Keap1 | List of Frontiers open access articles

Original Research

Published on 13 Jun 2024

KEAP1 overexpression is correlated with poor prognosis and immune infiltration in liver hepatocellular carcinoma

in Hepatobiliary Diseases

Xin Wei
Yigui Tang
Meijuan Zheng
Yuanhong Xu
Zhongxin Wang

Frontiers in Medicine

doi 10.3389/fmed.2024.1391843

2,728 views
3 citations

Original Research

Published on 19 Jun 2024

Neutrophil in the suppressed immune microenvironment: Critical prognostic factor for lung adenocarcinoma patients with KEAP1 mutation

in Cancer Genetics and Oncogenomics

Zhongzhao Wang
Haojue Wang
Mingjia Liu
Xinhang Ning
Yang Chen
Hao Tang

Frontiers in Genetics

doi 10.3389/fgene.2024.1382421

2,250 views
2 citations

Original Research

Published on 07 Jan 2026

KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer

in Cancer Genetics

Nicholas E. Bambach
Julio C. Ricarte-Filho
Erin R. Reichenberger
Christian Hernandez-Padilla
Kyle Hinkle
Amber Isaza
Andrew J. Bauer
Aime T. Franco

Frontiers in Oncology

doi 10.3389/fonc.2025.1685379

2,266 views

Original Research

Published on 18 Feb 2020

CRISPR/Cas9-Induced Loss of Keap1 Enhances Anti-oxidation in Rat Adipose-Derived Mesenchymal Stem Cells

in Epilepsy

Yiling Hu
Shubao Liu
Bing-Mei Zhu

Frontiers in Neurology

doi 10.3389/fneur.2019.01311

6,731 views
24 citations

Original Research

Published on 30 May 2018

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice

in Translational Pharmacology

Jing Liu
Wencai Li
Manoj H. Limbu
Yiping Li
Zhi Wang
Zhengyuan Cheng
Xiaoyi Zhang
Pingsheng Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00555

4,149 views
7 citations

Original Research

Published on 08 Sep 2021

Dexmedetomidine Relieves Neuropathic Pain in Rats With Chronic Constriction Injury via the Keap1–Nrf2 Pathway

in Molecular and Cellular Pathology

Yatao Liu
Wei Liu
Xiao-Qing Wang
Zhan-Hai Wan
Yong-Qiang Liu
Meng-Jie Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.714996

5,397 views
22 citations

Case Report

Published on 20 Sep 2016

A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter

in Thyroid Endocrinology

Eijun Nishihara
Akira Hishinuma
Takahiko Kogai
Nami Takada
Mitsuyoshi Hirokawa
Shuji Fukata
Mitsuru Ito
Tomonori Yabuta
Mitsushige Nishikawa
Hirotoshi Nakamura

Frontiers in Endocrinology

doi 10.3389/fendo.2016.00131

5,419 views
24 citations

Mini Review

Published on 08 Apr 2021

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

in Cellular and Molecular Mechanisms of Brain-aging

Dmitry M. Hushpulian
Navneet Ammal Kaidery
Manuj Ahuja
Andrey A. Poloznikov
Sudarshana M. Sharma
Irina G. Gazaryan
Bobby Thomas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.673205

12,106 views
38 citations

Review

Published on 04 May 2017

The KEAP1–NRF2 System in Cancer

in Cancer Molecular Targets and Therapeutics

Keiko Taguchi
Masayuki Yamamoto

Frontiers in Oncology

doi 10.3389/fonc.2017.00085

68,370 views
527 citations

Original Research

Published on 27 Nov 2018

DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop

in Inflammation

Menglin Fan
Yanan Li
Chunhua Yao
Xiufeng Liu
Jihua Liu
Boyang Yu

Frontiers in Immunology

doi 10.3389/fimmu.2018.02762

9,329 views
50 citations

Perspective

Published on 05 Dec 2024

Clinical perspectives on the value of testing for STK11 and KEAP1 mutations in advanced NSCLC

in Thoracic Oncology

Michelle Shiller
Melissa Johnson
Robert Auber
Sandip Pravin Patel

Frontiers in Oncology

doi 10.3389/fonc.2024.1459737

5,942 views
6 citations

Review

Published on 08 Jan 2024

Post-translational modifications of Keap1: the state of the art

in Signaling

Yunjia Song
Ying Qu
Caiyun Mao
Rong Zhang
Deyou Jiang
Xutao Sun

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2023.1332049

8,937 views
42 citations

Original Research

Published on 01 May 2026

MiR-200a-3p protects against myocardial ischemia-reperfusion injury via KEAP1–NRF2 signaling

in Redox Physiology

Yanbo Zhao
Lulu Liu
Xiaohua Shen
Min Wang
Meihui Wang
Lingling Sun
Kai Zhang

Frontiers in Physiology

doi 10.3389/fphys.2026.1826306

719 views

Review

Published on 16 Oct 2018

Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective

in Inflammation Pharmacology

Kenji Hashimoto

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01182

16,144 views
102 citations

Original Research

Published on 28 Feb 2022

Exploring the Mechanism of Danshensu in the Treatment of Doxorubicin-Induced Cardiotoxicity Based on Network Pharmacology and Experimental Evaluation

in General Cardiovascular Medicine

Jia-ying Qi
Ya-kun Yang
Chuan Jiang
Yang Zhao
Yong-chao Wu
Xue Han
Xuan Jing
Zhong-lin Wu
Li Chu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2022.827975

5,218 views
25 citations

Original Research

Published on 22 Apr 2024

TP53 co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside KRAS, STK11 and KEAP1 mutations

in Thoracic Oncology

Armin Frille
Myriam Boeschen
Hubert Wirtz
Mathias Stiller
Hendrik Bläker
Maximilian von Laffert

Frontiers in Oncology

doi 10.3389/fonc.2024.1357583

4,844 views
19 citations

Articles

KEAP1 overexpression is correlated with poor prognosis and immune infiltration in liver hepatocellular carcinoma

Neutrophil in the suppressed immune microenvironment: Critical prognostic factor for lung adenocarcinoma patients with KEAP1 mutation

KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer

CRISPR/Cas9-Induced Loss of Keap1 Enhances Anti-oxidation in Rat Adipose-Derived Mesenchymal Stem Cells

Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice

Dexmedetomidine Relieves Neuropathic Pain in Rats With Chronic Constriction Injury via the Keap1–Nrf2 Pathway

A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

The KEAP1–NRF2 System in Cancer

DC32, a Dihydroartemisinin Derivative, Ameliorates Collagen-Induced Arthritis Through an Nrf2-p62-Keap1 Feedback Loop

Clinical perspectives on the value of testing for STK11 and KEAP1 mutations in advanced NSCLC

Post-translational modifications of Keap1: the state of the art

MiR-200a-3p protects against myocardial ischemia-reperfusion injury via KEAP1–NRF2 signaling

Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective

Exploring the Mechanism of Danshensu in the Treatment of Doxorubicin-Induced Cardiotoxicity Based on Network Pharmacology and Experimental Evaluation

TP53 co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside KRAS, STK11 and KEAP1 mutations