Heparg | List of Frontiers open access articles

Original Research

Published on 03 Nov 2025

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

in Predictive Toxicology

Kristina Jochum
Veronika Städele
Philip Marx-Stoelting

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690384

1,274 views

Original Research

Published on 30 Oct 2025

Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions

in In Vitro Toxicology

Katharina S. Nitsche
Paul L. Carmichael
Sophie Malcomber
Iris Müller
Hans Bouwmeester

Frontiers in Toxicology

doi 10.3389/ftox.2025.1649393

2,772 views
1 citation

Original Research

Published on 18 Nov 2025

Quercetin alleviates rifampicin-induced hepatocyte injury by modulating the Hippo-YAP signaling pathway

in Hepatobiliary Diseases

Weiwei Liu
Hui Li
Weimin Lu

Frontiers in Medicine

doi 10.3389/fmed.2025.1707248

1,215 views
1 citation

Original Research

Published on 14 Jun 2017

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

in Predictive Toxicology

Franziska Paech
Jamal Bouitbir
Stephan Krähenbühl

Frontiers in Pharmacology

doi 10.3389/fphar.2017.00367

13,191 views
92 citations

Original Research

Published on 21 Nov 2016

Comparison Of Liver Cell Models Using The Basel Phenotyping Cocktail

in Drug Metabolism and Transport

Benjamin Berger
Massimiliano Donzelli
Swarna Maseneni
Franziska Boess
Adrian Roth
Stephan Krähenbühl
Manuel Haschke

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00443

14,973 views
74 citations

Original Research

Published on 17 Nov 2023

Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin

in Cancer Immunity and Immunotherapy

Luise A. Roser
Sonja Luckhardt
Nicole Ziegler
Dominique Thomas
Pia Viktoria Wagner
Georg Damm
Andrea Scheffschick
Philip Hewitt
Michael J. Parnham
Susanne Schiffmann

Frontiers in Immunology

doi 10.3389/fimmu.2023.1275368

6,769 views
10 citations

Original Research

Published on 17 Jul 2020

How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings—A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae

in Analytical Chemistry

Lea Wagmann
Fabian Frankenfeld
Yu Mi Park
Jennifer Herrmann
Svenja Fischmann
Folker Westphal
Rolf Müller
Veit Flockerzi
Markus R. Meyer

Frontiers in Chemistry

doi 10.3389/fchem.2020.00539

9,594 views
50 citations

Original Research

Published on 04 Aug 2025

To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux

in Hepatobiliary Diseases

Chenglin Jia
Biying Hong
Yujie Jiang
Chao Ma
Wei Liu
Yicheng Xu
Jian Chen
Yan Xie
Guangbo Ge
Ye-min Cao

Frontiers in Medicine

doi 10.3389/fmed.2025.1510927

2,146 views
1 citation

Original Research

Published on 20 Nov 2023

Identification of interferon-stimulated genes with modulated expression during hepatitis E virus infection in pig liver tissues and human HepaRG cells

in Viral Immunology

Léa Meyer
Isoline Duquénois
Stacy Gellenoncourt
Marie Pellerin
Aïlona Marcadet-Hauss
Nicole Pavio
Virginie Doceul

Frontiers in Immunology

doi 10.3389/fimmu.2023.1291186

6,328 views
7 citations

Original Research

Published on 23 Oct 2024

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

in Predictive Toxicology

Caitlin Lynch
Ryan Margolis
Jacob Niebler
Jameson Travers
Srilatha Sakamuru
Tongan Zhao
Carleen Klumpp-Thomas
Ruili Huang
Menghang Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448744

3,720 views
2 citations

Original Research

Published on 26 Jul 2018

Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line

in Predictive Toxicology

Longtai You
Xiaoxv Dong
Boran Ni
Jing Fu
Chunjing Yang
Xingbin Yin
Xin Leng
Jian Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00813

5,287 views
37 citations

Original Research

Published on 18 Nov 2021

Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Salix Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells

in Ethnopharmacology

João Victor Dutra Gomes
Corinna Herz
Simone Helmig
Nadja Förster
Inga Mewis
Evelyn Lamy

Frontiers in Pharmacology

doi 10.3389/fphar.2021.779801

4,279 views
9 citations

Original Research

Published on 11 Jul 2017

The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation

in Pharmacogenetics and Pharmacogenomics

Chakradhara Rao S. Uppugunduri
Flavia Storelli
Vid Mlakar
Patricia Huezo-Diaz Curtis
Aziz Rezgui
Yves Théorêt
Denis Marino
Fabienne Doffey-Lazeyras
Yves Chalandon
Peter Bader

Frontiers in Pharmacology

doi 10.3389/fphar.2017.00451

5,162 views
10 citations

Original Research

Accepted on 26 Jan 2026

In silico and in vitro investigation of the mechanisms of the drug-drug interaction between Fludarabine and Busulfan

in Drug Metabolism and Transport

Khalil Ben Hassine
Shannon Robin
Frederic Baleydier
Mourad Mseddi
Vid Mlakar
Jayaraman Muthukumaran
Marc Ansari
Chakradhara Rao Satyanarayana Uppugunduri

Frontiers in Pharmacology

212 views

Original Research

Published on 24 Jul 2018

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

in Drug Metabolism and Transport

Benjamin Berger
Fabio Bachmann
Urs Duthaler
Stephan Krähenbühl
Manuel Haschke

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00774

21,922 views
65 citations

Case Report

Published on 11 Sep 2019

Acute Liver Failure in a Patient Treated With Metamizole

in Predictive Toxicology

Philipp Krisai
Deborah Rudin
David Grünig
Kathrin Scherer
Werner Pichler
Luigi Terracciano
Stephan Krähenbühl

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00996

6,831 views
15 citations

Articles

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions

Quercetin alleviates rifampicin-induced hepatocyte injury by modulating the Hippo-YAP signaling pathway

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

Comparison Of Liver Cell Models Using The Basel Phenotyping Cocktail

Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin

How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings—A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae

To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux

Identification of interferon-stimulated genes with modulated expression during hepatitis E virus infection in pig liver tissues and human HepaRG cells

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line

Drug-Drug Interaction Potential, Cytotoxicity, and Reactive Oxygen Species Production of Salix Cortex Extracts Using Human Hepatocyte-Like HepaRG Cells

The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation

In silico and in vitro investigation of the mechanisms of the drug-drug interaction between Fludarabine and Busulfan

Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug

Acute Liver Failure in a Patient Treated With Metamizole