Lead Discovery | List of Frontiers open access articles

Original Research

Published on 10 Feb 2026

Effect of Xiaonang Yusi decoction (消囊育嗣汤) on IVF outcomes in patients with phlegm-dampness type PCOS: a prospective cohort study with supporting metabolomics, network pharmacology, and molecular docking analysis

in Obstetrics and Gynecology

Xin Hu
Qingmei Jin
Hengbing Li
Jingyan Song
Haining Yuan
Ying Xu
Kailiang Ai
Zizhen Guo
Zhenni Mu
Zhengao Sun

Frontiers in Medicine

doi 10.3389/fmed.2026.1680327

226 views

Original Research

Published on 10 Feb 2026

Exotic matter and MOND as special cases of a more general solution in pure general relativity

in Extragalactic Astronomy

Stephane Le Corre

Frontiers in Astronomy and Space Sciences

doi 10.3389/fspas.2025.1664364

740 views

Original Research

Published on 10 Feb 2026

A mammalian, glutaminase-free asparaginase enhances venetoclax activity in preclinical AML models with chromosome 7 deletion

in Hematologic Malignancies

Dhabya Majid
Zhe Wang
Amanda M. Schalk
Bin Yuan
Qi Zhang Tatarata
Jessica L. Root
Araceli Isabella Garza
Mhd Yousuf Yassouf
Basant T. Gamal
Sammy Feri-Borgogno

Frontiers in Oncology

doi 10.3389/fonc.2025.1606239

455 views

Original Research

Published on 10 Feb 2026

ProMMF_Kron: a multimodal deep learning model for immunotherapy response prediction in stomach adenocarcinoma

in Cancer Immunity and Immunotherapy

Chenchen Wang
Weikun Liu
Dongmei Ai
Xiuqin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1602846

226 views

Original Research

Published on 10 Feb 2026

Optimizing cloud data center performance with demand-responsive load-balancing scheme

in Networks and Communications

Mudasiru Hammed
Jumoke Soyemi

Frontiers in Computer Science

doi 10.3389/fcomp.2025.1500156

311 views

Original Research

Published on 10 Feb 2026

What drives people to play pickleball? A mixed-methods study using SEM and fsQCA

in Sport Psychology

Wenzhe Huang
Duxiang Xiao
Bojin Cheng

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1740931

204 views

Original Research

Published on 10 Feb 2026

A retrospective cohort study on the impact of finerenone on the hepatic fibrosis indicator FIB-4

in Clinical Diabetes

Bo An
Fang Chen
Wencheng An
Zhijun Cui
Lin Jiang
Shujing Zhou
Mingda Song
Wei Huang
Huixian Yan

Frontiers in Endocrinology

doi 10.3389/fendo.2026.1745102

310 views

Original Research

Published on 10 Feb 2026

Effects of affective vs. instructional teacher scaffolding on preschoolers’ emotional engagement and social attention in picturebook reading

in Educational Psychology

Sifan Wu
Tao Song

Frontiers in Psychology

doi 10.3389/fpsyg.2026.1743106

236 views

Original Research

Published on 10 Feb 2026

Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice

in Experimental Pharmacology and Drug Discovery

Shan Luo
Yake Lan
Ruoqi Zhang
Zhongqiu Luan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1737091

373 views

Review

Published on 10 Feb 2026

Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging

in Cellular and Molecular Mechanisms of Brain-aging

Fan Guo
Jiapei Chi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1737001

1,125 views

Original Research

Published on 10 Feb 2026

Current practices in robotic surgery for distal ureter in children: results from an EAU robotic urology section (ERUS) survey

in Pediatric Urology

Girolamo Mattioli
Luca Genova Gaia
Marcello Carlucci
Andrea Minervini
Furkan Sendogan
Mesrur Selcuk Silay
Hubert John
Venusia Fiorenza

Frontiers in Pediatrics

doi 10.3389/fped.2026.1729840

259 views

Original Research

Published on 10 Feb 2026

“We are responsible for deciding how we, as farmers, influence political decisions”: adaptation practices to droughts by small-scale farmers in a globally important South American Archipelago

in Land, Livelihoods and Food Security

Santiago Kaulen
Camilo Oyarzo
Carla Marchant
Paulina Rodríguez-Díaz
Julián Caviedes
Germán Schlicht
José Tomás Ibarra

Frontiers in Sustainable Food Systems

doi 10.3389/fsufs.2026.1729843

268 views

Original Research

Published on 10 Feb 2026

Supportless overhanging structures via piezoelectric droplet-based material extrusion

in Digital Manufacturing

Francesco Buonamici
Rocco Furferi
Monica Carfagni
David Tapinassi
Yary Volpe

Frontiers in Mechanical Engineering

doi 10.3389/fmech.2026.1717183

147 views

Original Research

Published on 10 Feb 2026

Triglyceride-glucose index at ICU admission predicts hospital mortality in patients with acute coronary syndrome concomitant sepsis: a Bayesian network analysis of retrospective multicenter cohort study

in Nutrition and Metabolism

Yan Liu
Yingyi Luan
Lei Wang
Yinuo Zhu
Guoying Zheng
Jinxia Zhang
Zhifeng Liu
Yongming Yao
Ming Wu

Frontiers in Nutrition

doi 10.3389/fnut.2026.1716973

288 views

Original Research

Published on 10 Feb 2026

Superior simultaneous immobilization of cadmium and arsenic by ferrihydrite-modified biochar: performance and mechanisms

in Toxicology, Pollution and the Environment

Xiaowen Teng
Weizhong Yang
Hanbo Chen
Xuqiao Wu
Jianing Tang
Xiaohui Yang
Zhenyu Liu
Dan Liu
Weijie Xu

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1717178

485 views

Brief Research Report

Published on 10 Feb 2026

Premature release of action sequences in adolescent male rats

in Motivation and Reward

Micaela Betsabé Marini
Mariano Andrés Belluscio
Mario Gustavo Murer
María Cecilia Martínez

Frontiers in Behavioral Neuroscience

doi 10.3389/fnbeh.2026.1716850

280 views

Articles

Effect of Xiaonang Yusi decoction (消囊育嗣汤) on IVF outcomes in patients with phlegm-dampness type PCOS: a prospective cohort study with supporting metabolomics, network pharmacology, and molecular docking analysis

Exotic matter and MOND as special cases of a more general solution in pure general relativity

A mammalian, glutaminase-free asparaginase enhances venetoclax activity in preclinical AML models with chromosome 7 deletion

ProMMF_Kron: a multimodal deep learning model for immunotherapy response prediction in stomach adenocarcinoma

Optimizing cloud data center performance with demand-responsive load-balancing scheme

What drives people to play pickleball? A mixed-methods study using SEM and fsQCA

A retrospective cohort study on the impact of finerenone on the hepatic fibrosis indicator FIB-4

Effects of affective vs. instructional teacher scaffolding on preschoolers’ emotional engagement and social attention in picturebook reading

Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice

Astaxanthin as a neuroprotective modulator of synaptic plasticity, learning, and memory: mechanistic insights and therapeutic perspectives in neurodegenerative aging

Current practices in robotic surgery for distal ureter in children: results from an EAU robotic urology section (ERUS) survey

“We are responsible for deciding how we, as farmers, influence political decisions”: adaptation practices to droughts by small-scale farmers in a globally important South American Archipelago

Supportless overhanging structures via piezoelectric droplet-based material extrusion

Triglyceride-glucose index at ICU admission predicts hospital mortality in patients with acute coronary syndrome concomitant sepsis: a Bayesian network analysis of retrospective multicenter cohort study

Superior simultaneous immobilization of cadmium and arsenic by ferrihydrite-modified biochar: performance and mechanisms

Premature release of action sequences in adolescent male rats