Hypercomplex | List of Frontiers open access articles

Original Research

Published on 01 May 2026

Peptidomics-based identification of endogenous free peptides from Ophiocordyceps sinensis and functional validation of immunomodulatory peptide WALGT

in Experimental Pharmacology and Drug Discovery

Wei Wang
Yuanping Liu
Yunjie Hu
Huan Yang
Mengjiao Zhang
Congcong Li
Yuting Mu
Lilian Zhao
Yuping Wan
Yun Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1748787

179 views

Original Research

Published on 01 May 2026

Mast cells shape early pulmonary inflammation and regulate dendritic cell abundance and localization after chemical induced lung injury

in Inflammation

Matthew Gibb
Colin Anderson
Angela N. Reinert
Troy Schedin
Jonathan Boyd
Julie A. Reisz
Neera Tewari-Singh
Alison K. Bauer
Jared M. Brown

Frontiers in Immunology

doi 10.3389/fimmu.2026.1763509

287 views

Review

Published on 01 May 2026

Pancreatitis: correcting CFTR expression and function as a promising effective treatment

in Gastrointestinal Sciences

Paramita Sarkar
Wei-Yin Lin
Ava Movahed Abtahi
Woo Young Chung
Shmuel Muallem

Frontiers in Physiology

doi 10.3389/fphys.2026.1813824

208 views

Original Research

Published on 01 May 2026

The long noncoding RNA lnc-FAM164A1-ACLY axis promotes pro-inflammatory responses in human primary macrophages: a systems approach

in Molecular Innate Immunity

Jian-Guo Wang
Shiori Ito
Daiki Hosokawa
Keishi Nihira
Julius L. Decano
Lang Ho Lee
Hideyuki Higashi
Arda Halu
Peter C. Mattson
Gabriela Amaral

Frontiers in Immunology

doi 10.3389/fimmu.2026.1776849

222 views

Original Research

Published on 01 May 2026

Plasma proteome-wide Mendelian randomization reveals multi-ancestry drug targets for gastric cancer

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Peng Zhi
Yan Cui
Guanghui Xue
Lingyu Qiao
Jie Geng
Zhengyao Chang
Yinmei Xu
Juanjuan Yan
Yingli Wang
Chenghui Zhao

Frontiers in Oncology

doi 10.3389/fonc.2026.1821512

180 views

Original Research

Published on 01 May 2026

Incidence and risk factors of low testosterone in infertile men with normal sperm concentration

in Reproduction

Chyau-Wen Lin
Eric Yi-Hsiu Huang
William J. Huang
I-Shen Huang

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1797678

308 views

Original Research

Published on 01 May 2026

A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model

in Comparative Immunology

Leonie Bettin
Christine Unterweger
Maximiliane Dippel
Tamara Borysova
Maria Stadler
Jonathan Harris
James Rozzelle
Daisy Arroyo
Jeff Fairman
Taylor B. Poston

Frontiers in Immunology

doi 10.3389/fimmu.2026.1816737

237 views

Original Research

Published on 01 May 2026

Pre-ablation derived neutrophil-to-lymphocyte ratio is associated with time to complete disappearance after thermal ablation of benign thyroid nodules: a retrospective cohort study

in Thyroid Endocrinology

Pei-Cheng Li
Zhong-Hua Wang
Zhen-Long Zhao
Ying Wei
Jie Wu
Wen-Jia Cai
Yan Li
Li-Li Peng
Yu-Jie Sui
Ming-An Yu

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1817575

183 views

Original Research

Published on 01 May 2026

Exploring the relationship between cognitive function and frailty in middle-aged and older adults Chinese adults: evidence from the CHARLS database

in Public Mental Health

Biqi Zu
Ting Wang
Guangchuan Li
Yajin Chen
Libin An
Juan Yin
Wentao Li

Frontiers in Public Health

doi 10.3389/fpubh.2026.1825820

184 views

Review

Published on 01 May 2026

Oxidative stress and endoplasmic reticulum stress in acute kidney injury: mechanistic crosstalk and therapeutic modulation

in Nephrology

Xiaoqi Xu
Qiongqiong Xing
Hanqing Li
Zichao Ding
Xianqing Ren

Frontiers in Medicine

doi 10.3389/fmed.2026.1808254

181 views

Original Research

Published on 01 May 2026

Prognostic factors and survival outcomes in patients undergoing limb-sparing surgery for primary malignant bone tumors

in Surgical Oncology

Chunan Zhong
Yuzhe Zhang
Jijun Liu
Lin Wang
Songtao Gao

Frontiers in Oncology

doi 10.3389/fonc.2026.1680456

151 views

Case Report

Published on 01 May 2026

Upadacitinib for atopic dermatitis induced by secukinumab in patients with refractory ankylosing spondylitis:a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jinxia Fang
Shaobiao Pan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1737773

123 views

Original Research

Published on 01 May 2026

Learning environment, school–enterprise cooperation, and student motivation as predictors of employment competitiveness among undergraduates in application-oriented universities

in Higher Education

Chen Lei
Connie Shin

Frontiers in Education

doi 10.3389/feduc.2026.1805477

177 views

Review

Published on 01 May 2026

Thinking out of the (Olympic) box: is it time to reconsider permanent hosting for sustainable Olympics? A conceptual review

in Sports Politics, Policy and Law

Athanasios (Sakis) Pappous

Frontiers in Sports and Active Living

doi 10.3389/fspor.2026.1778441

255 views

Policy and Practice Reviews

Published on 01 May 2026

Quantitative research and implications on policy texts of China’s maritime strategic scientific and technological strength: an analysis based on the three-dimensional framework of “instrument–objective–actor”

in Marine Affairs and Policy

Xiaoyu Cui
Wanglai Cui
Yiqian Ding
Cheng Lang
Yunjie Zhang
Xiaoxiao Lin

Frontiers in Marine Science

doi 10.3389/fmars.2026.1801449

195 views

Specialty Grand Challenge

Published on 01 May 2026

The algorithmic patient: on the ontological disruption of selfhood, suffering, and healing in the age of artificial intelligence

in Health Psychology

Changiz Mohiyeddini

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1809692

263 views

Articles

Peptidomics-based identification of endogenous free peptides from Ophiocordyceps sinensis and functional validation of immunomodulatory peptide WALGT

Mast cells shape early pulmonary inflammation and regulate dendritic cell abundance and localization after chemical induced lung injury

Pancreatitis: correcting CFTR expression and function as a promising effective treatment

The long noncoding RNA lnc-FAM164A1-ACLY axis promotes pro-inflammatory responses in human primary macrophages: a systems approach

Plasma proteome-wide Mendelian randomization reveals multi-ancestry drug targets for gastric cancer

Incidence and risk factors of low testosterone in infertile men with normal sperm concentration

A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model

Pre-ablation derived neutrophil-to-lymphocyte ratio is associated with time to complete disappearance after thermal ablation of benign thyroid nodules: a retrospective cohort study

Exploring the relationship between cognitive function and frailty in middle-aged and older adults Chinese adults: evidence from the CHARLS database

Oxidative stress and endoplasmic reticulum stress in acute kidney injury: mechanistic crosstalk and therapeutic modulation

Prognostic factors and survival outcomes in patients undergoing limb-sparing surgery for primary malignant bone tumors

Upadacitinib for atopic dermatitis induced by secukinumab in patients with refractory ankylosing spondylitis:a case report

Learning environment, school–enterprise cooperation, and student motivation as predictors of employment competitiveness among undergraduates in application-oriented universities

Thinking out of the (Olympic) box: is it time to reconsider permanent hosting for sustainable Olympics? A conceptual review

Quantitative research and implications on policy texts of China’s maritime strategic scientific and technological strength: an analysis based on the three-dimensional framework of “instrument–objective–actor”

The algorithmic patient: on the ontological disruption of selfhood, suffering, and healing in the age of artificial intelligence