Kcc2 | List of Frontiers open access articles

Original Research

Published on 24 Jun 2022

Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons

in Cellular Biochemistry

Francis J. Prael III
Kwangho Kim
Yu Du
Brittany D. Spitznagel
Gary A. Sulikowski
Eric Delpire
C. David Weaver

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.912812

11,579 views
21 citations

Original Research

Published on 08 Apr 2025

Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures

in Neuroenergetics and Brain Health

Leticia Granados-Rojas
Leonardo Hernández-López
Emmanuel Leonardo Bahena-Alvarez
Tarsila Elizabeth Juárez-Zepeda
Verónica Custodio
Joyce Graciela Martínez-Galindo
Karina Jerónimo-Cruz
Miguel Tapia-Rodríguez
America Vanoye-Carlo
Pilar Duran

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1489407

2,966 views

Original Research

Published on 24 May 2023

Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation

in Brain Disease Mechanisms

Domenico Del Turco
Mandy H. Paul
Jessica Schlaudraff
Julia Muellerleile
Fran Bozic
Mario Vuksic
Peter Jedlicka
Thomas Deller

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1118746

5,962 views
5 citations

Original Research

Published on 01 Nov 2011

Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus

in Cellular Neurophysiology

Ilgam Khalilov
Geneviève Chazal
Ilona Chudotvorova
Christophe Pellegrino
Severine Corby
Nadine Ferrand
Olena Gubkina
Romain Nardou
Roman Tyzio
Sumii Yamamoto

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2011.00023

8,336 views
38 citations

Brief Research Report

Published on 24 Nov 2022

Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments

in Pain Mechanisms and Modulators

Michele Yeo
Qiaojuan Zhang
LeAnne Ding
Xiangjun Shen
Yong Chen
Wolfgang Liedtke

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.911606

8,186 views
3 citations

Original Research

Published on 16 Mar 2022

Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons

in Neuroplasticity and Development

Kirill Zavalin
Anjana Hassan
Cary Fu
Eric Delpire
Andre H. Lagrange

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.826427

8,510 views
13 citations

Original Research

Published on 18 Aug 2025

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q

in Molecular Signalling and Pathways

Jinglin Ji
Catherine Choi
Christopher E. Bope
Jacob S. Dengler
Stephen J. Moss
Joshua L. Smalley

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1645428

3,359 views

Original Research

Published on 23 Jul 2019

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

in Neuroplasticity and Development

Yvonne E. Moore
Leslie C. Conway
Heike J. Wobst
Nicholas J. Brandon
Tarek Z. Deeb
Stephen J. Moss

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2019.00173

10,823 views
48 citations

Original Research

Published on 15 May 2013

Immunolocalization of cation-chloride cotransporters in the developing and mature spinal cord of opossums, Monodelphis domestica

Ha-Loan Phan
Jean-François Pflieger

Frontiers in Neuroanatomy

doi 10.3389/fnana.2013.00012

5,916 views
3 citations

Original Research

Published on 12 Oct 2015

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

in Cellular Neuropathology

Nancy D. Merner
Madison R. Chandler
Cynthia Bourassa
Bo Liang
Arjun R. Khanna
Patrick Dion
Guy A. Rouleau
Kristopher T. Kahle

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2015.00386

11,934 views
109 citations

Mini Review

Published on 15 Nov 2019

Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation

in Cellular Neurophysiology

Phan Q. Duy
Wyatt B. David
Kristopher T. Kahle

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2019.00515

9,563 views
35 citations

Review

Published on 13 May 2022

Long March Toward Safe and Effective Analgesia by Enhancing Gene Expression of Kcc2: First Steps Taken

in Pain Mechanisms and Modulators

Wolfgang Liedtke

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.865600

6,650 views
6 citations

Original Research

Published on 03 Feb 2022

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

in Brain Disease Mechanisms

Tanja Herrmann
Melanie Gerth
Ralf Dittmann
Daniel Pensold
Martin Ungelenk
Lutz Liebmann
Christian A. Hübner

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.807090

9,757 views
10 citations

Original Research

Published on 21 Aug 2018

M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation

in Molecular Signalling and Pathways

Li Wan
Liang Ren
Lulan Chen
Guoxiang Wang
Xu Liu
Benjamin H. Wang
Yun Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2018.00287

6,916 views
22 citations

Review

Published on 15 Dec 2022

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology

in Membrane Physiology and Membrane Biophysics

Zuliyaer Talifu
Yunzhu Pan
Han Gong
Xin Xu
Chunjia Zhang
Degang Yang
Feng Gao
Yan Yu
Liangjie Du
Jianjun Li

Frontiers in Physiology

doi 10.3389/fphys.2022.1045520

13,141 views
23 citations

Review

Published on 21 Feb 2012

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

in Cellular Neurophysiology

Ingrid Chamma
Quentin Chevy
Jean Christophe Poncer
Sabine Levi

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2012.00005

45,253 views
190 citations

Articles

Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons

Effects of the ketogenic diet on dentate gyrus and CA3 KCC2 expression in male rats with electrical amygdala kindling-induced seizures

Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation

Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus

Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments

Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons

KCC2 inhibition and neuronal hyperexcitability promote extrinsic apoptosis dependent upon C1q

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function

Immunolocalization of cation-chloride cotransporters in the developing and mature spinal cord of opossums, Monodelphis domestica

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation

Long March Toward Safe and Effective Analgesia by Enhancing Gene Expression of Kcc2: First Steps Taken

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission