilation and serum pharmacodynamics in healthy young males

Osteocytes orchestrate browning: emerging signals in bone-fat crosstalk: a systematic review

A network pharmacology–guided multi-omics and spatial single-cell framework nominates WT1 as a spironolactone-linked immune biomarker in prostate cancer

Development and efficacy evaluation of a competency-based training program for pediatric operating room nurses

Effects of different supplemental calcium propionate levels on corn stover silage fermentation quality and bacterial community diversity, and their impacts on growth performance, metabolism, and blood biochemical indices of Hu lambs

Integrated metabolomic, proteomic, and transcriptomic analyses reveal the production of bioactive metabolites and antidiabetic effects in mature Solanum lasiocarpum fruit

Next generation sequencing guided treatment of ALK tyrosine kinase inhibitor induced long survival in lung squamous cell carcinoma harboring ROS1 gene fusions: a case report and literature review

Sperm whale hotspots off western Ireland and the importance of dynamic variables as shown by a multiscale Bayesian additive regression trees workflow