Large Scale Optimization | List of Frontiers open access articles

Original Research

Published on 14 May 2026

Gut microbiota-associated immunomodulation contributes to the protective effects of fluvastatin against endometriosis in a mouse model, accompanied by increased Akkermansia muciniphila abundance

in Microorganisms in Vertebrate Digestive Systems

Huilin Yang
Shuai Liu
Xia Chen
Chenxi Yin
Longxia Xiao
Wenmin Xu
Shuaijun Lv
Li Xie
Chunhua Yin

Frontiers in Microbiology

doi 10.3389/fmicb.2026.1762444

193 views

Original Research

Published on 14 May 2026

Hurricane impacts on oyster reef habitat in a large, wind-driven estuary

in Marine Ecosystem Ecology

Daniel J. Bowling
Olivia N. Caretti
David B. Eggleston

Frontiers in Marine Science

doi 10.3389/fmars.2026.1768666

341 views

Original Research

Published on 14 May 2026

Status and influencing factors of spiritual climate among oncology nurses: a cross-sectional study

in Organizational Psychology

Tianyue Zhang
Chunfeng Dong
Jie Tang
Ping Yu

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1759724

164 views

Original Research

Published on 14 May 2026

Microplastic contamination in remote mountain lakes of the americas: a baseline assessment from Patagonia and Northern California

in Environmental Toxicology

María B. Alfonso
Facundo Scordo
Carina Seitz
Andrés H. Arias
Ana C. Ronda
Gian M. Mavo Manstretta
Sudeep Chandra
Gerardo M. E. Perillo
María C. Piccolo

Frontiers in Toxicology

doi 10.3389/ftox.2026.1851245

358 views

Original Research

Published on 14 May 2026

The impact of physical exercise on depression among college students: the mediating role of core self-evaluation and meaning in life

in Sport Psychology

Xuesong Ji
Sijie Liu
Zhen Ye
Huajian Shi
Fangyuan Chen

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1743318

212 views

Original Research

Published on 14 May 2026

Potential for biohydrogen production in the United States: a granular assessment

in Hydrogen Storage and Production

Siddhartha Narra
Anurag Mandalika
Timothy Fitzgerald
Brian Snyder

Frontiers in Energy Research

doi 10.3389/fenrg.2026.1773794

330 views

Systematic Review

Published on 14 May 2026

First-line immunotherapy for advanced hepatocellular carcinoma: a network meta-analysis of randomized trials with overall and HBV/HCV-stratified efficacy and safety

in Cancer Immunity and Immunotherapy

Wei Chen
Boyan Chen
Chunbin Hu
Qiance Wei
Lili Zhang
Wenwen Fu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1693251

181 views

Review

Published on 14 May 2026

Adoptive cell therapies in solid tumors: current clinical landscape, challenges, and future directions

in Cancer Immunity and Immunotherapy

Joe Rizkallah
Bahaa El Deen Wehbeh
Waseem Wassouf
Elio Salameh
Adnan Joumaa
Francois Jose Haddad
Lama Hamade
Nicole Charbel
Ghada M. Bakri
Ali Awada

Frontiers in Immunology

doi 10.3389/fimmu.2026.1800292

341 views

Original Research

Published on 14 May 2026

Spiritual leadership, flourishing, organizational commitment, and productivity of nurses in healthcare crisis contexts

in Employee Well-being and Health

Malehlwa Constance Madimabe
Freda Van Der Walt
Malefetsane Ephraim Thasi

Frontiers in Organizational Psychology

doi 10.3389/forgp.2026.1795291

296 views

Original Research

Published on 14 May 2026

Reference intervals for plasma IFN-α, TNF-α, IL-12p70, and IFN-γ by flow cytometry in healthy adults from eastern China: a single-center study

in Cytokines and Soluble Mediators in Immunity

Qian Liu
Linru Zhang
Xuanxuan Jiao
Yefu Sun
Fang Yang
Fumeng Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1806685

186 views

Original Research

Published on 14 May 2026

Mesenteric perfusion at rest and during feeding in healthy children

in Systems Interactions and Organ Networks

Kathryn E. Tobert
Kathryn Higdon
Theresa A. Mikhailov
John P. Scott
Wendi Redfern
George M. Hoffman

Frontiers in Network Physiology

doi 10.3389/fnetp.2026.1739687

297 views

Original Research

Published on 14 May 2026

A novel glycolipid composite index predicting cardiovascular disease in Chinese adults with abnormal glucose metabolism: a nationwide cohort study

in Cardiovascular Epidemiology and Prevention

Dan-dan Peng
Ping Zhu
Ji-chen Xie
Wei Yong
Kai Ye
Jun-jie Gao
Zhao-xia Shuai

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1791890

323 views

Original Research

Published on 14 May 2026

Associations of changes in waist-to-height ratio with all-cause mortality among Chinese older adults: a national cohort study

in Nutritional Epidemiology

Juanxia Miao
Xue Wang
Kun Huang
Yiwen Wang
Shuang Zang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1839686

249 views

Original Research

Published on 14 May 2026

Profiling dysregulated circRNA expression in diabetic retinopathy: elucidating putative mediators via a streptozotocin-induced mouse model

in Diabetes: Molecular Mechanisms

Conghui Zhang
Le Feng
Qian Li
Hongping Cui

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1804009

300 views

Original Research

Published on 14 May 2026

Evaluating the diagnostic and prognostic utility of serum DLL1 in acute-on-chronic liver failure patients with bacterial infections

in Hepatobiliary Diseases

Juanjun Huang
Zhi Wang
Wei Zhu
Jian Chen

Frontiers in Medicine

doi 10.3389/fmed.2026.1735014

230 views

Original Research

Published on 14 May 2026

From desert margins to irrigated oases: spatiotemporal dynamics and driving mechanisms of integrated ecological risk in an arid river basin using coupled RSEI-LERI and XGBoost-SHAP frameworks (2001–2025)

in Conservation and Restoration Ecology

Yuanqing Cao
Huihui Wang
Xuan Chen
Zhanfeng Shen
Haoyu Wang
Maolin Li

Frontiers in Ecology and Evolution

doi 10.3389/fevo.2026.1835673

212 views

Articles

Gut microbiota-associated immunomodulation contributes to the protective effects of fluvastatin against endometriosis in a mouse model, accompanied by increased Akkermansia muciniphila abundance

Hurricane impacts on oyster reef habitat in a large, wind-driven estuary

Status and influencing factors of spiritual climate among oncology nurses: a cross-sectional study

Microplastic contamination in remote mountain lakes of the americas: a baseline assessment from Patagonia and Northern California

The impact of physical exercise on depression among college students: the mediating role of core self-evaluation and meaning in life

Potential for biohydrogen production in the United States: a granular assessment

First-line immunotherapy for advanced hepatocellular carcinoma: a network meta-analysis of randomized trials with overall and HBV/HCV-stratified efficacy and safety

Adoptive cell therapies in solid tumors: current clinical landscape, challenges, and future directions

Spiritual leadership, flourishing, organizational commitment, and productivity of nurses in healthcare crisis contexts

Reference intervals for plasma IFN-α, TNF-α, IL-12p70, and IFN-γ by flow cytometry in healthy adults from eastern China: a single-center study

Mesenteric perfusion at rest and during feeding in healthy children

A novel glycolipid composite index predicting cardiovascular disease in Chinese adults with abnormal glucose metabolism: a nationwide cohort study

Associations of changes in waist-to-height ratio with all-cause mortality among Chinese older adults: a national cohort study

Profiling dysregulated circRNA expression in diabetic retinopathy: elucidating putative mediators via a streptozotocin-induced mouse model

Evaluating the diagnostic and prognostic utility of serum DLL1 in acute-on-chronic liver failure patients with bacterial infections

From desert margins to irrigated oases: spatiotemporal dynamics and driving mechanisms of integrated ecological risk in an arid river basin using coupled RSEI-LERI and XGBoost-SHAP frameworks (2001–2025)