REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1537776
This article is part of the Research TopicMolecular Mechanisms of Platelet Aggregation and Modulation with Herbal Medicine TreatmentView all 5 articles
A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance
Provisionally accepted
- 1The People‘s Hospital of Zhongjiang, Deyang, China
- 2West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
- 3Nantong Tumor Hospital, Nantong, Jiangsu Province, China
- 4Molecular Urooncology Dep. of Urology Klinikum rechts der Isar Technical University of Munich Ismaningerstr, München, Germany
- 5People’s Hospital of Deyang City, Deyang, Sichuan Province, China
- 6AVIC 363 Hospital, Chengdu, Sichuan Province, China
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Platelets are a class of blood cells exfoliated from bone marrow megakaryocytes and important participants in the blood. Aggregation is a prominent part of the platelets involved in the hemostasis process, regulated by multiple signaling pathways. Abnormal platelet aggregation could lead to thrombosis or hemorrhagic disorders, which is closely related to the abnormal expression of receptors inside and outside platelet cells and the mis-transmission of signaling factors. In recent years, natural compounds have been shown to regulate platelet aggregation on different levels, including platelet surface receptors, intracellular signaling factors, and release reaction from platelet secretory granules, due to their structiral characteristics. However, the anti-platelet aggregation mechanism of natural compounds is not comprehensive. Therefore, we have elaborated the main pathways that affect platelet aggregation in terms of the adenosine diphosphate (ADP), the levels of cAMP and cGMP, arachidonic acid (ARA) metabolism pathway, thrombin and collagen pathways in this paper. Particularly, we reviewed various natural compounds such as glycosides, coumarins, alkaloids, and acids that affect platelet aggregation mechanisms through these pathways. This review provides a reference for the application of natural compounds in the structural modification of platelet aggregation as well as in clinical studies.
Keywords: Platelet Aggregation, Platelet Activation, natural compounds, molecular mechanism, clinical trials
Received: 01 Dec 2024; Accepted: 18 Jun 2025.
Copyright: © 2025 Hou, Li, 朱, Li, Zeng, 权, Xiang, Zhang, Bian and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuxun Wei, The People‘s Hospital of Zhongjiang, Deyang, China
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