Hypothesis Guided Research | List of Frontiers open access articles

Original Research

Published on 12 Jun 2025

Radiation therapy induced intestinal barrier damage and repair process - differences in salivary metabolites and monitoring of intestinal barrier function

in Cancer Immunity and Immunotherapy

Zhang Jingjing
Wang Kun
Qiao Yanyu
Zhang Mengjie
Chen Yunqing
Tian Yulong
Jiao Xuelong
Tan Xiaojie
Jiang Haitao
Hou Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590219

120 views

Original Research

Published on 12 Jun 2025

The DEAD-box RNA helicase 27 negatively regulates the replication of porcine reproductive and respiratory syndrome virus by mediating GP2a autophagy degradation and inducing interferon-β production

in Viral Immunology

Binghua Chen
Yunyan Luo
Yongjie Chen
Jingxing Wang
Jiecong Yan
Zhan He
Fangfang Li
Chunhe Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587647

205 views

Hypothesis and Theory

Published on 12 Jun 2025

Cost-effective screening strategy to prevent venous thromboembolism in combined oral contraceptive users

in Reproduction

Jonathan Douxfils

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1559162

143 views

Original Research

Published on 12 Jun 2025

CD4 T cells correlate with better prognosis in medulloblastoma

in Cancer Molecular Targets and Therapeutics

Jin Zhang
Siqi Ren
Shuting Li
Yuan Wang
Lulu Wan
Wenchao Gao
Huaying Sun
Xiaojun Gong
Miao Li
Yanling Sun

Frontiers in Oncology

doi 10.3389/fonc.2025.1593329

118 views

Original Research

Published on 12 Jun 2025

Single cell dissection reveals SFRP2+ fibroblasts amplifying inflammatory responses in oral lichen planus

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Juehua Cheng
Jia Liu
Yuchi Zhu
Jingjing Yang
Yanlin Geng
Yuan Fan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1553963

147 views

Original Research

Published on 12 Jun 2025

Regional and patient-level determinants of endoscopic utilization in rural healthcare: a multi-level analysis

in Cancer Epidemiology and Prevention

Muye Ma
Pengfei Li
Zhengyang Lu
Nan Zhang
Suzhen Wang
Youhua Lu
Jinming Yu

Frontiers in Oncology

doi 10.3389/fonc.2025.1596332

138 views

Original Research

Published on 12 Jun 2025

Diagnostic value of exosome non-coding RNAs as non-invasive biomarkers in gastric cancer: a meta-analysis

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Qiumiao Xu
Qinghong Yan
Zhijiang Dai
Xiaoting Chen
Tongwei Liu
Chengjin Peng
Guoxin Huang
Xinyao Liu
Jingbin Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1570020

161 views

Original Research

Published on 12 Jun 2025

Blood metabolome shows signatures of metabolic dysregulation in obese and overweight subjects that can be predicted by machine learning applied to heart rate variability

in Metabolomics

Andrea Di Credico
David Perpetuini
Pascal Izzicupo
Giulia Gaggi
Claudia Rossi
Arcangelo Merla
Barbara Ghinassi
Angela Di Baldassarre
Ines Bucci

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1561987

231 views

Original Research

Published on 12 Jun 2025

Average optical path length estimation in a slab of arbitrary finite thickness

in Atmospheric Remote Sensing

Tim Kindervatter
Wei Li
Nan Chen
Yuping Huang
Yongxiang Hu
Snorre Stamnes
Xiaomei Lu
Børge Hamre
Jakob J. Stamnes
Tomonori Tanikawa

Frontiers in Remote Sensing

doi 10.3389/frsen.2025.1565245

250 views

Original Research

Published on 12 Jun 2025

Universal nomogram for predicting referable diabetic retinopathy: a validated model for community and ophthalmic outpatient populations using easily accessible indicators

in Clinical Diabetes

Niu Dongling
Kang Ziwei
Sun Juanling
Zhang Li
Wang Chang
Lei Ting
Liu Hongli
Zhang Yanchun

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1557166

Original Research

Published on 12 Jun 2025

Self-reported help-seeking behavior in the event of mental disorders among adults in Poland

in Public Mental Health

Aleksandra Lewandowska
Mateusz Jankowski
Mariusz Gujski
Paulina Mularczyk-Tomczewska
Agata Szulc
Andrzej Silczuk

Frontiers in Public Health

doi 10.3389/fpubh.2025.1612066

4,114 views

Original Research

Published on 12 Jun 2025

Global and regional burden of nasopharyngeal cancer in older adults attributable to smoking and high alcohol use from 1990 to 2021

in Aging and Public Health

Xiao Wang
Ying Li
Yujie Luo
Xin Song

Frontiers in Public Health

doi 10.3389/fpubh.2025.1614389

145 views

Original Research

Published on 12 Jun 2025

Deep learning-based object detection for environmental monitoring using big data

in Big Data, AI, and the Environment

Wenbo Lin
Tingting Li
Xiao Li

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1566224

301 views

Review

Published on 12 Jun 2025

NK cell dysfunction in antiphospholipid syndrome

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Anush Martirosyan
Eva Kriegova
Gayane Manukyan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593705

240 views

Original Research

Published on 12 Jun 2025

Successful coordination of the distributed network, Natural Hazards Engineering Research Infrastructure

in Earthquake Engineering

Cheryl Ann Blain
Julio A. Ramirez
Billy L. Edge
William Holmes
Marti LaChance
Robin Nelson
Ian Robertson
Dan Zehner

Frontiers in Built Environment

doi 10.3389/fbuil.2025.1589067

186 views

Original Research

Published on 12 Jun 2025

Psychological symptoms in perimenarcheal adolescents: association with PCOS risk factors

in Reproduction

Heidi Vanden Brink
Kathleen C. McCormick
Marla E. Lujan
Jane Chang
Lisa Ipp
Erika L. Mudrak
Anisah Alladeen
Hannah Lamar
Joy Y. Kim
Jane Mendle

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1551958

199 views

Articles

Radiation therapy induced intestinal barrier damage and repair process - differences in salivary metabolites and monitoring of intestinal barrier function

The DEAD-box RNA helicase 27 negatively regulates the replication of porcine reproductive and respiratory syndrome virus by mediating GP2a autophagy degradation and inducing interferon-β production

Cost-effective screening strategy to prevent venous thromboembolism in combined oral contraceptive users

CD4 T cells correlate with better prognosis in medulloblastoma

Single cell dissection reveals SFRP2+ fibroblasts amplifying inflammatory responses in oral lichen planus

Regional and patient-level determinants of endoscopic utilization in rural healthcare: a multi-level analysis

Diagnostic value of exosome non-coding RNAs as non-invasive biomarkers in gastric cancer: a meta-analysis

Blood metabolome shows signatures of metabolic dysregulation in obese and overweight subjects that can be predicted by machine learning applied to heart rate variability

Average optical path length estimation in a slab of arbitrary finite thickness

Universal nomogram for predicting referable diabetic retinopathy: a validated model for community and ophthalmic outpatient populations using easily accessible indicators

Self-reported help-seeking behavior in the event of mental disorders among adults in Poland

Global and regional burden of nasopharyngeal cancer in older adults attributable to smoking and high alcohol use from 1990 to 2021

Deep learning-based object detection for environmental monitoring using big data

NK cell dysfunction in antiphospholipid syndrome

Successful coordination of the distributed network, Natural Hazards Engineering Research Infrastructure

Psychological symptoms in perimenarcheal adolescents: association with PCOS risk factors