Articles

Multi-scale models of whole cells: progress and challenges

in Morphogenesis and Patterning

• Konstantia Georgouli
• Jae-Seung Yeom
• Robert C. Blake
• Ali Navid

Navigating Multi-Scale Cancer Systems Biology Towards Model-Driven Clinical Oncology and Its Applications in Personalized Therapeutics

in Pharmacology of Anti-Cancer Drugs

• Mahnoor Naseer Gondal
• Safee Ullah Chaudhary

Bridging Hierarchies in Multi-Scale Models of Neural Systems: Look-Up Tables Enable Computationally Efficient Simulations of Non-linear Synaptic Dynamics

• Duy-Tan J. Pham
• Gene J. Yu
• Jean-Marie C. Bouteiller
• Theodore W. Berger

Multi-Scale Computational Models for Electrical Brain Stimulation

in Brain Imaging and Stimulation

• Hyeon Seo
• Sung C. Jun

Multi-scale mechanobiological model for skeletal muscle hypertrophy

in Striated Muscle Physiology

• Yesid Villota-Narvaez
• Diego A. Garzón-Alvarado
• Oliver Röhrle
• Angelica M. Ramírez-Martínez

Optimizing Dosage-Specific Treatments in a Multi-Scale Model of a Tumor Growth

in Biological Modeling and Simulation

• Miguel Ponce-de-Leon
• Arnau Montagud
• Charilaos Akasiadis
• Janina Schreiber
• Thaleia Ntiniakou
• Alfonso Valencia

Viruses in multi-scale ocean models: challenges and opportunities

in Aquatic Microbiology

• David Talmy
• Cristina Howard-Varona
• Damien Eveillard
• Markus Covert
• Matthew B. Sullivan

Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications

in Evolutionary Developmental Biology

• Karl J. Niklas
• Sarah E. Bondos
• A. Keith Dunker
• Stuart A. Newman

Crops In Silico: Generating Virtual Crops Using an Integrative and Multi-scale Modeling Platform

in Plant Systems and Synthetic Biology

• Amy Marshall-Colon
• Stephen P. Long
• Douglas K. Allen
• Gabrielle Allen
• Daniel A. Beard
• Bedrich Benes
• Susanne von Caemmerer
• A. J. Christensen
• Donna J. Cox
• John C. Hart

A Comparison Between Single- and Multi-Scale Approaches for Classification of Histopathology Images

in Digital Public Health

• Marina D'Amato
• Przemysław Szostak
• Benjamin Torben-Nielsen

Toward a Multi-Scale Computational Model of Arterial Adaptation in Hypertension: Verification of a Multi-Cell Agent Based Model

in Computational Physiology and Medicine

• Bryan C. Thorne
• Heather N. Hayenga
• Jay D. Humphrey
• Shayn M. Peirce

Three-Dimensional Quantification of Collagen Microstructure During Tensile Mechanical Loading of Skin

in Biomechanics

• Alan E. Woessner
• Jake D. Jones
• Nathan J. Witt
• Edward A. Sander
• Kyle P. Quinn

A Liquid State Perspective on Dynamics of Chromatin Compartments

in Biophysics

• Rabia Laghmach
• Michele Di Pierro
• Davit Potoyan

How Computation Is Helping Unravel the Dynamics of Morphogenesis

in Interdisciplinary Physics

• David Pastor-Escuredo
• Juan C. del Álamo

Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status

in Cancer Immunity and Immunotherapy

• Carlijn M. Lems
• Gerhard A. Burger
• Joost B. Beltman

Enabling Detailed, Biophysics-Based Skeletal Muscle Models on HPC Systems

in Computational Physiology and Medicine

• Chris P. Bradley
• Nehzat Emamy
• Thomas Ertl
• Dominik Göddeke
• Andreas Hessenthaler
• Thomas Klotz
• Aaron Krämer
• Michael Krone
• Benjamin Maier
• Miriam Mehl