Polyol Pathway | List of Frontiers open access articles

Original Research

Published on 28 Nov 2025

Adjunctive effects of intermittent fasting and exercise with glibenclamide on diabetic nephropathy in rats: a potential role of the polyol pathway

in Exercise Physiology

Shereen M. Samir
Hend M. Hassan
Rasha Elmowafy
Neven A. Ebrahim
Emad A. Albadawi
Muayad Albadrani
Wejdan Hussain Owaydhah
Mona G. Elhadidy

Frontiers in Physiology

doi 10.3389/fphys.2025.1683271

1,217 views

Original Research

Published on 23 Dec 2024

Inhibition of the polyol pathway by Ducrosia anethifolia extract: plausible implications for diabetic retinopathy treatment

in Ethnopharmacology

Saheem Ahmad
Mohammad Faizan Ali Ahmad
Saif Khan
Sultan Alouffi
Mahvish Khan
Mohd Wajid Ali Khan
Irfan Ahmad Ansari

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1513967

2,329 views
3 citations

Original Research

Published on 07 Sep 2022

Paeonol attenuates retinopathy in streptozotocin-induced diabetes in rats by regulating the oxidative stress and polyol pathway

in Ethnopharmacology

Kaveri M. Adki
Yogesh A. Kulkarni

Frontiers in Pharmacology

doi 10.3389/fphar.2022.891485

3,729 views
9 citations

Review

Published on 17 May 2023

AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration

in Molecular Signalling and Pathways

Reshmee Bhattacharya
Mohammad Rizwan Alam
Mohammad Azhar Kamal
Kyung Jin Seo
Laishram Rajendrakumar Singh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1155175

11,136 views
65 citations

Mini Review

Published on 29 Jun 2021

Fructose Metabolism and Cardiac Metabolic Stress

in Translational Pharmacology

M. Annandale
L. J. Daniels
X. Li
J. P. H. Neale
A. H. L. Chau
H. A. Ambalawanar
S. L. James
P. Koutsifeli
L. M. D. Delbridge
K. M. Mellor

Frontiers in Pharmacology

doi 10.3389/fphar.2021.695486

11,681 views
25 citations

Review

Published on 02 Aug 2012

Aldo-Keto Reductases 1B in Endocrinology and Metabolism

in Experimental Pharmacology and Drug Discovery

Emilie Pastel
Jean-Christophe Pointud
Fanny Volat
Antoine Martinez
Anne-Marie Lefrançois-Martinez

Frontiers in Pharmacology

doi 10.3389/fphar.2012.00148

12,795 views
53 citations

Mini Review

Published on 09 May 2012

Aldose Reductase, Oxidative Stress, and Diabetic Mellitus

in Experimental Pharmacology and Drug Discovery

Waiho Tang
Kathleen Ann Martin
John Hwa

Frontiers in Pharmacology

doi 10.3389/fphar.2012.00087

54,664 views
416 citations

Brief Research Report

Published on 17 Dec 2024

The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence

in Interventions in Aging

Gautham Yepuri
Kushie Kancharla
Riccardo Perfetti
Shoshana Shendelman
Andrew Wasmuth
Ravichandran Ramasamy

Frontiers in Aging

doi 10.3389/fragi.2024.1466281

2,813 views

Review

Published on 27 Jan 2026

Metabolic reprogramming and epigenetic effects due to reducing sugars and glycation products in cancer

in Epigenetics and Metabolism

Savita Bansal
Archana Burman
Taruna Arora
Meenakshi Vachher
Nalini Moza Wali
Bhupender Kumar

Frontiers in Epigenetics and Epigenomics

doi 10.3389/freae.2025.1752493

941 views

Mini Review

Published on 25 Mar 2024

Molecular mechanisms of metabolic dysregulation in diabetic cardiomyopathy

in Cardiovascular Metabolism

Yue Zeng
Yilang Li
Wenyue Jiang
Ning Hou

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1375400

7,479 views
21 citations

Review

Published on 20 Nov 2023

Energy metabolic reprogramming regulates programmed cell death of renal tubular epithelial cells and might serve as a new therapeutic target for acute kidney injury

in Cellular Biochemistry

Limei Zhao
Yajie Hao
Shuqin Tang
Xiutao Han
Rongshan Li
Xiaoshuang Zhou

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2023.1276217

14,755 views
45 citations

Original Research

Published on 10 May 2022

Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway

in Ethnopharmacology

Xiao Yan Liu
Jun Peng
Fei He
Xirali Tursun
Shu Ping Li
Xue Lei Xin
Haji Akber Aisa

Frontiers in Pharmacology

doi 10.3389/fphar.2022.852945

5,546 views
12 citations

Original Research

Published on 03 Mar 2026

Machine learning-based QSAR and molecular modeling of phytocompounds in Barleria buxifolia L. as a potential aldose reductase inhibitor

in Drug Discovery in Bioinformatics

Radul R. Dev
Anjana C. Lalu
Sinana Zarin
Bristow Ben Joseph
Rajesh Raju
Abhithaj Jayanandan
Sangeeth Thekkan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1766339

203 views

Articles

Adjunctive effects of intermittent fasting and exercise with glibenclamide on diabetic nephropathy in rats: a potential role of the polyol pathway

Inhibition of the polyol pathway by Ducrosia anethifolia extract: plausible implications for diabetic retinopathy treatment

Paeonol attenuates retinopathy in streptozotocin-induced diabetes in rats by regulating the oxidative stress and polyol pathway

AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration

Fructose Metabolism and Cardiac Metabolic Stress

Aldo-Keto Reductases 1B in Endocrinology and Metabolism

Aldose Reductase, Oxidative Stress, and Diabetic Mellitus

The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence

Metabolic reprogramming and epigenetic effects due to reducing sugars and glycation products in cancer

Molecular mechanisms of metabolic dysregulation in diabetic cardiomyopathy

Energy metabolic reprogramming regulates programmed cell death of renal tubular epithelial cells and might serve as a new therapeutic target for acute kidney injury

Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway

Machine learning-based QSAR and molecular modeling of phytocompounds in Barleria buxifolia L. as a potential aldose reductase inhibitor