Krasg12d | List of Frontiers open access articles

Original Research

Published on 28 Jan 2026

Antitumor effects of LPM5140276 and its potential combination with SHP2 inhibition in KRASG12D-mutant cancer

in Pharmacology of Anti-Cancer Drugs

Zhengping Hu
Fangxia Zou
Fengjuan Zhao
Pengfei Yu
Haibo Zhu
Liting Yu
Wenyan Wang
Liang Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554356

734 views

Original Research

Published on 19 Aug 2022

Aberrant activation of KRAS in mouse theca-interstitial cells results in female infertility

in Reproduction

Penghao Sun
Hongliang Wang
Lingyun Liu
Kaimin Guo
Xian Li
Yin Cao
Chemyong Ko
Zi-Jian Lan
Zhenmin Lei

Frontiers in Physiology

doi 10.3389/fphys.2022.991719

3,719 views
2 citations

Original Research

Published on 23 Jun 2021

Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks

in Epigenomics and Epigenetics

Guillermo Urrutia
Thiago Milech de Assuncao
Angela J. Mathison
Ann Salmonson
Romica Kerketta
Atefeh Zeighami
Timothy J. Stodola
Volkan Adsay
Burcin Pehlivanoglu
Michael B. Dwinell

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.681153

8,283 views
10 citations

Original Research

Published on 22 Dec 2022

Discovery of potent and noncovalent KRASG12D inhibitors: Structure-based virtual screening and biological evaluation

in Experimental Pharmacology and Drug Discovery

Yuting Wang
Hai Zhang
Jindong Li
Miao-Miao Niu
Yang Zhou
Yuanqian Qu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1094887

7,468 views
10 citations

Review

Published on 26 Oct 2016

Autophagy Induced during Pancreatitis Promotes KRAS-Dependent Transformation in the Pancreas

in Molecular and Cellular Oncology

Juan L. Iovanna

Frontiers in Oncology

doi 10.3389/fonc.2016.00226

5,469 views
9 citations

Brief Research Report

Published on 06 Jan 2026

Glycolytic reprogramming of resident alveolar macrophages contributes to reduced SOCS3 secretion in non-small cell lung cancer

in Cancer Immunity and Immunotherapy

Jennifer M. Speth
Mikel D. Haggadone
Marc Peters-Golden

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708467

1,055 views

Mini Review

Published on 22 May 2024

Structural perspectives on recent breakthrough efforts toward direct drugging of RAS and acquired resistance

in Cancer Molecular Targets and Therapeutics

Jameela Lokhandwala
Tracess B. Smalley
Timothy H. Tran

Frontiers in Oncology

doi 10.3389/fonc.2024.1394702

9,328 views
15 citations

Original Research

Published on 13 May 2022

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

in Molecular and Cellular Pathology

Li Ding
Kaely Roeck
Cheng Zhang
Brooke Zidek
Esther Rodman
Yasmin Hernandez-Barco
Jin-San Zhang
William Bamlet
Ann Oberg
Lizhi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.853003

4,118 views
5 citations

Brief Research Report

Published on 25 Feb 2026

Tumor microenvironment-activated ferritin nanovector enables enhanced tumor delivery of KRASG12C inhibitors and degraders

in Signaling

Annalisa Pia Abbinantefina
Claudia Tito
Silvia Masciarelli
Giada Tisci
Siria Sortoluzzi
Pierpaolo Ceci
Elisabetta Falvo
Cécile Exertier
Francesca Troilo
Vincenzo Petrozza

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1725088

265 views

Original Research

Published on 24 Mar 2022

RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells

in Cancer Molecular Targets and Therapeutics

Mahmut Mijit
Randall Wireman
Lee Armstrong
Silpa Gampala
Zonera Hassan
Christian Schneeweis
Guenter Schneider
Chi Zhang
Melissa L. Fishel
Mark R. Kelley

Frontiers in Oncology

doi 10.3389/fonc.2022.826617

6,851 views
13 citations

Original Research

Published on 07 Jun 2018

Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules

in Comparative Immunology

Nana H. Overgaard
Daniel R. Principe
Kyle M. Schachtschneider
Jeanne Toft Jakobsen
Laurie A. Rund
Paul J. Grippo
Lawrence B. Schook
Gregers Jungersen

Frontiers in Immunology

doi 10.3389/fimmu.2018.01301

8,075 views
25 citations

Original Research

Published on 29 Apr 2021

Transcriptional Profiling of Porcine HCC Xenografts Provides Insights Into Tumor Cell Microenvironment Signaling

in Systems Biology Archive

Shovik S. Patel
Amitha Sandur
Mohammed El-Kebir
Ron C. Gaba
Lawrence B. Schook
Kyle M. Schachtschneider

Frontiers in Genetics

doi 10.3389/fgene.2021.657330

4,938 views
5 citations

Articles

Antitumor effects of LPM5140276 and its potential combination with SHP2 inhibition in KRASG12D-mutant cancer

Aberrant activation of KRAS in mouse theca-interstitial cells results in female infertility

Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks

Discovery of potent and noncovalent KRASG12D inhibitors: Structure-based virtual screening and biological evaluation

Autophagy Induced during Pancreatitis Promotes KRAS-Dependent Transformation in the Pancreas

Glycolytic reprogramming of resident alveolar macrophages contributes to reduced SOCS3 secretion in non-small cell lung cancer

Structural perspectives on recent breakthrough efforts toward direct drugging of RAS and acquired resistance

Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN

Tumor microenvironment-activated ferritin nanovector enables enhanced tumor delivery of KRASG12C inhibitors and degraders

RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells

Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules

Transcriptional Profiling of Porcine HCC Xenografts Provides Insights Into Tumor Cell Microenvironment Signaling