Harsh Climatic Conditions | List of Frontiers open access articles

Original Research

Published on 10 Nov 2025

Radiomics reveals the biological basis for non-small cell lung cancer prognostic stratification by reflecting tumor immune microenvironment heterogeneity

in Cancer Immunity and Immunotherapy

Qing Huang
Nie Xu
Jun Yin
Peng Diao
Tianpeng Xie
Ke Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708692

209 views

Original Research

Published on 10 Nov 2025

Tibetan medicine Pa Zhu Wan ameliorates carbon tetrachloride-induced liver fibrosis in rats by regulating the TGF-β-Smad2/3 and IL-6/JAK2/STAT3 signaling pathways

in Ethnopharmacology

Linlin Zhao
Yan Jiang
Jing Ma
Yongjing Yang
Guo Liu
Zhengxing Wang
Tin Wui Wong
Dejun Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667685

188 views

Review

Published on 10 Nov 2025

A meta-synthesis of qualitative studies on cardiovascular disease patients’ experiences using digital health tools

in Digital Public Health

Yuxuan Shao
Xinyi Hou
Qin Peng
Mengdie Hu
Chaofeng Li

Frontiers in Public Health

doi 10.3389/fpubh.2025.1709562

152 views

Review

Published on 10 Nov 2025

Application of matrix-assisted laser desorption/ionization time-of flight mass spectrometry in clinical testing and diagnosis

in Clinical and Diagnostic Microbiology and Immunology

Qiushuang Xiong
Haotong Guan

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1607258

310 views

Original Research

Published on 10 Nov 2025

Modulation of TNFα-driven neuroinflammation by Gardenin A: insights from in vitro, in vivo, and in silico studies

in Inflammation Pharmacology

Prashsti Chadha
Hiral Aghara
Harshrajsinh Solanki
Manali Patel
Dhrubjyoti Sharma
Vijay Thiruvenkatam
Palash Mandal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681403

463 views

Original Research

Published on 10 Nov 2025

Age-dependent diminution of female prognostic advantage in gastrointestinal stromal tumors: a retrospective cohort analysis

in Cancer Immunity and Immunotherapy

Yue Zhang
Qi Liu
Bing Ma
Hao Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617019

107 views

Community Case Study

Published on 10 Nov 2025

Optimizing resources in genomic surveillance: South Carolina’s QC-plus approach

in Infectious Diseases: Epidemiology and Prevention

Rachel Cox
Gregory Goodwin
Jessica Freeman
Gabrielle Godfrey
Anyway Kapingidza
Andrew Smith
Julia Scott
Abdoulaye Diedhiou
Karla Buru
Cory J. Weaver

Frontiers in Public Health

doi 10.3389/fpubh.2025.1694911

198 views

Mini Review

Published on 10 Nov 2025

Application of artificial intelligence in eosinophilic esophagitis

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Xiaoming Xu
Hualei Chen
Yun Chen
Lijuan Fan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712113

214 views

Original Research

Published on 10 Nov 2025

Educational leadership under construction: an experimental study on emotions and task performance using LEGO® bricks

in Leadership in Education

Mercedes Ventura
Noelia Ventura-Campos

Frontiers in Education

doi 10.3389/feduc.2025.1660135

178 views

Original Research

Published on 10 Nov 2025

Combined transcriptomic and metabolomic analysis of phenylpropanoid biosynthesis in the mechanism of leaf angle formation in Sorghum

in Plant Breeding

Jinhong Li
Yiwei Wang
Yuche Zhao
Yanpeng Zhang
Kuangzheng Qu
Zhenxing Zhu
Chunyu Wang
Zhenjun Li
Ling Cong
Shuang Gang

Frontiers in Plant Science

doi 10.3389/fpls.2025.1665475

296 views

Review

Published on 10 Nov 2025

The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease

in Neuroplasticity and Development

Nina Khera
Ravikiran M. Raju
Stuart A. Lipton

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1665802

244 views

Case Report

Published on 10 Nov 2025

Case Report: Overcoming calcified nodules by repeated aggressive debulking and stent-free percunatenous coronary intervention using a drug-coated balloon

in Coronary Artery Disease

Atsushi Funatsu
Kenshi Ono
Ryotaro Tani
Hideki Maeda
Masahiro Mizobuchi
Satoshi Akabame
Tomoko Kobayashi
Norihito Nakamura
Sho Torii
Gaku Nakazawa

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1674711

175 views

Editorial

Published on 10 Nov 2025

Editorial: New approaches to overcome the blood-brain barrier for the treatment of CNS disorders

in Non-Neuronal Cells

Mikko Gynther
Gert Fricker
Sabrina Petralla

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1730250

358 views

Original Research

Published on 10 Nov 2025

Impact of continuity of care under the model of healthcare integration on treatment outcomes and prognostic recovery of orthodontic patients

in Family Medicine and Primary Care

Qing Li
Ruihan Wu
Chen Du
Qifeng Miao

Frontiers in Medicine

doi 10.3389/fmed.2025.1632725

156 views

Original Research

Published on 10 Nov 2025

Effects of variable-intensity interval training and moderate-intensity continuous aerobic exercise on executive function and underlying neural mechanisms in male college students

in Movement Science

Haoqin Si
Chen Yan
Tong Zhu
Mengqi Liu
Ziyang Yang
Niyuan Hu
Ying Qin
Liang Mu

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1643698

201 views

Original Research

Published on 10 Nov 2025

Short-term results of curcumin, quercetin, hyaluronic acid and chondroitin sulfate (Ialuril Soft Gels®) in the management of chronic prostatitis/primary prostate pain syndrome: a single-center prospective study

in Genitourinary Surgery and Interventions

Valerio Iacovelli
Matteo Vittori
Marco Carilli
Chiara Cipriani
Marta Signoretti
Michele Antonucci
Filomena Petta
Beatrice Filippi
Giulia Di Giovanni
Francesco Maiorino

Frontiers in Surgery

doi 10.3389/fsurg.2025.1700681

468 views

Articles

Radiomics reveals the biological basis for non-small cell lung cancer prognostic stratification by reflecting tumor immune microenvironment heterogeneity

Tibetan medicine Pa Zhu Wan ameliorates carbon tetrachloride-induced liver fibrosis in rats by regulating the TGF-β-Smad2/3 and IL-6/JAK2/STAT3 signaling pathways

A meta-synthesis of qualitative studies on cardiovascular disease patients’ experiences using digital health tools

Application of matrix-assisted laser desorption/ionization time-of flight mass spectrometry in clinical testing and diagnosis

Modulation of TNFα-driven neuroinflammation by Gardenin A: insights from in vitro, in vivo, and in silico studies

Age-dependent diminution of female prognostic advantage in gastrointestinal stromal tumors: a retrospective cohort analysis

Optimizing resources in genomic surveillance: South Carolina’s QC-plus approach

Application of artificial intelligence in eosinophilic esophagitis

Educational leadership under construction: an experimental study on emotions and task performance using LEGO® bricks

Combined transcriptomic and metabolomic analysis of phenylpropanoid biosynthesis in the mechanism of leaf angle formation in Sorghum

The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease

Case Report: Overcoming calcified nodules by repeated aggressive debulking and stent-free percunatenous coronary intervention using a drug-coated balloon

Editorial: New approaches to overcome the blood-brain barrier for the treatment of CNS disorders

Impact of continuity of care under the model of healthcare integration on treatment outcomes and prognostic recovery of orthodontic patients

Effects of variable-intensity interval training and moderate-intensity continuous aerobic exercise on executive function and underlying neural mechanisms in male college students

Short-term results of curcumin, quercetin, hyaluronic acid and chondroitin sulfate (Ialuril Soft Gels®) in the management of chronic prostatitis/primary prostate pain syndrome: a single-center prospective study