Hyperinflammatory Syndrome | List of Frontiers open access articles

Case Report

Published on 27 Apr 2026

Successful rechallenge of BRAF/MEK inhibitor with ruxolitinib in BRAF/MEK inhibitor-induced hemophagocytic lymphohistiocytosis like hyperinflammatory syndrome in BRAF V600E-mutated lung adenocarcinoma: a case report

in Thoracic Oncology

Simran Chandra
Sagar Hansraj
Aakriti Adhikari
Ben Ponvilawan
Addison Tolentino
Dhruv Bansal

Frontiers in Oncology

doi 10.3389/fonc.2026.1795399

374 views

Case Report

Published on 15 Aug 2022

Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma

in Intensive Care Medicine and Anesthesiology

Juan Carlos Ruiz-Rodríguez
Luis Chiscano-Camón
Adolf Ruiz-Sanmartin
Clara Palmada
Ivan Bajaña
Gloria Iacoboni
Camilo Bonilla
Alejandra García-Roche
Erika Paola Plata-Menchaca
Carolina Maldonado

Frontiers in Medicine

doi 10.3389/fmed.2022.925751

3,827 views
10 citations

Review

Published on 19 Sep 2025

Treating and triggering hyperinflammation: tackling hemophagocytic lymphohistiocytosis and HLH-like syndromes in the pediatric cell therapy and critical care setting

in Pediatric Oncology

Holly Wobma
Lauren A. Henderson
Christine N. Duncan
Susan E. Prockop
Adrienne G. Randolph
Barbara A. Degar
Leslie E. Lehmann
Susanne H. C. Baumeister

Frontiers in Oncology

doi 10.3389/fonc.2025.1631557

3,736 views

Review

Published on 16 Mar 2023

Serum amyloid A—A potential therapeutic target for hyper-inflammatory syndrome associated with COVID-19

in Translational Medicine

Eman M. Almusalami
Anthony Lockett
Albert Ferro
John Posner

Frontiers in Medicine

doi 10.3389/fmed.2023.1135695

6,454 views
20 citations

Case Report

Published on 11 Apr 2023

Case report: High-risk acute promyelocytic leukemia and COVID-19-related myocarditis one patient, two cytokine storms

in Hematologic Malignancies

Alexandra Ghiaur
Cristina Doran
Bogdan Ionescu
Lacramioara –Andreea Mohorea-Neata
Camelia Stancioaica
Roxana Hirjan
Aurelia Tatic
Mihaela Cirstea
Didona Vasilache
Dana Tabac

Frontiers in Oncology

doi 10.3389/fonc.2023.1095154

4,239 views
2 citations

Case Report

Published on 03 Feb 2026

A fatal course of hemophagocytic lymphohistiocytosis in a child with homozygous ERCC6L2 defect and heterozygous ADA2 variant: a case report

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Szymon Lulek
Katarzyna Bąbol-Pokora
Monika Radwańska
Daniel Popiel
Magdalena Reich
Wojciech Młynarski
Radosław Chaber

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717567

965 views

Case Report

Published on 13 Nov 2025

Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient

in Pediatric Oncology

Filipa Paixão
André Salvada
Susana Santos
Catarina Amorim
Carlos Escobar

Frontiers in Pediatrics

doi 10.3389/fped.2025.1719708

1,479 views
1 citation

Case Report

Published on 09 Sep 2021

Case Report: Lymphohistiocytic Myocarditis With Severe Cardiogenic Shock Requiring Mechanical Cardiocirculatory Support in Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection

in General Cardiovascular Medicine

Xavier Bemtgen
Karin Klingel
Markus Hufnagel
Ales Janda
Christoph Bode
Dawid L. Staudacher
Alexander Supady
Ilona Jandova

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2021.716198

9,158 views
20 citations

Review

Published on 08 May 2020

Cell Versus Cytokine – Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity

in Autoimmune and Autoinflammatory Disorders

Oliver Wegehaupt
Katharina Wustrau
Kai Lehmberg
Stephan Ehl

Frontiers in Immunology

doi 10.3389/fimmu.2020.00808

12,507 views
37 citations

Original Research

Published on 09 Jun 2020

Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets

in T Cell Biology

Donatella Galgano
Tayebeh Soheili
Matthias Voss
Lamberto Torralba-Raga
Bianca Tesi
Frank Cichocki
Isabelle Andre
Jens Rettig
Marina Cavazzana
Yenan Bryceson

Frontiers in Immunology

doi 10.3389/fimmu.2020.01154

6,767 views
8 citations

Original Research

Published on 09 Sep 2024

Etiological stratification and prognostic assessment of haemophagocytic lymphohistiocytosis by machine learning on onco-mNGS data and clinical data

in Systems Immunology

Lin Wu
Xuefang Cao
Jingshi Wang
Qi Kong
Junxia Hu
Lin Shi
Liurui Dou
Deli Song
Leilei Chen
Mengyuan Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2024.1390298

4,094 views
2 citations

Case Report

Published on 01 Oct 2025

Case Report: Longitudinal mass cytometry profiling of a patient with disseminated histoplasmosis and secondary hemophagocytic lymphohistiocytosis

in Cytokines and Soluble Mediators in Immunity

Jiaying Zhang
Longyu Zhang
Zixin Kang
Danlei Mou
Lianchun Liang
Yu Chen
Yingmei Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660382

2,695 views

Mini Review

Published on 16 Feb 2021

Use of the JAK Inhibitor Ruxolitinib in the Treatment of Hemophagocytic Lymphohistiocytosis

in Primary Immunodeficiencies

Camille Keenan
Kim E. Nichols
Sabrin Albeituni

Frontiers in Immunology

doi 10.3389/fimmu.2021.614704

41,585 views
172 citations

Original Research

Published on 21 Oct 2022

Risk factors of early death in pediatric hemophagocytic lymphohistocytosis: Retrospective cohort study

in Pediatric Critical Care

Lijun Zhang
Lei Dai
Deyuan Li

Frontiers in Pediatrics

doi 10.3389/fped.2022.1031432

3,601 views
2 citations

Case Report

Published on 20 Aug 2025

Case Report: FAS spontaneous mutation in a familial hemophagocytic lymphohistiocytosis patient with a complex heterozygous mutation in PRF1

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Wenwen Ding
Danni Li
Qi Yu
Yuping Wang
Lei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613433

1,872 views

Original Research

Published on 07 Mar 2022

Metformin Use in Relation to Clinical Outcomes and Hyperinflammatory Syndrome Among COVID-19 Patients With Type 2 Diabetes: A Propensity Score Analysis of a Territory-Wide Cohort

in Clinical Diabetes

Carlos K. H. Wong
David T. W. Lui
Angel Y. C. Lui
Marshall C. H. Low
Ashley C. Y. Kwok
Kristy T. K. Lau
Ivan C. H. Au
Xi Xiong
Matthew S. H. Chung
Eric H. Y. Lau

Frontiers in Endocrinology

doi 10.3389/fendo.2022.810914

5,531 views
7 citations

Articles

Successful rechallenge of BRAF/MEK inhibitor with ruxolitinib in BRAF/MEK inhibitor-induced hemophagocytic lymphohistiocytosis like hyperinflammatory syndrome in BRAF V600E-mutated lung adenocarcinoma: a case report

Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma

Treating and triggering hyperinflammation: tackling hemophagocytic lymphohistiocytosis and HLH-like syndromes in the pediatric cell therapy and critical care setting

Serum amyloid A—A potential therapeutic target for hyper-inflammatory syndrome associated with COVID-19

Case report: High-risk acute promyelocytic leukemia and COVID-19-related myocarditis one patient, two cytokine storms

A fatal course of hemophagocytic lymphohistiocytosis in a child with homozygous ERCC6L2 defect and heterozygous ADA2 variant: a case report

Case Report: Conservative management of hemophagocytic lymphohistiocytosis with fulminant hepatic failure in a pediatric leukemia patient

Case Report: Lymphohistiocytic Myocarditis With Severe Cardiogenic Shock Requiring Mechanical Cardiocirculatory Support in Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection

Cell Versus Cytokine – Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity

Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets

Etiological stratification and prognostic assessment of haemophagocytic lymphohistiocytosis by machine learning on onco-mNGS data and clinical data

Case Report: Longitudinal mass cytometry profiling of a patient with disseminated histoplasmosis and secondary hemophagocytic lymphohistiocytosis

Use of the JAK Inhibitor Ruxolitinib in the Treatment of Hemophagocytic Lymphohistiocytosis

Risk factors of early death in pediatric hemophagocytic lymphohistocytosis: Retrospective cohort study

Case Report: FAS spontaneous mutation in a familial hemophagocytic lymphohistiocytosis patient with a complex heterozygous mutation in PRF1

Metformin Use in Relation to Clinical Outcomes and Hyperinflammatory Syndrome Among COVID-19 Patients With Type 2 Diabetes: A Propensity Score Analysis of a Territory-Wide Cohort