Phase 1 Clinical Trial | List of Frontiers open access articles

Original Research

Published on 29 Jan 2021

A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza®) in Healthy Male Subjects

in Drug Metabolism and Transport

Gang Mai
Lianlian Fan
Mupeng Li
Peiwen Zhang
Chunyan Gan
Qian Huang
Jianzhong Shentu

Frontiers in Pharmacology

doi 10.3389/fphar.2020.610880

9,095 views
7 citations

Clinical Trial

Published on 01 Aug 2023

A phase 1 study of dimdazenil to evaluate the pharmacokinetics, food effect and safety in Chinese healthy subjects

in Neuropharmacology

Fei Wang
Jingjing He
Yanling Zhou
Lijun Ye
Bei Li
Zhiyuan Ma
Chunyan Chen
Ruoxi Zhang
Zhaocun Lin
Jinshan Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1226014

5,671 views
10 citations

Original Research

Published on 27 Feb 2026

A study on the prevalence and influencing factors of the willingness of healthy subjects to participate in clinical trials

in Public Health Education and Promotion

Zhen Shen
Tao Wang
Fang-Fang Liu
Qi-Qiong Ding
Xiao-Qin Liu
Qing Li
Yi-Jun Zhang
Lian-Lian Fan

Frontiers in Public Health

doi 10.3389/fpubh.2026.1735641

223 views

Original Research

Published on 31 Aug 2023

Cost-effectiveness analysis of first-line serplulimab combined with chemotherapy for extensive-stage small cell lung cancer

in Health Economics

Xueyan Liang
Xiaoyu Chen
Huijuan Li
Yan Li

Frontiers in Public Health

doi 10.3389/fpubh.2023.1156427

5,827 views
10 citations

Systematic Review

Published on 09 May 2023

Immune checkpoint inhibitors in first-line therapies of metastatic or early triple-negative breast cancer: a systematic review and network meta-analysis

in Cancer Endocrinology

Xueyan Liang
Xiaoyu Chen
Huijuan Li
Yan Li

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1137464

9,369 views
10 citations

Original Research

Published on 22 Nov 2024

Association between various insulin resistance indices and cardiovascular disease in middle-aged and elderly individuals: evidence from two prospectives nationwide cohort surveys

in Cardiovascular Endocrinology

Yan Li
Huijuan Li
Xiaoyu Chen
Xueyan Liang

Frontiers in Endocrinology

doi 10.3389/fendo.2024.1483468

14,255 views
27 citations

Original Research

Published on 30 Apr 2024

Adverse events associated with immune checkpoint inhibitors in non-small cell lung cancer: a safety analysis of clinical trials and FDA pharmacovigilance system

in Cancer Immunity and Immunotherapy

Xueyan Liang
Hewei Xiao
Huijuan Li
Xiaoyu Chen
Yan Li

Frontiers in Immunology

doi 10.3389/fimmu.2024.1396752

11,005 views
9 citations

Systematic Review

Published on 23 Jan 2025

Global bibliometric analysis of traditional Chinese medicine regulating gut microbiota in the treatment of diabetes from 2004 to 2024

in Pharmacoepidemiology

Jieling Liang
Xiaojuan Lin
Xin Liao
Xi Chen
Ying Zhou
Lin Zhang
Yunyun Qin
Haoru Meng
Zhongwen Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533984

3,805 views
2 citations

Review

Published on 27 Jun 2025

A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance

in Ethnopharmacology

Yi Hou
Hong Li
Luochen Zhu
Yue Li
Yue Zeng
Tian Quan
Zhangqiang Xiang
Yue Zhang
Yuan Bian
Yuxun Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537776

6,200 views
7 citations

Original Research

Published on 05 Oct 2022

Dose–response relationship between Chinese visceral adiposity index and type 2 diabetes mellitus among middle-aged and elderly Chinese

in Clinical Diabetes

Liang Pan
Qianqian Xu
Jianmin Liu
Yang Gao
Jun Li
Hongye Peng
Linli Chen
Miyuan Wang
Gang Mai
Shuo Yang

Frontiers in Endocrinology

doi 10.3389/fendo.2022.959860

15,381 views
33 citations

Original Research

Published on 10 Nov 2022

A phase I dose-escalation study of neoantigen-activated haploidentical T cell therapy for the treatment of relapsed or refractory peripheral T-cell lymphoma

in Hematologic Malignancies

Yuan Chen
Hu Zhao
Jing Luo
Youping Liao
Xu Dan
Guoyu Hu
Weiyue Gu

Frontiers in Oncology

doi 10.3389/fonc.2022.944511

2,969 views
6 citations

Original Research

Published on 27 May 2025

Low dose radiotherapy combined with immune checkpoint inhibitors induces ferroptosis in lung cancer via the Nrf2/HO-1/GPX4 axis

in Cancer Immunity and Immunotherapy

Jing Luo
Qiongjie Zhi
Dongxia Li
Yue Xu
Hui Zhu
Lujun Zhao
Guibing Ren
Jian Wang
Ningbo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1558814

4,512 views
3 citations

Clinical Trial

Published on 08 Mar 2019

Booster Vaccination With GVGH Shigella sonnei 1790GAHB GMMA Vaccine Compared to Single Vaccination in Unvaccinated Healthy European Adults: Results From a Phase 1 Clinical Trial

in Vaccines and Molecular Therapeutics

Odile Launay
Augustin G. W. Ndiaye
Valentino Conti
Pierre Loulergue
Antonella Silvia Sciré
Anais Maugard Landre
Pietro Ferruzzi
Naouel Nedjaai
Lena Dorothee Schütte
Joachim Auerbach

Frontiers in Immunology

doi 10.3389/fimmu.2019.00335

9,947 views
61 citations

Original Research

Published on 23 Nov 2022

Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients

in Immunological Tolerance and Regulation

Tatjana Nikolic
Jessica S. Suwandi
Joris Wesselius
Sandra Laban
Antoinette M. Joosten
Petra Sonneveld
Dick Mul
Henk-Jan Aanstoot
John S. Kaddis
Jaap Jan Zwaginga

Frontiers in Immunology

doi 10.3389/fimmu.2022.1054968

8,771 views
43 citations

Review

Published on 04 May 2022

Pharmacomicrobiomics in Western Medicine and Traditional Chinese Medicine in Type 2 Diabetes

in Diabetes: Molecular Mechanisms

Natural Chu
Juliana C. N. Chan
Elaine Chow

Frontiers in Endocrinology

doi 10.3389/fendo.2022.857090

10,511 views
18 citations

Review

Published on 13 Jun 2025

Impacts of amino acid supplementation on renal function and nutritional parameters in patients with renal insufficiency: bibliometric analysis and meta-analysis

in Clinical Nutrition

Xiaoxia Liu
Qiufu Li
Liyuan Zhang
Ying He
Sitao Tan
Xiaoyu Chen
Kefeng Li

Frontiers in Nutrition

doi 10.3389/fnut.2025.1594507

6,477 views
3 citations

Articles

A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza®) in Healthy Male Subjects

A phase 1 study of dimdazenil to evaluate the pharmacokinetics, food effect and safety in Chinese healthy subjects

A study on the prevalence and influencing factors of the willingness of healthy subjects to participate in clinical trials

Cost-effectiveness analysis of first-line serplulimab combined with chemotherapy for extensive-stage small cell lung cancer

Immune checkpoint inhibitors in first-line therapies of metastatic or early triple-negative breast cancer: a systematic review and network meta-analysis

Association between various insulin resistance indices and cardiovascular disease in middle-aged and elderly individuals: evidence from two prospectives nationwide cohort surveys

Adverse events associated with immune checkpoint inhibitors in non-small cell lung cancer: a safety analysis of clinical trials and FDA pharmacovigilance system

Global bibliometric analysis of traditional Chinese medicine regulating gut microbiota in the treatment of diabetes from 2004 to 2024

A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance

Dose–response relationship between Chinese visceral adiposity index and type 2 diabetes mellitus among middle-aged and elderly Chinese

A phase I dose-escalation study of neoantigen-activated haploidentical T cell therapy for the treatment of relapsed or refractory peripheral T-cell lymphoma

Low dose radiotherapy combined with immune checkpoint inhibitors induces ferroptosis in lung cancer via the Nrf2/HO-1/GPX4 axis

Booster Vaccination With GVGH Shigella sonnei 1790GAHB GMMA Vaccine Compared to Single Vaccination in Unvaccinated Healthy European Adults: Results From a Phase 1 Clinical Trial

Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients

Pharmacomicrobiomics in Western Medicine and Traditional Chinese Medicine in Type 2 Diabetes

Impacts of amino acid supplementation on renal function and nutritional parameters in patients with renal insufficiency: bibliometric analysis and meta-analysis