Paratope | List of Frontiers open access articles

Original Research

Published on 24 Sep 2021

Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics Approach

in Vaccines and Molecular Therapeutics

Veerbhan Kesarwani
Rupal Gupta
Ramesh Raju Vetukuri
Sandeep Kumar Kushwaha
Sonu Gandhi

Frontiers in Immunology

doi 10.3389/fimmu.2021.725240

9,684 views
15 citations

Original Research

Published on 02 Mar 2021

Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution

in B Cell Biology

Monica L. Fernández-Quintero
Katharina B. Kroell
Florian Hofer
Jakob R. Riccabona
Klaus R. Liedl

Frontiers in Immunology

doi 10.3389/fimmu.2021.630034

5,932 views
30 citations

Review

Published on 21 Nov 2022

Research progress on unique paratope structure, antigen binding modes, and systematic mutagenesis strategies of single-domain antibodies

in Microbial Immunology

Chang Liu
Hong Lin
Limin Cao
Kaiqiang Wang
Jianxin Sui

Frontiers in Immunology

doi 10.3389/fimmu.2022.1059771

7,263 views
24 citations

Original Research

Published on 10 Aug 2021

Germline-Dependent Antibody Paratope States and Pairing Specific VH-VL Interface Dynamics

in B Cell Biology

Monica L. Fernández-Quintero
Katharina B. Kroell
Lisa M. Bacher
Johannes R. Loeffler
Patrick K. Quoika
Guy Georges
Alexander Bujotzek
Hubert Kettenberger
Klaus R. Liedl

Frontiers in Immunology

doi 10.3389/fimmu.2021.675655

8,559 views
32 citations

Original Research

Published on 02 Mar 2018

Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification

in B Cell Biology

Jeliazko R. Jeliazkov
Adnan Sljoka
Daisuke Kuroda
Nobuyuki Tsuchimura
Naoki Katoh
Kouhei Tsumoto
Jeffrey J. Gray

Frontiers in Immunology

doi 10.3389/fimmu.2018.00413

15,952 views
57 citations

Original Research

Accepted on 31 Jan 2026

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

in Comparative Immunology

Jun Jet Hen
Ariel Isaacs
Benjamin Liang
Tony Schountz
Keith Chappell
Paul R. Young
Naphak Modhiran
Daniel Watterson

Frontiers in Immunology

169 views

Original Research

Published on 24 Aug 2022

Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab

in Vaccines and Molecular Therapeutics

Clara Luzia Magnus
Andreas Hiergeist
Philipp Schuster
Anette Rohrhofer
Jan Medenbach
André Gessner
David Peterhoff
Barbara Schmidt

Frontiers in Immunology

doi 10.3389/fimmu.2022.966236

5,940 views
25 citations

Original Research

Published on 11 Aug 2020

Diagnostic and Epitope Mapping Potential of Single-Chain Antibody Fragments Against Foot-and-Mouth Disease Virus Serotypes A, SAT1, and SAT3

in Veterinary Infectious Diseases

Melanie Chitray
Pamela Anne Opperman
Lia Rotherham
Jeanni Fehrsen
Wouter van Wyngaardt
Janine Frischmuth
Elizabeth Rieder
Francois Frederick Maree

Frontiers in Veterinary Science

doi 10.3389/fvets.2020.00475

5,566 views
8 citations

Original Research

Published on 26 Feb 2019

Antibody Specific B-Cell Epitope Predictions: Leveraging Information From Antibody-Antigen Protein Complexes

in B Cell Biology

Martin Closter Jespersen
Swapnil Mahajan
Bjoern Peters
Morten Nielsen
Paolo Marcatili

Frontiers in Immunology

doi 10.3389/fimmu.2019.00298

42,387 views
152 citations

Original Research

Published on 20 May 2022

Shape Complementarity Optimization of Antibody–Antigen Interfaces: The Application to SARS-CoV-2 Spike Protein

in Structural Biology

Alfredo De Lauro
Lorenzo Di Rienzo
Mattia Miotto
Pier Paolo Olimpieri
Edoardo Milanetti
Giancarlo Ruocco

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.874296

4,378 views
14 citations

Original Research

Published on 21 Aug 2019

High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias

in Autoimmune and Autoinflammatory Disorders

Donjete Simnica
Simon Schliffke
Christoph Schultheiß
Nicola Bonzanni
Lorenzo F. Fanchi
Nuray Akyüz
Barbara Gösch
Christian Casar
Benjamin Thiele
Janina Schlüter

Frontiers in Immunology

doi 10.3389/fimmu.2019.01897

6,449 views
28 citations

Original Research

Published on 25 Oct 2021

Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent NK Cell-Mediated Cytotoxicity

in Vaccines and Molecular Therapeutics

Lukas Pekar
Daniel Klewinghaus
Paul Arras
Stefania C. Carrara
Julia Harwardt
Simon Krah
Desislava Yanakieva
Lars Toleikis
Vaughn V. Smider
Harald Kolmar

Frontiers in Immunology

doi 10.3389/fimmu.2021.742418

9,102 views
20 citations

Original Research

Published on 12 Nov 2024

Distinct types of VHHs in Alpaca

in B Cell Biology

Xinhao Wang
Lu Zhang
Yao Zhang
Jiaguo Li
Wenfeng Xu
Weimin Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1447212

7,125 views
6 citations

Mini Review

Published on 18 Jun 2018

Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2

in Vaccines and Molecular Therapeutics

Luisa J. Ströh
Kumar Nagarathinam
Thomas Krey

Frontiers in Immunology

doi 10.3389/fimmu.2018.01396

6,305 views
34 citations

Original Research

Published on 28 Mar 2024

Benchmarking antibody clustering methods using sequence, structural, and machine learning similarity measures for antibody discovery applications

in Biological Modeling and Simulation

Dawid Chomicz
Jarosław Kończak
Sonia Wróbel
Tadeusz Satława
Paweł Dudzic
Bartosz Janusz
Mateusz Tarkowski
Piotr Deszyński
Tomasz Gawłowski
Anna Kostyn

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1352508

11,783 views
10 citations

Original Research

Published on 05 Nov 2025

ParaDeep: sequence-based deep learning for residue-level paratope prediction using chain-aware BiLSTM-CNN models

in Protein Bioinformatics

Piyachat Udomwong
Thanathat Pamonsupornwichit
Kanchanok Kodchakorn
Chatchai Tayapiwatana

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1684042

1,729 views
1 citation

Articles

Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics Approach

Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution

Research progress on unique paratope structure, antigen binding modes, and systematic mutagenesis strategies of single-domain antibodies

Germline-Dependent Antibody Paratope States and Pairing Specific VH-VL Interface Dynamics

Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab

Diagnostic and Epitope Mapping Potential of Single-Chain Antibody Fragments Against Foot-and-Mouth Disease Virus Serotypes A, SAT1, and SAT3

Antibody Specific B-Cell Epitope Predictions: Leveraging Information From Antibody-Antigen Protein Complexes

Shape Complementarity Optimization of Antibody–Antigen Interfaces: The Application to SARS-CoV-2 Spike Protein

High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias

Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent NK Cell-Mediated Cytotoxicity

Distinct types of VHHs in Alpaca

Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2

Benchmarking antibody clustering methods using sequence, structural, and machine learning similarity measures for antibody discovery applications

ParaDeep: sequence-based deep learning for residue-level paratope prediction using chain-aware BiLSTM-CNN models