Lead Discovery | List of Frontiers open access articles

Hypothesis and Theory

Published on 19 Feb 2026

Mechanical polarity as a driver of bone regeneration: a multiscale framework linking tension, mechanotransduction and cortical apposition

in Biomechanics

Anna Ewa Kuc
Jacek Kotuła
Natalia Kuc
Joanna Lis
Beata Kawala
Michał Sarul
Magdalena Sulewska

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1771800

Editorial

Published on 19 Feb 2026

Editorial: Advances in DYRK1A syndrome: underlying mechanisms, disease models, and novel therapeutic approaches

in Neurodevelopment

Oliver K. Glass
Amelie Piton
Anna Pfalzer

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1803346

196 views

Original Research

Published on 19 Feb 2026

Biodiversity and structural analysis of forests at the altitudinal boundary between dry and montane forests: response of tree diversity to altitudinal variation in the northeastern Peruvian Andes

in Tropical Forests

Elver Coronel-Castro
Elí Pariente-Mondragón
Rosalynn Y. Rivera
Junior Chacón
Aldair Delgado
Manuel Oliva-Cruz
Angel Fernando Huamán-Pilco

Frontiers in Forests and Global Change

doi 10.3389/ffgc.2026.1765957

153 views

Systematic Review

Published on 19 Feb 2026

Barriers to accessing healthcare for people with disabilities:a systematic review

in Public Health Policy

M. Chimienti
G. Morlino
D. Ndreca
K. Stefanidhi
O. Zerellari
R. Shkreli
S. Gjergji
F. Leonforte
V. Nicosia
A. Mistretta

Frontiers in Public Health

doi 10.3389/fpubh.2026.1765145

253 views

Original Research

Published on 19 Feb 2026

The hidden link between iron deficiency and celiac disease: a clinical perspective

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Laura Tarancon-Diez
Guillermo Perez-Cabeza
Pilar Sanchez-Mingo
Pedro Crespo-de la Rosa
Rita-Maria Garcia
Marianela Iriarte-Gahete
Yolanda M. Pacheco
Manuel Leal

Frontiers in Immunology

doi 10.3389/fimmu.2026.1744005

382 views

Case Report

Published on 19 Feb 2026

Case Report: Parachute tricuspid valve in association with cyanotic congenital heart disease and juxtaposed atrial appendages in a 1-year-old boy—a rare anatomical association

in Pediatric Cardiology

Devender Sangwan
Ashutosh Marwah
Vaishali Jain

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1683429

158 views

Original Research

Published on 19 Feb 2026

Integrating pleural PD-1+CD8+ T cell as a complement variable into LENT score to assess patients with lung adenocarcinoma complicated with MPE

in T Cell Biology

Weizhen Jiang
Leilei Lv
Yaoxin Zhang
Qiuxia Qu
Cheng Chen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1630590

122 views

Brief Research Report

Published on 19 Feb 2026

The overlooked burden: anti-seizure medications, laxatives, and antipsychotics prescribed in primary care for people with intellectual disability

in Intellectual Disabilities

Richard Laugharne
Ian Wilson
Mike Wilcock
Rohit Shankar

Frontiers in Psychiatry

doi 10.3389/fpsyt.2026.1714524

139 views

Original Research

Published on 19 Feb 2026

Experimental workshops at the Climate HubLAB: a case study on learning spaces for experiential learning through pedagogy and technology

in Higher Education

Mariya Stefanova Stoyanova Bond
Leif Martin Hokstad
Luca Finocchiaro

Frontiers in Education

doi 10.3389/feduc.2026.1719730

107 views

Review

Published on 19 Feb 2026

Exosomal non-coding RNAs in autoimmune diseases: molecular mechanisms and potential applications

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yunbing Wu
Xia Li
Yue Jin
Fei Mao
Lu Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1753611

108 views

Systematic Review

Published on 19 Feb 2026

Risk factors for depression in systemic lupus erythematosus: a systematic review and meta-analysis

in Rheumatology

Linling Zhu
Jinju Chen
Yaping Sha
Huiren Zhuang
Chunhua Ye

Frontiers in Medicine

doi 10.3389/fmed.2026.1751870

107 views

Original Research

Published on 19 Feb 2026

Driving factors of agricultural artificial intelligence adoption intention: an empirical study in Shandong province based on innovation characteristics, technology commitment, and individual heterogeneity

in AI in Food, Agriculture and Water

Kai Cao
Ping Wang
Siyu Kong
Chunzhen Zhang

Frontiers in Artificial Intelligence

doi 10.3389/frai.2026.1630717

196 views

Original Research

Published on 19 Feb 2026

Institutional analysis of agroforestry in the Western Highlands of Cameroon: processes and outcomes

in Natural Resources

Alei Christa Nihngwo
Nyong Princely Awazi
Jude Ndzifon Kimengsi

Frontiers in Sustainable Resource Management

doi 10.3389/fsrma.2026.1732587

139 views

Original Research

Published on 19 Feb 2026

Trends in the prevalence and burden of mental disorders among adolescents and young adults, 1990–2021

in Children and Health

Huiyuan Pang
Yixuan Lu
Xianxian Yuan
Ruihua Yang
Yujie Zhang
Xin Yan
Lirui Zhang
Junhua Huang
Wei Zheng
Guanghui Li

Frontiers in Public Health

doi 10.3389/fpubh.2026.1767326

101 views

Review

Published on 19 Feb 2026

Can artificial intelligence in orthopantomography advance dental diagnostics through automated image analysis?

in Artificial Intelligence in Radiology

Dan Adrian Lutescu
Claudiu Constantin Manole
Ana Maria Cristina Țâncu
Radu Ilinca
Reinhard Chun Wang Chau
Szabolcs Felszeghy
Andreea Cristiana Didilescu

Frontiers in Radiology

doi 10.3389/fradi.2026.1701356

257 views

Original Research

Published on 19 Feb 2026

Is flipped classroom really superior?—Questioning the flip in K-12 teaching

in Digital Education

Patrick Wiesner
Stefan Krauss
Nathalie Stegmüller
Karin Binder

Frontiers in Education

doi 10.3389/feduc.2026.1741733

288 views

Articles

Mechanical polarity as a driver of bone regeneration: a multiscale framework linking tension, mechanotransduction and cortical apposition

Editorial: Advances in DYRK1A syndrome: underlying mechanisms, disease models, and novel therapeutic approaches

Biodiversity and structural analysis of forests at the altitudinal boundary between dry and montane forests: response of tree diversity to altitudinal variation in the northeastern Peruvian Andes

Barriers to accessing healthcare for people with disabilities:a systematic review

The hidden link between iron deficiency and celiac disease: a clinical perspective

Case Report: Parachute tricuspid valve in association with cyanotic congenital heart disease and juxtaposed atrial appendages in a 1-year-old boy—a rare anatomical association

Integrating pleural PD-1+CD8+ T cell as a complement variable into LENT score to assess patients with lung adenocarcinoma complicated with MPE

The overlooked burden: anti-seizure medications, laxatives, and antipsychotics prescribed in primary care for people with intellectual disability

Experimental workshops at the Climate HubLAB: a case study on learning spaces for experiential learning through pedagogy and technology

Exosomal non-coding RNAs in autoimmune diseases: molecular mechanisms and potential applications

Risk factors for depression in systemic lupus erythematosus: a systematic review and meta-analysis

Driving factors of agricultural artificial intelligence adoption intention: an empirical study in Shandong province based on innovation characteristics, technology commitment, and individual heterogeneity

Institutional analysis of agroforestry in the Western Highlands of Cameroon: processes and outcomes

Trends in the prevalence and burden of mental disorders among adolescents and young adults, 1990–2021

Can artificial intelligence in orthopantomography advance dental diagnostics through automated image analysis?

Is flipped classroom really superior?—Questioning the flip in K-12 teaching