Hit Compounds Optimization | List of Frontiers open access articles

Original Research

Published on 04 Mar 2026

Integrated transcriptomic, protein, and MicroRNA profiling reveals a conserved pyroptosis-related molecular signature across breast cancer subtypes

in Molecular Diagnostics and Therapeutics

Agata Panfil
Tomasz Sirek
Agata Sirek
Nikola Zmarzły
Michalina Wróbel
Zbigniew Wróbel
Kacper Boroń
Dariusz Boroń
Piotr Ossowski
Martyna Stefaniak

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1759944

234 views

Case Report

Published on 04 Mar 2026

Intraoperative vascular ligation uncovers the role of tumor vasculature in Doege-Potter syndrome: a case report

in Thoracic Oncology

Lin Du
Kai Wei
Na Li
Yajing Sun
Dongmei Liu
Geng Xu
Tao Yang
Xiuqiang Zhang

Frontiers in Oncology

doi 10.3389/fonc.2026.1701711

Original Research

Published on 04 Mar 2026

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

in Comparative Immunology

Jun Jet Hen
Ariel Isaacs
Benjamin Liang
Tony Schountz
Keith Chappell
Paul R. Young
Naphak Modhiran
Daniel Watterson

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743193

180 views

Original Research

Published on 04 Mar 2026

The role of L3 skeletal muscle index in the diagnosis and prognosis prediction of sarcopenia and malnutrition in cancer patients

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Zhuo Chen
Deduo Xu
Xingyun Hou
Zhipeng Wang
Jinping Xiong
Mingying Geng
Jing Xu
Yanyan Gu

Frontiers in Oncology

doi 10.3389/fonc.2026.1759925

Original Research

Published on 04 Mar 2026

Dietary modulation of intestinal integrity and functionality in weaned piglets using short-chain fructooligosaccharides, essential oils and sodium humate

in Animal Nutrition and Metabolism

J. M. Decundo
J. Mozo
D. S. Pérez Gaudio
G. Martínez
S. N. Dieguez
C. P. Bianchi
V. R. Eguía
M. L. Maté
J. P. Lirón
F. A. Amanto

Frontiers in Veterinary Science

doi 10.3389/fvets.2026.1771820

Original Research

Published on 04 Mar 2026

Antibody elution methods for multiplex immunofluorescence of Alzheimer's disease pathology in human post-mortem brain tissue

in Dementia and Neurodegenerative Diseases

Dhiraj Maskey
Hoang-Tuong Nguyen-Hao
Caine C. Smith
Mario Novelli
Julia Stevens
Greg T. Sutherland

Frontiers in Neurology

doi 10.3389/fneur.2026.1760600

133 views

Original Research

Published on 04 Mar 2026

A real-world comparison study of the efficacy of dual-target first-line rescue treatment of human epidermal growth factor receptor 2 positive advanced breast cancer: trastuzumab combined with pertuzumab versus trastuzumab combined with pyrotinib

in Breast Cancer

Liang Zhang
Chao Li
Shubin Song
Fukai Wang
Tingting Ding
Zhengrui Liu
Yuqin Jin
Zhiyong Yu

Frontiers in Oncology

doi 10.3389/fonc.2026.1720851

Original Research

Published on 04 Mar 2026

Predicting cardiovascular events in hemodialysis patients based on the fusion of physicochemical indicators and tongue images: a prospective and multicenter study

in Computational Physiology and Medicine

Kun Zou
Fan Xiao
Shuang Cheng
Qingxiang Wang
Xiaohua He
Jin Wang
Lijuan Dong
Kun Bao
Wu Zhou
Daixin Zhao

Frontiers in Physiology

doi 10.3389/fphys.2026.1782190

Original Research

Published on 04 Mar 2026

Total body water to lean body mass ratio predicts mortality in patients with chronic heart failure: a prospective, observational study

in Clinical Nutrition

Linfeng Xie
Bryan Richard Sasmita
Yuhe Zhao
Jing Chen
Yuanzhu Li
Suxin Luo
Bi Huang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1762912

Original Research

Published on 04 Mar 2026

Dual-level weighted cross-entropy loss function and multi-object region segmentation network evaluation for dynamic knee joint X-ray radiography based on a novel scoring criterion

in Medical Imaging and Nuclear Medicine

Shiming Wang
Tianqi Wu
Weiqing Huang
Jinglong Du
Ziran Chen
Zhibo Xiao
Qi Gao
Yun Liu
Yingying Chen
Peng Guo

Frontiers in Medicine

doi 10.3389/fmed.2026.1768134

Brief Research Report

Published on 04 Mar 2026

Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer after prior vascular endothelial growth factor receptor-targeted therapy (COSMIC-311): outcomes by BRAF status

in Head and Neck Cancer

Marcia S. Brose
Bhumsuk Keam
Jolanta Krajewska
Ana O. Hoff
Fernanda Vaisman
Chia-Chi Lin
Erika Hitre
Daniel W. Bowles
Bruce Robinson
Steven I. Sherman

Frontiers in Oncology

doi 10.3389/fonc.2026.1748566

260 views

Original Research

Published on 04 Mar 2026

Morphological changes and lateralization of the thalamic nuclei in children with growth hormone deficiency

in Pediatric Endocrinology

Joo Young Lee
Sung-min Lim
Jung Hwan Oh
Hyuna Kim
Gang Yi Lee
Bong Gun Lee
Jeong-Kyu Hoh
Seung Yang
Hyun Ju Lee

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1678738

168 views

Original Research

Published on 04 Mar 2026

Beyond body mass index: visceral adiposity and metabolic alterations as early markers of atrial dysfunction and atrial fibrillation in midlife

in Obesity

Angelina Borizanova
Elena Kinova
Natalia Spasova
Assen Goudev

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1775534

Original Research

Published on 04 Mar 2026

Variation of the steroid profile in relation to training in women and its importance for anti-doping testing

in Exercise Physiology

A. Andersson
L. Ekström
O. Salamin
R. Nicoli
A. L. Hirschberg
E. Eklund

Frontiers in Physiology

doi 10.3389/fphys.2026.1733515

Original Research

Published on 04 Mar 2026

Comparison and excitation optimization of commercial quartz tuning forks for QEPAS

in Optics and Photonics

Lei Peng
Yihua Qian
Yaohong Zhao
Qing Wang
Yifeng Zhao
Qiang Fu

Frontiers in Physics

doi 10.3389/fphy.2026.1791440

Original Research

Published on 04 Mar 2026

Astragalus small molecules protect BMSCs from radiation-induced bystander effect and enhance lung cancer radiosensitivity via the primary cilium/TGF-βR1/Smad3 pathway

in Cancer Molecular Targets and Therapeutics

Zhiming Miao
Mengyuan Wu
Sichao Dai
Xin Wang
Yang Yang Li
Fuxian Liu
Zhiwei Liu
Liying Zhang
Yongqi Liu

Frontiers in Oncology

doi 10.3389/fonc.2026.1732029

171 views

Articles

Integrated transcriptomic, protein, and MicroRNA profiling reveals a conserved pyroptosis-related molecular signature across breast cancer subtypes

Intraoperative vascular ligation uncovers the role of tumor vasculature in Doege-Potter syndrome: a case report

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

The role of L3 skeletal muscle index in the diagnosis and prognosis prediction of sarcopenia and malnutrition in cancer patients

Dietary modulation of intestinal integrity and functionality in weaned piglets using short-chain fructooligosaccharides, essential oils and sodium humate

Antibody elution methods for multiplex immunofluorescence of Alzheimer's disease pathology in human post-mortem brain tissue

A real-world comparison study of the efficacy of dual-target first-line rescue treatment of human epidermal growth factor receptor 2 positive advanced breast cancer: trastuzumab combined with pertuzumab versus trastuzumab combined with pyrotinib

Predicting cardiovascular events in hemodialysis patients based on the fusion of physicochemical indicators and tongue images: a prospective and multicenter study

Total body water to lean body mass ratio predicts mortality in patients with chronic heart failure: a prospective, observational study

Dual-level weighted cross-entropy loss function and multi-object region segmentation network evaluation for dynamic knee joint X-ray radiography based on a novel scoring criterion

Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer after prior vascular endothelial growth factor receptor-targeted therapy (COSMIC-311): outcomes by BRAF status

Morphological changes and lateralization of the thalamic nuclei in children with growth hormone deficiency

Beyond body mass index: visceral adiposity and metabolic alterations as early markers of atrial dysfunction and atrial fibrillation in midlife

Variation of the steroid profile in relation to training in women and its importance for anti-doping testing

Comparison and excitation optimization of commercial quartz tuning forks for QEPAS

Astragalus small molecules protect BMSCs from radiation-induced bystander effect and enhance lung cancer radiosensitivity via the primary cilium/TGF-βR1/Smad3 pathway