Preformed Fibrils | List of Frontiers open access articles

Review

Published on 22 Jul 2024

Cognitive dysfunction in animal models of human lewy-body dementia

in Alzheimer's Disease and Related Dementias

Caroline Haikal
Graham M. Winston
Michael G. Kaplitt

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1369733

4,834 views
4 citations

Original Research

Published on 28 Oct 2024

Quantitative proteomic analysis using a mouse model of Lewy body dementia induced by α-synuclein preformed fibrils injection

in Cellular and Molecular Mechanisms of Dementia

Fatih Akkentli
In kyu Jang
Yoonseop Choi
Young Min
Jinhee Park
Heejin Jo
Leoni Kim
Aashi Mendpara
Bikram Bains
Dongyoon Yoo

Frontiers in Dementia

doi 10.3389/frdem.2024.1477986

3,641 views
3 citations

Brief Research Report

Published on 15 Jan 2021

Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils

in Cellular and Molecular Mechanisms of Brain-aging

Lien Veys
Jessie Van houcke
Jeroen Aerts
Sophie Van Pottelberge
Michel Mahieu
Audrey Coens
Ronald Melki
Dieder Moechars
Louis De Muynck
Lies De Groef

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.614587

6,049 views
11 citations

Original Research

Published on 26 Jul 2021

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy

in Brain Disease Mechanisms

Lijun Dai
Jiannan Wang
Mingyang He
Min Xiong
Ye Tian
Chaoyang Liu
Zhentao Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.682320

7,264 views
13 citations

Perspective

Published on 04 Sep 2018

Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease

in Neurodegeneration

Megan F. Duffy
Timothy J. Collier
Joseph R. Patterson
Christopher J. Kemp
D. Luke Fischer
Anna C. Stoll
Caryl E. Sortwell

Frontiers in Neuroscience

doi 10.3389/fnins.2018.00621

16,803 views
46 citations

Original Research

Published on 01 Apr 2025

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function

in Neurodegeneration

Sheila M. Fleming
Sophia Scott
Edward J. Hamad
Danielle E. Herman
John G. Holden
Lily Yan
Katrina Linning-Duffy
Christopher J. Kemp
Joseph R. Patterson
Kathryn M. Miller

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1556447

4,216 views
2 citations

Original Research

Published on 31 Aug 2023

Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

in Neurodegeneration

Mohamed Bilal Fares
Omar Alijevic
Stephanie Johne
Cassia Overk
Makoto Hashimoto
Athanasios Kondylis
Anthony Adame
Remi Dulize
Dariusz Peric
Catherine Nury

Frontiers in Neuroscience

doi 10.3389/fnins.2023.1239009

8,828 views
13 citations

Original Research

Published on 16 Mar 2022

An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates

in Brain Imaging Methods

Nakul Ravi Raval
Arafat Nasser
Clara Aabye Madsen
Natalie Beschorner
Emily Eufaula Beaman
Morten Juhl
Szabolcs Lehel
Mikael Palner
Claus Svarer
Pontus Plavén-Sigray

Frontiers in Neuroscience

doi 10.3389/fnins.2022.847074

6,215 views
6 citations

Original Research

Published on 02 Jul 2021

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway

in Neuroinflammation and Neuropathy

Manikandan Samidurai
Bharathi N. Palanisamy
Alejandra Bargues-Carot
Monica Hepker
Naveen Kondru
Sireesha Manne
Gary Zenitsky
Huajun Jin
Vellareddy Anantharam
Anumantha G. Kanthasamy

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.661505

10,408 views
33 citations

Articles

Cognitive dysfunction in animal models of human lewy-body dementia

Quantitative proteomic analysis using a mouse model of Lewy body dementia induced by α-synuclein preformed fibrils injection

Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy

Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function

Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway